Catalog No.
YHE89601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile182-Asp327
Predicted molecular weight
19.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51878
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Caspase-5, Protease ICH-3, Protease TY, ICE(rel)-III, ICH3, CASP5, CASP-5
Selenium deficiency is functionally linked with the molecular etiopathogenesis of necrotizing enterocolitis (NEC)., PMID:40459789
Transcriptomic and Immunopathological Profiles of Inflammasomes in Different Clinical Forms of American Cutaneous Leishmaniasis., PMID:40431153
Inhibition of hsa_circ_0003314 contributes to trophoblast cell migration and invasion and inhibits pyroptosis in preeclampsia., PMID:40377691
Comprehensive analysis of the role of Caspases in glioma., PMID:40032044
Overexpression of inflammatory human caspase-4 in relation to clinical severity of oral lichen planus., PMID:39979138
Biological characteristics, immune infiltration and drug prediction of PANoptosis related genes and possible regulatory mechanisms in inflammatory bowel disease., PMID:39814753
Pyroptosis in Endothelial Cells and Extracellular Vesicle Release in Atherosclerosis via NF-κB-Caspase-4/5-GSDM-D Pathway., PMID:39770410
Human macrophage response to the emerging enteric pathogen Aeromonas veronii: Inflammation, apoptosis, and downregulation of histones., PMID:39663607
Kaempferol alleviates rheumatoid arthritis through pyroptosis based on bioinformatics analysis and experimental validation., PMID:39616227
Ribonuclease inhibitor 1 emerges as a potential biomarker and modulates inflammation and iron homeostasis in sepsis., PMID:38951571
Caspase-5: Structure, Pro-Inflammatory Activity and Evolution., PMID:38785927
Transcriptomic analysis delineates preterm prelabor rupture of membranes from preterm labor in preterm fetal membranes., PMID:38443884
Identification of Pyroptosis-Related Genes Regulating the Progression of Chronic Rhinosinusitis with Nasal Polyps., PMID:38402873
Identification of apoptosis-related gene signatures as potential biomarkers for differentiating active from latent tuberculosis via bioinformatics analysis., PMID:38312744
The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage., PMID:38106412
Abelson Helper Integration Site 1 haplotypes and peripheral blood expression associates with lithium response and immunomodulation in bipolar patients., PMID:38036661
Pyroptosis burden is associated with anti-TNF treatment outcome in inflammatory bowel disease: new insights from bioinformatics analysis., PMID:37740137
The influence of pyroptosis-related genes on the development of chronic obstructive pulmonary disease., PMID:37194062
A pilot study on pyroptosis related genes in peripheral blood mononuclear cells of non-small cell lung cancer patients., PMID:37194012
Copper metabolism in cell death and autophagy., PMID:37055935
Association between single nucleotide variants and severe chronic pain in older adult patients after lower extremity arthroplasty., PMID:36895017
Comprehensive LncRNA and Potential Molecular Mechanism Analysis in Noninfectious Uveitis., PMID:36857067
[Associations of genetic variations in pyroptosis related genes with acute adverse events in postoperative rectal cancer patients receiving concurrent chemoradiotherapy]., PMID:36781235
Pyroptosis-Related Signature Predicts the Progression of Ulcerative Colitis and Colitis-Associated Colorectal Cancer as well as the Anti-TNF Therapeutic Response., PMID:36741232
In Silico Structural and Functional Analyses of NLRP3 Inflammasomes to Provide Insights for Treating Neurodegenerative Diseases., PMID:36726838
Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation., PMID:36482436
The Identification of Human Translational Biomarkers of Neuropathic Pain and Cross-Species Validation Using an Animal Model., PMID:36422814
A Novel Pyroptosis-Related Gene Signature for Predicting the Prognosis and the Associated Immune Infiltration in Colon Adenocarcinoma., PMID:35912258
Lipid A Variants Activate Human TLR4 and the Noncanonical Inflammasome Differently and Require the Core Oligosaccharide for Inflammasome Activation., PMID:35862709
Prognostic prediction of systemic immune-inflammation status for patients with colorectal cancer: a novel pyroptosis-related model., PMID:35836259
Development and Validation of Ischemic Events Related Signature After Carotid Endarterectomy., PMID:35372347
Inhibition of circular RNA circ_0138959 alleviates pyroptosis of human gingival fibroblasts via the microRNA-527/caspase-5 axis., PMID:35030963
Identification of the Pyroptosis-Related Gene Signature and Risk Score Model for Colon Adenocarcinoma., PMID:34938319
CASP5 and CR1 as potential biomarkers for Kawasaki disease: an Integrated Bioinformatics-Experimental Study., PMID:34895171
SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade., PMID:34747049
SbCASP4 improves salt exclusion by enhancing the root apoplastic barrier., PMID:34554320
Wedelolactone ameliorates Pseudomonas aeruginosa-induced inflammation and corneal injury by suppressing caspase-4/5/11/GSDMD-mediated non-canonical pyroptosis., PMID:34481822
Insoluble Vascular Amyloid Deposits Trigger Disruption of the Neurovascular Unit in Alzheimer's Disease Brains., PMID:33915754
Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death., PMID:33741688
Distinct Gene Expression Signatures Characterize Strong Clinical Responders Versus Nonresponders to Canakinumab in Children With Systemic Juvenile Idiopathic Arthritis., PMID:33452871
Anticancer active trifluoromethylated fused triazinones are safe for early-life stages of zebrafish (Danio rerio) and reveal a proapoptotic action., PMID:33390035
Identification of biomarkers predicting the chemotherapeutic outcomes of capecitabine and oxaliplatin in patients with gastric cancer., PMID:33029206
TYK2 licenses non-canonical inflammasome activation during endotoxemia., PMID:32929218
Mechanistic insights into the role of pyroptosis in rheumatoid arthritis., PMID:32830085
Comprehensive insights on pivotal prognostic signature involved in clear cell renal cell carcinoma microenvironment using the ESTIMATE algorithm., PMID:32311223
Deciphering Immune-Associated Genes to Predict Survival in Clear Cell Renal Cell Cancer., PMID:31886185
Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis., PMID:31570336
Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy., PMID:31201888
Integrating Bonded and Nonbonded Potentials in the Knowledge-Based Scoring Function for Protein Structure Prediction., PMID:31045366
Analysis of Inflammatory Gene Expression Profile of Peripheral Blood Leukocytes in Type 2 Diabetes., PMID:30961396
For research use only. Not for human or drug use.
