Catalog No.
YHE80001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile26-Ala257
Predicted molecular weight
27.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51124
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hu-Met-1, Granzyme M, Natural killer cell granular protease, Met-1 serine protease, Met-ase, GZMM, MET1
Downregulated granzyme M expression: implications for the immune system and prognosis of thyroid cancer., PMID:40228756
Integrated Approach for Biomarker Discovery and Mechanistic Insights into the Co-Pathogenesis of Type 2 Diabetes Mellitus and Non-Hodgkin Lymphoma., PMID:39906693
Granzyme mRNA-miRNA interaction and its implication to functional impact., PMID:39528794
Identification of hub modules and therapeutic targets associated with CD8+T-cells in HF and their pan-cancer analysis., PMID:39138291
Single-cell RNA sequencing comparison of CD4+, CD8+ and T-cell receptor γδ+ cutaneous T-cell lymphomas reveals subset-specific molecular phenotypes., PMID:39133553
Peripheral Blood CD8+ T-Lymphocyte Immune Response in Benign and Subpopulations of Breast Cancer Patients., PMID:38928129
Cytotoxic CD4+ T Cells Are Induced during Infection with Chlamydia trachomatis., PMID:38905023
Tumor and Peritoneum-Associated Macrophage Gene Signature as a Novel Molecular Biomarker in Gastric Cancer., PMID:38612926
Exploring the cross-cancer effect of circulating proteins and discovering potential intervention targets for 13 site-specific cancers., PMID:38039160
Preferential differential gene expression within the WC1.1+ γδ T cell compartment in cattle naturally infected with Mycobacterium bovis., PMID:37942326
Identification of the prognostic immune subtype in copy-number high endometrial cancer., PMID:37857563
Single-cell RNA sequencing reveals the transcriptomic characteristics of peripheral blood mononuclear cells in hepatitis B vaccine non-responders., PMID:37593735
Concentration of non-myocyte proteins in arterial media of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy., PMID:36753487
MAIT cells accumulate in ovarian cancer-elicited ascites where they retain their capacity to respond to MR1 ligands and cytokine cues., PMID:34854949
Decreased expression of T-cell-associated immune markers predicts poor prognosis in patients with follicular lymphoma., PMID:34837284
Consensus gene modules related to levels of bone mineral density (BMD) among smokers and nonsmokers., PMID:34743649
Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control., PMID:34084172
Cytotoxic Lymphocytes Target HIV-1 Gag Through Granzyme M-Mediated Cleavage., PMID:33953729
A Deadly Cargo: Gene Repertoire of Cytotoxic Effector Proteins in the Camelidae., PMID:33669939
Waiting in the wings: RUNX3 reveals hidden depths of immune regulation with potential implications for inflammatory bowel disease., PMID:33528856
Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells., PMID:33202767
The Multifaceted Function of Granzymes in Sepsis: Some Facts and a Lot to Discover., PMID:32655547
Fish Granzyme A Shows a Greater Role Than Granzyme B in Fish Innate Cell-Mediated Cytotoxicity., PMID:31736981
Proteome analysis of human CD56neg NK cells reveals a homogeneous phenotype surprisingly similar to CD56dim NK cells., PMID:29999523
Protease-Mediated Suppression of DRG Neuron Excitability by Commensal Bacteria., PMID:29089436
Gene Expression Signatures in Circulating Tumor Cells Correlate with Response to Therapy in Metastatic Breast Cancer., PMID:28778937
DACH1 suppresses breast cancer as a negative regulator of CD44., PMID:28659634
Granzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis., PMID:28338658
Granzyme M has a critical role in providing innate immune protection in ulcerative colitis., PMID:27441655
Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation., PMID:25788270
Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach., PMID:25143259
NK cell intrinsic regulation of MIP-1α by granzyme M., PMID:24625974
Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation., PMID:24316590
Granzyme M cannot induce cell death via cleavage of mouse FADD., PMID:23354943
FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade., PMID:21979465
Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death., PMID:21857942
Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71., PMID:21059895
A role for granzyme M in TLR4-driven inflammation and endotoxicosis., PMID:20585036
Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells., PMID:20406824
Granzyme M: characterization with sites of post-translational modification and specific sites of interaction with substrates and inhibitors., PMID:20107908
Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M., PMID:19542453
NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network., PMID:18523284
Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis., PMID:17513296
The expression of the novel cytotoxic protein granzyme M by large granular lymphocytic leukaemias of both T-cell and NK-cell lineage: an unexpected finding with implications regarding the pathobiology of these disorders., PMID:17408463
Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation., PMID:16818775
Serpins prevent granzyme-induced death in a species-specific manner., PMID:16405655
KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity., PMID:16219538
Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes., PMID:16186162
Functional analysis of granzyme M and its role in immunity to infection., PMID:16116214
Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B., PMID:15494398
For research use only. Not for human or drug use.
