Catalog No.
YHE84201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe212-Leu434
Predicted molecular weight
27.17 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51617
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interleukin-1 receptor-associated kinase 1, IRAK1, IRAK, IRAK-1
In Silico Exploration of Natural Antioxidants for Sepsis Drug Discovery., PMID:40509176
Regulatory mechanism of viperin in the interferon signaling pathway of large yellow croaker: Characterization of the promoter region., PMID:40482876
Clustering Based on Innate Immunity Reveals Differential Dysregulation Based on Disease Severity in Myelodysplastic Neoplasms., PMID:40397075
The overexpression of miR-146a in hippocampal microglia via IRAK1/TRAF6/NF-κB pathway improves cognitive function in diabetic mice., PMID:40349816
Identifying Immune Response Protein Biomarkers in Parkinson's-Related Cognitive Impairment and Depression., PMID:40332667
IFITMs exhibit antiviral activity against Chikungunya and Zika virus infection via the alteration of TLRs and RLRs signaling pathways., PMID:40328864
Identification of soluble biomarkers that associate with distinct manifestations of long COVID., PMID:40307449
Gut microbiota dysbiosis triggered by salinity stress enhances systemic inflammation in spotted scat (Scatophagus argus)., PMID:40254087
Activation of IL1A/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin., PMID:40236066
MiR-146a engineered extracellular vesicles derived from mesenchymal stromal cells more potently attenuate ischaemia-reperfusion injury in lung transplantation., PMID:40195092
The role of miR-146a/IRAK1/JNK1 pathway in mediating the effects of Yiqi Congming decoction on dry eye: A mechanistic study in rat models., PMID:40188896
BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity., PMID:40178982
Tumor-Derived Exosomal circ_0020095 Promotes Colon Cancer Cell Proliferation and Metastasis by Inhibiting M1 Macrophage Polarization., PMID:40165503
Ion Currents Mediated by TRPA1 Channels in Freshly Dissociated Rat Articular Chondrocytes: Biophysical Properties and Regulation by Inflammatory Processes., PMID:40143111
Inhibition of JAK2/STAT3 by pacritinib synergizes with chemotherapy in esophageal carcinoma., PMID:40112935
BAP1 Represses Sequential Activation of IRAKs and NF-κB Signaling in Pancreatic Cancer., PMID:40083694
miR-146a is critical for orchestrating Mycobacterium fortuitum survival through anti-inflammatory and M2 macrophage responses in fish., PMID:40081436
SARS-CoV-2 Nsp13 helicase modulates miR-146a-mediated signaling pathways., PMID:40073498
[Duplication of the X-chromosomal Xq28 region containing the MECP2 gene in X-linked intellectual disability syndrome Lubs-type]., PMID:39987543
Pregnancy-induced changes in the toll-like receptor pathway in the ovine duodenum., PMID:39985901
A novel approach to metabolic profiling in case models of MECP2-related disorders., PMID:39945871
Interleukin 1 receptor associated kinase 1 gene polymorphism association with risk of rheumatological diseases in Egyptian population., PMID:39826020
CircCCT2/miR-146a-5p/IRAK1 axis promotes the development of head and neck squamous cell carcinoma., PMID:39810134
ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage., PMID:39753776
Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity., PMID:39653824
Revealing the molecular links between coronary heart disease and cognitive impairment: the role of aging-related genes and therapeutic potential of stellate ganglion block., PMID:39609308
Targeting IL-1/IRAK1/4 signaling in Acute Myeloid Leukemia Stem Cells Following Treatment and Relapse., PMID:39605740
Pacritinib prevents inflammation-driven myelofibrosis-like phenotype in a miR-146a-/- murine model., PMID:39603040
Identification of VISTA regulators in macrophages mediating cancer cell survival., PMID:39602545
Novel Inhibitory Actions of Neuroactive Steroid [3α,5α]-3-Hydroxypregnan-20-One on Toll-like Receptor 4-Dependent Neuroimmune Signaling., PMID:39595617
Identification of TAK-756, A Potent TAK1 Inhibitor for the Treatment of Osteoarthritis through Intra-Articular Administration., PMID:39576936
MicroRNA expression profiling in the adult offspring of rats with periodontal disease., PMID:39566203
Multi-gene duplication removal in an engineered human cellular MECP2 duplication syndrome model with an IRAK1-MECP2 duplication., PMID:39507402
Mesenchymal stem cell-derived extracellular vesicles reduce inflammatory responses to SARS-CoV-2 and Influenza viral proteins via miR-146a/NF-κB pathway., PMID:39496662
Interleukin-1 Receptor-Associated Kinase 1 in Cancer Metastasis and Therapeutic Resistance: Mechanistic Insights and Translational Advances., PMID:39451208
MiR-146a Is Mutually Regulated by High Glucose-Induced Oxidative Stress in Human Periodontal Ligament Cells., PMID:39409031
Hyperactivation of NF-κB signaling in splicing factor mutant myelodysplastic syndromes and therapeutic approaches., PMID:39406588
Pacritinib Response Is Associated With Overall Survival in Myelofibrosis: PERSIST-2 Landmark Analysis of Survival., PMID:39400386
High-throughput screening identified pacritinib as a promising therapeutic approach to overcome lenvatinib resistance in hepatocellular carcinoma by targeting IRAK1., PMID:39378786
MiR-146a-5p engineered hucMSC-derived extracellular vesicles attenuate Dermatophagoides farinae-induced allergic airway epithelial cell inflammation., PMID:39364406
Severe invasive infections linked to IRAK2 immune variants., PMID:39299377
Artemisinin attenuates perinatal inflammation and consequent oxidative stress in oligodendrocyte precursor cells by inhibiting IRAK-4 and IRAK-1., PMID:39293313
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways., PMID:39283364
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome., PMID:39242551
Activation of NF-κB/MAPK signaling and induction of apoptosis by salicylate synthase NbtS in Nocardia farcinica promotes neuroinflammation development., PMID:39240104
MACC1 enhances an oncogenic RNA splicing of IRAK1 through interacting with HNRNPH1 in lung adenocarcinoma., PMID:39221900
Melittin Alleviates Oxidative Stress Injury in Schwann Cells by Targeting Interleukin-1 Receptor Type 1 to Downregulate Nuclear Factor Kappa B-Mediated Inflammatory Response In Vitro., PMID:39211643
Nandrolone decanoate induced kidney injury through miRNA-146a targeting IRAK1 and TRAF6 via activation of the NF-κB pathway: The effect of moderate exercise., PMID:39208922
In pancreatic cancer patients, chemotherapy reshapes the gene expression profile and antigen receptor repertoire of T lymphocytes and enhances their effector response to tumor-associated antigens., PMID:39176093
The complex effects of miR-146a in the pathogenesis of Alzheimer's disease., PMID:39075895
For research use only. Not for human or drug use.
