Catalog No.
YHE81801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser2-Pro185
Predicted molecular weight
22.66 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51452
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dual specificity protein phosphatase 3, VHR, Vaccinia H1-related phosphatase, Dual specificity protein phosphatase VHR, DUSP3
The emerging role of dual specificity phosphatase 3 in melanocytic cancer: from oncogenesis to clinical value., PMID:40485572
Piezo1 activation protects against sepsis-induced myocardial dysfunction in a pilot study., PMID:40341084
Knockdown of dual-specificity phosphatase 3 drives differentiation and polarization of myeloid leukemia cells into macrophages with reduced proliferative and DNA repair fitness., PMID:40334397
Differential aortic aneurysm formation provoked by chemogenetic oxidative stress., PMID:40100302
The Significance of Cellular Senescence Hub Genes in the Diagnosis and Subtype Classification of a Comprehensive Database of Gene Expression in Intervertebral Disc Degeneration., PMID:40061887
Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR (DUSP3) Phosphatase., PMID:39959108
Targeting DUSP3 promotes cell senescence by activating the notch1 pathway to treat hepatocellular carcinoma., PMID:39954561
USC-Derived Small Extracellular Vesicles-Functionalized Scaffolds Promote Scarless Vaginal Defect Repair via Delivery of Decorin and DUSP3 Proteins., PMID:39931530
TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3., PMID:39849581
FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia., PMID:39837840
DUSP3 restrains the progression and stemness property of osteosarcoma through regulating EGFR/STAT3/SOX2 axis., PMID:39744427
Genome-wide characterization and comparative expression profiling of dual-specificity phosphatase genes in yellow catfish (Pelteobagrus fulvidraco) after infection with exogenous Aeromonas hydrophila., PMID:39606227
The Dual-specificity Phosphatase 3 (DUSP3): A Potential Target Against Renal Ischemia/Reperfusion Injury., PMID:39466786
Assessment of transcriptional markers for the differentiation of Mycobacterium mungi infection status in free-ranging banded mongoose (Mungos mungo)., PMID:39293135
FOSL1-mediated LINC01566 negatively regulates CD4+ T-cell activation in myasthenia gravis., PMID:39113081
Gastric cancer cell-derived exosomal miR-541-5p induces M2 macrophage polarization through DUSP3/JAK2/STAT3 pathway., PMID:39103776
Exercise training-driven exosomal miRNA-323-5p activity suppresses adipogenic conversion of 3T3-L1 cells via the DUSP3/ERK pathway., PMID:39083976
Dehydroandrographolide facilitates M2 macrophage polarization by downregulating DUSP3 to inhibit sepsis-associated acute kidney injury., PMID:38629726
Expression profile of mRNAs and miRNAs related to mitogen-activated kinases in HaCaT cell culture treated with lipopolysaccharide a and adalimumab., PMID:38557266
DUSP3 modulates IRES-dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus., PMID:38538536
l-Methionine potentiates anticancer activity of Sorafenib by epigenetically altering DUSP3/ERK pathway in hepatocellular carcinoma., PMID:38367245
The Ability of a 3-Gene Host Signature in Blood to Distinguish Tuberculous Meningitis From Other Brain Infections., PMID:38169323
Anti-Inflammatory Effect of High-Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis., PMID:38111131
Targeting Cartilage miR-195/497 Cluster for Osteoarthritis Treatment Regulates the Circadian Clock., PMID:37827130
Cold Stress Induces Apoptosis in Silver Pomfret via DUSP-JNK Pathway., PMID:37658990
Revisiting VH1 phosphatase at the time of monkeypox: back to the spotlight., PMID:37409507
Dual Specificity Phosphatase 3 (DUSP3) Knockdown Alleviates Acute Myocardial Infarction Damage via Inhibiting Apoptosis and Inflammation., PMID:37272465
Protein Tyrosine Phosphatase Biochemical Inhibition Assays., PMID:36248604
Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity., PMID:36101856
The role of dual-specificity phosphatase 3 in melanocytic oncogenesis., PMID:35899430
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction., PMID:35705979
Revealing potential diagnostic gene biomarkers of septic shock based on machine learning analysis., PMID:35045818
Does renal ischaemia/reperfusion injury bite the DUSP3?, PMID:34978749
The genetic deletion of the Dual Specificity Phosphatase 3 (DUSP3) attenuates kidney damage and inflammation following ischaemia/reperfusion injury in mouse., PMID:34704357
The apoptosis mechanisms of HepG2 cells induced by bitter melon seed., PMID:33844303
Nucleophosmin Protein Dephosphorylation by DUSP3 Is a Fine-Tuning Regulator of p53 Signaling to Maintain Genomic Stability., PMID:33777934
Dual-specificity phosphatase 3 deletion promotes obesity, non-alcoholic steatohepatitis and hepatocellular carcinoma., PMID:33712680
UV Radiation-induced Impairment of Cellular Morphology and Motility is Enhanced by DUSP3/VHR Loss and FAK Activation., PMID:33479884
Regulation of signal transducer and activator of transcription 3 activation by dual-specificity phosphatase 3., PMID:32475380
DUSP3 maintains genomic stability and cell proliferation by modulating NER pathway and cell cycle regulatory proteins., PMID:32380926
Allosteric Impact of the Variable Insert Loop in Vaccinia H1-Related (VHR) Phosphatase., PMID:32348128
The specificity protein 3 (SP3) gene in ducks (Anas platyrhynchos): cloning, characterization and expression during viral infection., PMID:32180490
Ochratoxin A Sequentially Activates Autophagy and the Ubiquitin-Proteasome System., PMID:31653047
Transcriptome stability profiling using 5'-bromouridine IP chase (BRIC-seq) identifies novel and functional microRNA targets in human melanoma cells., PMID:31179855
Revisiting the roles of VHR/DUSP3 phosphatase in human diseases., PMID:30208163
DUSP3/VHR: A Druggable Dual Phosphatase for Human Diseases., PMID:30069819
Identification of serum miR-1915-3p and miR-455-3p as biomarkers for breast cancer., PMID:30048472
Lung Cancer Therapy Targeting Histone Methylation: Opportunities and Challenges., PMID:30002791
Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner., PMID:29020102
Diagnostic accuracy of a selected signature gene set that discriminates active pulmonary tuberculosis and other pulmonary diseases., PMID:28941629
For research use only. Not for human or drug use.
