Catalog No.
YHE97101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-His125
Predicted molecular weight
16.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P53004
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BVR A, BVR, Biliverdin-IX alpha-reductase, BLVRA, Biliverdin reductase A, BLVR
The Role of Renal Medullary Bilirubin and Biliverdin Reductase in Angiotensin II-Dependent Hypertension., PMID:39656666
UGT1A1 and BLVRA allele and genotype variants in neonatal patients with hyperbilirubinemia in southern China., PMID:39468242
A Multistep In Silico Approach Identifies Potential Glioblastoma Drug Candidates via Inclusive Molecular Targeting of Glioblastoma Stem Cells., PMID:38619743
Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population., PMID:38279097
BLVRA exerts its biological effects to induce malignant properties of hepatocellular carcinoma cells via Wnt/β-catenin pathway., PMID:38216836
Identification of monocyte-associated biomarkers in systemic lupus erythematosus and their pan-cancer analysis., PMID:37769649
Dynamic Changes of BVRA Protein Levels Occur in Response to Insulin: A Pilot Study in Humans., PMID:37108445
Dehydrovomifoliol Alleviates Nonalcoholic Fatty Liver Disease via the E2F1/AKT/mTOR Axis: Pharmacophore Modeling and Molecular Docking Study., PMID:36777627
Protective effect of GK2 fused BLVRA protein against oxidative stress-induced dopaminergic neuronal cell damage., PMID:36688733
Integrated Analysis of Weighted Gene Coexpression Network Analysis Identifying Six Genes as Novel Biomarkers for Alzheimer's Disease., PMID:34367470
Research on the Mechanism of Qushi Huayu Decoction in the Intervention of Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Molecular Docking Technology., PMID:33204683
Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration., PMID:32749068
Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins., PMID:32581154
Biliverdin Reductase A (BLVRA) Promotes Colorectal Cancer Cell Progression by Activating the Wnt/β-Catenin Signaling Pathway., PMID:32425592
Tat-Biliverdin Reductase A Exerts a Protective Role in Oxidative Stress-Induced Hippocampal Neuronal Cell Damage by Regulating the Apoptosis and MAPK Signaling., PMID:32290442
[Research advances in neonatal hyperbilirubinemia and gene polymorphisms]., PMID:32204767
Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice., PMID:32131495
Heme-Derived Metabolic Signals Dictate Immune Responses., PMID:32082323
Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells., PMID:31704097
CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation., PMID:31422074
TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2., PMID:31065010
Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity., PMID:30826467
Isolation of blue-green eggshell pigmentation-related genes from Putian duck through RNA-seq., PMID:30660177
Identification of a bilirubin receptor that may mediate a component of cholestatic itch., PMID:30657454
Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease., PMID:29981845
Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway., PMID:29678206
Quantitative proteomics reveals that miR-222 inhibits erythroid differentiation by targeting BLVRA and CRKL., PMID:29368338
Bliverdin reductase-A improves neurological function in a germinal matrix hemorrhage rat model., PMID:29203281
Characteristics of the heme catabolic pathway in mild unconjugated hyperbilirubinemia and their associations with inflammation and disease prevention., PMID:28389660
Tat-biliverdin reductase A protects INS-1 cells from human islet amyloid polypeptide-induced cytotoxicity by alleviating oxidative stress and ER stress., PMID:28198575
Genetic Variations in Bilirubin Metabolism Genes and Their Association with Unconjugated Hyperbilirubinemia in Adults., PMID:27943244
Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury., PMID:27634590
Predictive role BLVRA mRNA expression in hepatocellular cancer., PMID:27740521
Protective role of biliverdin against bile acid-induced oxidative stress in liver cells., PMID:27387768
An Integrated Clinico-transcriptomic Approach Identifies a Central Role of the Heme Degradation Pathway for Septic Complications after Trauma., PMID:26727089
Improvement of prognostic performance in severely injured patients by integrated clinico-transcriptomics: a translational approach., PMID:26607226
Evidences of Biological Functions of Biliverdin Reductase A in the Bovine Epididymis., PMID:26395865
Multiple Genetic Modifiers of Bilirubin Metabolism Involvement in Significant Neonatal Hyperbilirubinemia in Patients of Chinese Descent., PMID:26146841
Epididymosomes: a heterogeneous population of microvesicles with multiple functions in sperm maturation and storage., PMID:26112475
17α-Ethinylestradiol can disrupt hemoglobin catabolism in amphibians., PMID:25819740
Tat-biliverdin reductase A inhibits inflammatory response by regulation of MAPK and NF-κB pathways in Raw 264.7 cells and edema mouse model., PMID:25239864
Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells., PMID:25147500
Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis., PMID:23042203
A homozygous nonsense mutation (c.214C->A) in the biliverdin reductase alpha gene (BLVRA) results in accumulation of biliverdin during episodes of cholestasis., PMID:21278388
Biliverdin reductase A in the prevention of cellular senescence against oxidative stress., PMID:21099244
Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations., PMID:19243019
Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population., PMID:19238116
For research use only. Not for human or drug use.
