Catalog No.
YHE91501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu239-Thr506
Predicted molecular weight
31.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P52294
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KPNA1, SRP1-beta, Importin subunit alpha-5, RCH2, Karyopherin subunit alpha-1, Nucleoprotein interactor 1, RAG cohort protein 2, NPI-1
Structure-function insights into the dual role of African swine fever virus pB318L: A typical geranylgeranyl-diphosphate synthase and a nuclear import protein., PMID:40185233
Direct observation of importin α family member KPNA1 in axonal transport with or without a schizophrenia-related mutation., PMID:40010609
Integrated Computational Analysis Reveals Early Genetic and Epigenetic AML Susceptibility Biomarkers in Benzene-Exposed Workers., PMID:39940906
MAPK Signaling-Mediated RFNG Phosphorylation and Nuclear Translocation Restrain Oxaliplatin-Induced Apoptosis and Ferroptosis., PMID:39120977
Respiratory syncytial virus NS1 inhibits anti-viral Interferon-α-induced JAK/STAT signaling, by limiting the nuclear translocation of STAT1., PMID:38938568
A Kpna1-deficient psychotropic drug-induced schizophrenia model mouse for studying gene-environment interactions., PMID:38336912
Examining the molecular mechanisms of topiramate in alleviating insulin resistance: A study on C2C12 myocytes and 3T3L-1 adipocytes., PMID:38308786
Seneca Valley virus 3Cpro antagonizes type I interferon response by targeting STAT1-STAT2-IRF9 and KPNA1 signals., PMID:37819133
The E3 ubiquitin ligase CHIP drives monoubiquitylation-mediated nuclear import of the tumor suppressor PTEN., PMID:37676120
ΔNp63 Regulates Radioresistance in Human Head and Neck Squamous Carcinoma Cells., PMID:37623213
Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state., PMID:37055441
Karyopherin Subunit Alpha 1 Enhances the Malignant Behaviors of Colon Cancer Cells via Promoting Nuclear Factor-κB p65 Nuclear Translocation., PMID:37038032
3Cpro of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation., PMID:36921803
FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression., PMID:36857183
Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p., PMID:36569291
Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2., PMID:36366568
Decreased Expression of Karyopherin-α 1 is Related to the Malignant Degree of Cervical Cancer and is Critical for the Proliferation of Hela Cells., PMID:35991835
Porcine Epidemic Diarrhea Virus nsp7 Inhibits Interferon-Induced JAK-STAT Signaling through Sequestering the Interaction between KPNA1 and STAT1., PMID:35442061
Enterovirus A71 2B Inhibits Interferon-Activated JAK/STAT Signaling by Inducing Caspase-3-Dependent Karyopherin-α1 Degradation., PMID:34992585
PACS-1 contains distinct motifs for nuclear-cytoplasmic transport and interacts with the RNA-binding protein PTBP1 in the nucleus and cytosol., PMID:34822171
Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice., PMID:34767585
KPNA1 regulates nuclear import of NCOR2 splice variant BQ323636.1 to confer tamoxifen resistance in breast cancer., PMID:34709749
Orthogonal ubiquitin transfer reveals human papillomavirus E6 downregulates nuclear transport to disarm interferon-γ dependent apoptosis of cervical cancer cells., PMID:34662469
CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells., PMID:34022224
Mechanisms and consequences of Newcastle disease virus W protein subcellular localization in the nucleus or mitochondria., PMID:33441338
Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus., PMID:33087462
Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model., PMID:32882370
A new transcription factor ATG10S activates IFNL2 transcription by binding at an IRF1 site in HepG2 cells., PMID:31996071
Dissecting the Role of NF-κb Protein Family and Its Regulators in Rheumatoid Arthritis Using Weighted Gene Co-Expression Network., PMID:31824568
Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1., PMID:31772273
Porcine circovirus 3 Cap inhibits type I interferon signaling through interaction with STAT2., PMID:31697988
STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1., PMID:31575039
Protection from Endotoxin Shock by Selective Targeting of Proinflammatory Signaling to the Nucleus Mediated by Importin Alpha 5., PMID:31533951
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity., PMID:31488827
Nuclear Entry of CRTC1 as Druggable Target of Acquired Pigmentary Disorder., PMID:30809299
Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1., PMID:30540948
Development of oligonucleotide-based antagonists of Ebola virus protein 24 inhibiting its interaction with karyopherin alpha 1., PMID:29850750
Karyopherins regulate nuclear pore complex barrier and transport function., PMID:28864541
Local histone acetylation by ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy., PMID:28820290
Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles., PMID:28628637
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy., PMID:28552616
Enterovirus 71 suppresses interferon responses by blocking Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling through inducing karyopherin-α1 degradation., PMID:28455446
Antagonizing cytokine-mediated JAK-STAT signaling by porcine reproductive and respiratory syndrome virus., PMID:28069291
[The nuclear import of Newcastle disease virus matrix protein depends on KPNB1 and Ran protein]., PMID:29746765
Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons., PMID:28045133
VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability., PMID:27974555
Aptamers that bind specifically to human KPNA2 (importin-α1) and efficiently interfere with nuclear transport., PMID:27154959
The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1., PMID:27622275
Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import., PMID:27434733
Nuclear import of prototype foamy virus transactivator Bel1 is mediated by KPNA1, KPNA6 and KPNA7., PMID:27277550
For research use only. Not for human or drug use.
