Catalog No.
YHE97101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-His125
Predicted molecular weight
16.20 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P53004
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BVR A, BVR, Biliverdin-IX alpha-reductase, BLVRA, Biliverdin reductase A, BLVR
Note
For research use only.
Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population., PMID:19238116
Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations., PMID:19243019
Biliverdin reductase A in the prevention of cellular senescence against oxidative stress., PMID:21099244
A homozygous nonsense mutation (c.214C->A) in the biliverdin reductase alpha gene (BLVRA) results in accumulation of biliverdin during episodes of cholestasis., PMID:21278388
Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis., PMID:23042203
Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells., PMID:25147500
Tat-biliverdin reductase A inhibits inflammatory response by regulation of MAPK and NF-κB pathways in Raw 264.7 cells and edema mouse model., PMID:25239864
17α-Ethinylestradiol can disrupt hemoglobin catabolism in amphibians., PMID:25819740
Epididymosomes: a heterogeneous population of microvesicles with multiple functions in sperm maturation and storage., PMID:26112475
Multiple Genetic Modifiers of Bilirubin Metabolism Involvement in Significant Neonatal Hyperbilirubinemia in Patients of Chinese Descent., PMID:26146841
Evidences of Biological Functions of Biliverdin Reductase A in the Bovine Epididymis., PMID:26395865
Improvement of prognostic performance in severely injured patients by integrated clinico-transcriptomics: a translational approach., PMID:26607226
An Integrated Clinico-transcriptomic Approach Identifies a Central Role of the Heme Degradation Pathway for Septic Complications after Trauma., PMID:26727089
Protective role of biliverdin against bile acid-induced oxidative stress in liver cells., PMID:27387768
Predictive role BLVRA mRNA expression in hepatocellular cancer., PMID:27740521
Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury., PMID:27634590
Genetic Variations in Bilirubin Metabolism Genes and Their Association with Unconjugated Hyperbilirubinemia in Adults., PMID:27943244
Tat-biliverdin reductase A protects INS-1 cells from human islet amyloid polypeptide-induced cytotoxicity by alleviating oxidative stress and ER stress., PMID:28198575
Characteristics of the heme catabolic pathway in mild unconjugated hyperbilirubinemia and their associations with inflammation and disease prevention., PMID:28389660
Bliverdin reductase-A improves neurological function in a germinal matrix hemorrhage rat model., PMID:29203281
Quantitative proteomics reveals that miR-222 inhibits erythroid differentiation by targeting BLVRA and CRKL., PMID:29368338
Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway., PMID:29678206
Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease., PMID:29981845
Identification of a bilirubin receptor that may mediate a component of cholestatic itch., PMID:30657454
Isolation of blue-green eggshell pigmentation-related genes from Putian duck through RNA-seq., PMID:30660177
Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity., PMID:30826467
TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2., PMID:31065010
CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation., PMID:31422074
Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells., PMID:31704097
Heme-Derived Metabolic Signals Dictate Immune Responses., PMID:32082323
Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice., PMID:32131495
[Research advances in neonatal hyperbilirubinemia and gene polymorphisms]., PMID:32204767
Tat-Biliverdin Reductase A Exerts a Protective Role in Oxidative Stress-Induced Hippocampal Neuronal Cell Damage by Regulating the Apoptosis and MAPK Signaling., PMID:32290442
Biliverdin Reductase A (BLVRA) Promotes Colorectal Cancer Cell Progression by Activating the Wnt/β-Catenin Signaling Pathway., PMID:32425592
Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins., PMID:32581154
Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration., PMID:32749068
Research on the Mechanism of Qushi Huayu Decoction in the Intervention of Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Molecular Docking Technology., PMID:33204683
Integrated Analysis of Weighted Gene Coexpression Network Analysis Identifying Six Genes as Novel Biomarkers for Alzheimer's Disease., PMID:34367470
Protective effect of GK2 fused BLVRA protein against oxidative stress-induced dopaminergic neuronal cell damage., PMID:36688733
Dehydrovomifoliol Alleviates Nonalcoholic Fatty Liver Disease via the E2F1/AKT/mTOR Axis: Pharmacophore Modeling and Molecular Docking Study., PMID:36777627
Dynamic Changes of BVRA Protein Levels Occur in Response to Insulin: A Pilot Study in Humans., PMID:37108445
Identification of monocyte-associated biomarkers in systemic lupus erythematosus and their pan-cancer analysis., PMID:37769649
BLVRA exerts its biological effects to induce malignant properties of hepatocellular carcinoma cells via Wnt/β-catenin pathway., PMID:38216836
Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population., PMID:38279097
A Multistep In Silico Approach Identifies Potential Glioblastoma Drug Candidates via Inclusive Molecular Targeting of Glioblastoma Stem Cells., PMID:38619743
UGT1A1 and BLVRA allele and genotype variants in neonatal patients with hyperbilirubinemia in southern China., PMID:39468242
The Role of Renal Medullary Bilirubin and Biliverdin Reductase in Angiotensin II-Dependent Hypertension., PMID:39656666
For research use only. Not for human or drug use.
