Catalog No.
YHE78001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr95-Gly281
Predicted molecular weight
23.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P50591
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Apo-2 ligand, CD253, Tumor necrosis factor ligand superfamily member 10, TRAIL, APO2L, TNFSF10, Protein TRAIL, Apo-2L, TNF-related apoptosis-inducing ligand
lncRNA PTCSC1 Promotes TRAIL Resistance through FOXO3a Pathway in HCT116 and SW480 Cells., PMID:40493899
TRAIL (DR5) receptor and the modulation of TRAIL pathway in PLWHIV: key mechanisms in the progression of HIV disease., PMID:40452022
Chaetocin enhances tumor necrosis factor‑related apoptosis‑inducing ligand‑mediated apoptosis by enhancing DR5 stabilization and reactive oxygen species generation in human glioblastoma cells., PMID:40377008
Protein Nanoparticles Simultaneously Displaying TRAIL and EGFR-Binding Ligands Effectively Induce Apoptotic Cancer Cell Death and Overcome EGFR-TKI Resistance in Lung Cancer., PMID:40237189
Inducing Cancer Cell Killing Using DNA Nanostructure-Mediated Superclustering of Death Receptors., PMID:40197050
TRAIL induces cytokine production via the NFkB2 pathway promoting neutrophil chemotaxis and neutrophil-mediated immune-suppression in triple negative breast cancer cells., PMID:40187604
Cascade-Targeting Apoptosis via Synergy of TRAIL-Specific Bystander Effect and Mitochondrial Photodamage in Cancer Therapy., PMID:40151999
Targeting RBM39 with Tasisulam enhances TRAIL-induced apoptosis through DR5 upregulation and Bcl-2 downregulation in renal cell carcinoma., PMID:40112928
Low extracellular pH enhances TRAIL-induced apoptosis by downregulating Mcl-1 expression., PMID:40024506
Evaluation of rs781673405, rs1244378045, rs767450259, rs750556128, rs369143448, rs143353036, and rs759369504 mutations in terms of polymorphism in diabetic obese and non-diabetic obese individuals., PMID:39985597
Applying Ultrasound to Mechanically and Noninvasively Sensitize Prostate Tumors to TRAIL-Mediated Apoptosis., PMID:39976192
Exploring the dynamic role of circulating soluble tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a diagnostic and prognostic marker; a review., PMID:39923464
OPG and BAFF as predictive biomarkers of the severity of SARS-CoV-2 infection., PMID:39888266
Production of an Oncolytic Adeno-Associated Virus Containing the Pro-Apoptotic TRAIL Gene Can Be Improved by shRNA Interference., PMID:39859285
Circulating inflammatory cytokines and colorectal cancer: New insights from Mendelian randomization., PMID:39854755
Mcl-1 is a Gatekeeper Molecule to Regulate the Crosstalk Between Ferroptotic Agent-Induced ER Stress and TRAIL-Induced Apoptosis., PMID:39853862
Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins., PMID:39740038
[Association of tumor necrosis factor related apoptosis inducing ligand (TRAIL) gene polymorphism with susceptibility to diabetes periodontitis]., PMID:39719839
Improving Targeted Delivery and Antitumor Efficacy of TRAIL through Fusion with a B7H3-Antagonistic Affibody., PMID:39620978
MOTS-c relieves hepatocellular carcinoma resistance to TRAIL-induced apoptosis under hypoxic conditions by activating MEF2A., PMID:39581216
TRAIL induces podocyte PANoptosis via death receptor 5 in diabetic kidney disease., PMID:39571905
CARD16 restores tumorigenesis and restraints apoptosis in glioma cells Via FOXO1/TRAIL axis., PMID:39516471
Urinary interferon-γ-induced protein-10/creatinine ratio as a predictor of severe paediatric infections: A prospective pilot study., PMID:39508142
Metformin induces apoptosis in TRAIL-resistant colorectal cancer cells., PMID:39500444
Cisplatin-encapsulated TRAIL-engineered exosomes from human chorion-derived MSCs for targeted cervical cancer therapy., PMID:39497209
Exploring Causal Correlations Between Inflammatory Cytokines and Kawasaki Disease: A Mendelian Randomization., PMID:39485066
Remodeling tumor microenvironment using pH-sensitive biomimetic co-delivery of TRAIL/R848 liposomes against colorectal cancer., PMID:39449815
The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL., PMID:39365855
Vascular Cytokines and Atherosclerosis: Differential Serum Levels of TRAIL, IL-18, and OPG in Obstructive Coronary Artery Disease., PMID:39334884
Defining age-specific reference intervals for biomarkers distinguishing bacterial from viral infection in paediatrics., PMID:39313063
The Innate Immune System and the TRAIL-Bcl-XL Axis Mediate a Sex Bias in Lung Cancer and Confer a Therapeutic Vulnerability in Females., PMID:39312191
Evaluating TRAIL and IP-10 alterations in vaccinated pregnant women after COVID-19 diagnosis and their correlation with neutralizing antibodies., PMID:39290698
IL-8 and PI3K pathway influence the susceptibility of TRAIL-sensitive colorectal cancer cells to TRAIL-induced cell death., PMID:39269555
Combining gemcitabine and MSC delivering soluble TRAIL to target pancreatic adenocarcinoma and its stroma., PMID:39168103
Acquired Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Resistance of Human Colorectal Cancer Cells Is Linked to Histone Acetylation and Is Synergistically Ameliorated by Combination with HDAC Inhibitors., PMID:39090444
Protocol for analyzing TRAIL- and Fas-induced signaling complexes by immunoprecipitation from human cells., PMID:39088326
Using blood TNF-related apoptosis-inducing ligand levels to discriminate between viral and bacterial infections: A prospective observational study., PMID:39032319
Endometriotic Tissue-derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis., PMID:38984872
Licochalcone D exhibits cytotoxicity in breast cancer cells and enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis through upregulation of death receptor 5., PMID:38937960
Fisetin reduces the resistance of MOLT-4 and K562 cells to TRAIL-induced apoptosis through upregulation of TRAIL receptors., PMID:38918236
Cytoplasmic TP53INP2 acts as an apoptosis partner in TRAIL treatment: the synergistic effect of TRAIL with venetoclax in TP53INP2-positive acute myeloid leukemia., PMID:38909249
Auto-loaded TRAIL-exosomes derived from induced neural stem cells for brain cancer therapy., PMID:38908756
ELF3 plays an important role in defining TRAIL sensitivity in breast cancer by modulating the expression of decoy receptor 2 (DCR2)., PMID:38787503
Proteomic mapping identifies serum marker signatures associated with MIS-C specific hyperinflammation and cardiovascular manifestation., PMID:38723855
Glutamine-mediated epigenetic regulation of cFLIP underlies resistance to TRAIL in pancreatic cancer., PMID:38684915
Pro-Inflammatory Activation Suppresses TRAIL-induced Apoptosis of Acute Myeloid Leukemia Cells., PMID:38648763
Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis., PMID:38636395
Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement., PMID:38562920
Antagonistic effects of the cytotoxic molecules granzyme B and TRAIL in the immunopathogenesis of sclerosing cholangitis., PMID:38441998
Aponermin: First Approval., PMID:38441805
For research use only. Not for human or drug use.
