Catalog No.
YHE84001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys177
Predicted molecular weight
21.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51608
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MeCp2, MeCp-2 protein, Methyl-CpG-binding protein 2, MECP2
Medical Biases and Misconceptions Impact Diagnoses in Males With Loss of Function MECP2 Variants., PMID:40515634
Molecular Insights into Neurological Regression with a Focus on Rett Syndrome-A Narrative Review., PMID:40508170
Engineering novel CRISPRi repressors for highly efficient mammalian gene regulation., PMID:40506744
Female cortical cellular mosaicism underlies shared MeCP2 and PCB impacted gene pathways., PMID:40501678
CHD8 Variant and Rett Syndrome: Overlapping Phenotypes, Molecular Convergence, and Expanding the Genetic Spectrum., PMID:40496977
Altered Expression of MeCP2 and PTEN Genes in the Molecular Basis of Specific Learning Disorder., PMID:40478485
Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapy., PMID:40463103
Potentiation of group III metabotropic glutamate receptors positively affects neurophysiological features in a mouse model of Rett syndrome., PMID:40446468
Rett Syndrome: Thinking Beyond Brain Borders., PMID:40442389
Neuronal Plasticity-Dependent Paradigm and Young Plasma Treatment Prevent Synaptic and Motor Deficit in a Rett Syndrome Mouse Model., PMID:40427641
MECP2 mRNA Profile in Brain Tissues from a Rett Syndrome Patient and Three Human Controls: Mutated Allele Preferential Transcription and In Situ RNA Mapping., PMID:40427580
A Computational Approach to Identify Novel Protein Targets Uncovers New Potential Mechanisms of Action of Mirtazapine S(+) and R(-) Enantiomers in Rett Syndrome., PMID:40417780
MECP2 duplication syndrome: Recent advances in pathophysiology and therapeutic perspectives., PMID:40382977
Interpreting the rich dialogue between astrocytes and neurons: An overview in Rett syndrome., PMID:40378493
[A case of complex structural variants in the Xq28 region diagnosed by whole genome sequencing]., PMID:40372229
Exploring the complexity of MECP2 function in Rett syndrome., PMID:40360671
MeCP2 and non-CG DNA methylation stabilize the expression of long genes that distinguish closely related neuron types., PMID:40355611
Uncovering the Molecular Interactions Underlying MBD2 and MBD3 Phase Separation., PMID:40350613
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model., PMID:40313754
MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis., PMID:40271828
CRISPR/Cas-mediated mRNA knockdown in the embryos of Xenopus tropicalis., PMID:40270035
Early neural dysfunction reflected in degraded auditory cortex responses in pre-regression heterozygous Mecp2 rats., PMID:40262725
Changes in histone abundance and post-translational modifications in Rana [Lithobates] catesbeiana tissues during temperature-mediated thyroid hormone-induced metamorphosis., PMID:40262239
SRSF9-Mediated Exon Recognition Promotes Exon 2 Inclusion in Mecp2 Pre-mRNA Alternative Splicing., PMID:40244165
Human-Specific Organization of Proliferation and Stemness in Squamous Epithelia: A Comparative Study to Elucidate Differences in Stem Cell Organization., PMID:40243939
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model., PMID:40196492
Middle-Aged Women With Rett Syndrome: Longitudinal Profile From the British Isles Rett Syndrome Survey and Suggestions for Care., PMID:40194792
MeCP2 Modulates Depression-Like Behaviors Comorbid to Chronic Pain by Regulating Adult Hippocampal Neurogenesis., PMID:40193046
Autistic-like behaviors and impaired chronic inflammatory pain in primary nociceptive neuron-specific deletion of Mecp2 or Fmr1 knockout male mice., PMID:40174753
Self-regulating gene therapy ameliorates phenotypes and overcomes gene dosage sensitivity in a mouse model of Rett syndrome., PMID:40173263
Diffuse but Non-homogeneous Brain Atrophy: Identification of Specific Brain Regions and Their Correlation with Clinical Severity in Rett Syndrome., PMID:40147315
Ferulic acid in Chaihu Shugan San modulates depression-like behavior, endothelial and gastrointestinal dysfunction in rats via the Ghrl-Edn1/Mecp2/P-mTOR/VEGFA pathway: A multi-omics study., PMID:40127829
Rescue of respiratory and cognitive impairments in Rett Syndrome mice using NLX-101, a selective 5-HT1A receptor biased agonist., PMID:40121895
MeCP2 promotes keloid progression by regulating ADAM12 expression and Wnt/β-catenin pathway., PMID:40119949
Unique DUP-TRP/INV-DUP Structure Detected by Long-Read Sequencing., PMID:40070183
Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay., PMID:40063648
CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity., PMID:40060544
Correction to "Imbalance between hippocampal projection cell and parvalbumin interneuron architecture increases epileptic susceptibility in mouse model of methyl CpG binding protein 2 duplication syndrome"., PMID:40035127
Jieyu Guben decoction alleviates combined allergic rhinitis and asthma syndrome by balancing Th17/Treg expression and restoring PPARD., PMID:40031093
Potentiation of the M1 muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity in Mecp2+/- mice., PMID:40021095
Cell type-specific 3D-genome organization and transcription regulation in the brain., PMID:40009678
Novel Detection and Clinical Utility of Serum-Derived Extracellular Vesicle in Angiosarcoma., PMID:40001341
[Duplication of the X-chromosomal Xq28 region containing the MECP2 gene in X-linked intellectual disability syndrome Lubs-type]., PMID:39987543
The methyl-CpG-binding protein 2 (Mecp2) regulates the hypothalamic mitochondrial function and white adipose tissue lipid metabolism., PMID:39983816
A novel approach to metabolic profiling in case models of MECP2-related disorders., PMID:39945871
Integrated Computational Analysis Reveals Early Genetic and Epigenetic AML Susceptibility Biomarkers in Benzene-Exposed Workers., PMID:39940906
NEAT1-mediated regulation of proteostasis and mRNA localization impacts autophagy dysregulation in Rett syndrome., PMID:39921568
Rapid Whole Genome Sequencing Uncovers a Triple Diagnosis: X-Linked Chondrodysplasia Punctata, MECP2-Related Disorder, and Mosaic Jacobs Syndrome., PMID:39908167
Unveiling Molecular Dynamics of MeCp2, CDKL5 and BDNF in the Hippocampus of Individuals With Intractable Mesial Temporal Lobe Epilepsy., PMID:39888294
For research use only. Not for human or drug use.
