Catalog No.
YHE96601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu629-Glu894
Predicted molecular weight
32.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P52948
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
98 kDa nucleoporin, Nucleoporin Nup98, Nup98, Nuclear pore complex protein Nup98-Nup96, Nup96, Nucleoporin Nup96, ADAR2, 96 kDa nucleoporin, NUP98
Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia., PMID:40501735
Nuclearporin subcomplex Nup98/Rae1 is vital for maternal-to-zygotic transition during early embryonic development., PMID:40483744
Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51., PMID:40480227
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12., PMID:40389480
Loss of NOL10 leads to impaired disease progression of NUP98::DDX10 leukemia., PMID:40263434
Unbiased analysis of NUP98-KDM5A-induced murine leukemia reveals phenotypic heterogeneity recapitulating human disease subtypes., PMID:40258564
TRIM21-NUP98 Interface Accommodates Structurally Diverse Molecular Glue Degraders., PMID:40204658
Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance., PMID:40180954
HoxBlinc: a key driver of chromatin dynamics in NUP98 fusion-driven leukemia., PMID:40166939
Promising activity of Selinexor in the treatment of a patient with refractory NUP98-NSD1+/FLT3-ITD + acute myeloid leukemia., PMID:40100393
Mechanistic Insights Into 5'-tiRNA-His-GTG Mediated Activation of the JNK Pathway in Skin Photoaging., PMID:40097984
An ER-associated structure sequesters misassembled FG-rich nucleoporins to help maintain nuclear pore complex function., PMID:40079246
From low remission to hope: the efficacy of targeted therapies in NUP98-R positive pediatric acute myeloid leukemia., PMID:40016600
Enterovirus D68 2A protease causes nuclear pore complex dysfunction and motor neuron toxicity., PMID:39975337
NUP98-p65 complex regulates DNA repair to maintain glioblastoma stem cells., PMID:39960447
Biomolecular condensation of human IDRs initiates endogenous transcription via intrachromosomal looping or high-density promoter localization., PMID:39933697
The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators., PMID:39922194
Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemia., PMID:39920624
Monitoring measurable residual disease in NUP98::NSD1-positive acute myeloid leukemia., PMID:39902715
Detailed characterisation of the trypanosome nuclear pore architecture reveals conserved asymmetrical functional hubs that drive mRNA export., PMID:39899609
False positive NUP98 fluorescence in situ hybridization rearrangements in B-acute lymphoblastic leukemia., PMID:39892372
HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98-rearranged leukemia., PMID:39883527
Application of RNA-Based Next-Generation Sequencing Fusion Assay for Hematological Malignancies., PMID:39859151
Nuclear transport protein suppresses Tau neurodegeneration., PMID:39843141
IL-1R1 and IL-18 signals regulate mesenchymal stromal cells in an aged murine model of myelodysplastic syndromes., PMID:39841001
Clinicopathologic and Molecular Characterization of NUP98-Rearranged Acute Leukemias., PMID:39836982
Precision medicine for high-risk gene fusions in pediatric AML: a focus on KMT2A, NUP98, and GLIS2 rearrangements., PMID:39808803
Met58 and di-acidic motif located at C-terminal region of SARS-CoV-2 ORF6 plays a crucial role in its structural conformations., PMID:39724814
Landscape of somatic mutations and clonal evolution in NUP98-rearranged adult acute myeloid leukaemia., PMID:39701595
Progressive chromatin rewiring by ETO2::GLIS2 revealed in a genome-edited human iPSC model of pediatric leukemia initiation., PMID:39656971
Protein-Specific Crowding Accelerates Aging in Protein Condensates., PMID:39648588
Acute myeloid leukemia with NUP98::RARG rearrangement: a case report and review of the relevant literature., PMID:39630349
Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders., PMID:39488207
NUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive gene expression in AML., PMID:39475509
Systematic Evaluation and Application of IDR Domain-Mediated Transcriptional Activation of NUP98 in Saccharomyces cerevisiae., PMID:39469753
Diagnosis of invasive encapsulated follicular variant papillary thyroid carcinoma by protein-based machine learning., PMID:39440350
Rare Non-Cryptic NUP98 Rearrangements Associated With Myeloid Neoplasms and Their Poor Prognostic Impact., PMID:39344146
NUP98 oncofusions in myeloid malignancies: An update on molecular mechanisms and therapeutic opportunities., PMID:39323480
Distinct FLT3 Pathways Gene Expression Profiles in Pediatric De Novo Acute Lymphoblastic and Myeloid Leukemia with FLT3 Mutations: Implications for Targeted Therapy., PMID:39273530
Interdependence between Nuclear Pore Gatekeepers and Genome Caretakers: Cues from Genome Instability Syndromes., PMID:39273335
Targeted gene sequencing and transcriptome sequencing reveal characteristics of NUP98 rearrangement in pediatric acute myeloid leukemia., PMID:39223643
NUP98::NSD1 and FLT3/ITD co-expression is an independent predictor of poor prognosis in pediatric AML patients., PMID:39182032
Menin inhibitors in pediatric acute leukemia: a comprehensive review and recommendations to accelerate progress in collaboration with adult leukemia and the international community., PMID:39179671
NUP98 is rearranged in 5.0% of adult East Asian patients with AML., PMID:39158088
Treatment of three pediatric AML co-expressing NUP98-NSD1, FLT3-ITD, and WT1., PMID:39068406
HOXA9 Regulome and Pharmacological Interventions in Leukemia., PMID:39017854
Optical genome mapping improves the accuracy of classification, risk stratification, and personalized treatment strategies for patients with acute myeloid leukemia., PMID:39016111
NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation., PMID:38940430
CircNUP98 promotes the malignant behavior of glioma cells through the miR-520f-3p/ELK4 axis., PMID:38923578
Predicting human and viral protein variants affecting COVID-19 susceptibility and repurposing therapeutics., PMID:38902252
For research use only. Not for human or drug use.
