Catalog No.
YHE77801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2-Tyr478
Predicted molecular weight
55.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P50579
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Peptidase M, p67eIF2, Methionine aminopeptidase 2, MetAP 2, Initiation factor 2-associated 67 kDa glycoprotein, P67EIF2, METAP2, p67, MAP 2, MNPEP
A phase 1 safety study of evexomostat (SDX-7320) in late-stage cancer patients: an anti-angiogenic, insulin-sensitizing drug conjugate targeting MetAP2., PMID:40444533
Multiomics profiles of genome-wide alterations in H3K27ac in different lung lobes after acute graft-versus-host disease with MSCs treatment., PMID:40443676
Design and synthesis of thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen as potential MetAP (type II) inhibitors., PMID:40345475
Methionine Aminopeptidase 2 (MetAP2) Inhibitor BL6 Attenuates Inflammation in Cultured Microglia and in a Mouse Model of Alzheimer's Disease., PMID:39942725
Inhibition of methionine aminopeptidase in C2C12 myoblasts disrupts cell integrity via increasing endoplasmic reticulum stress., PMID:39814187
MetAP2 as a Therapeutic Target for Obesity and Type 2 Diabetes: Structural Insights, Mechanistic Roles, and Inhibitor Development., PMID:39766279
Design and optimization strategies of PROTACs and its Application, Comparisons to other targeted protein degradation for multiple oncology therapies., PMID:39591691
Biological control of nosemosis in Apis mellifera L. with Acacia nilotica extract., PMID:39550385
Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers., PMID:39325823
Targeted protein relocalization via protein transport coupling., PMID:39294374
Prevention of prostate cancer metastasis by a CRISPR-delivering nanoplatform for interleukin-30 genome editing., PMID:39244641
Methionine aminopeptidases: Potential therapeutic target for microsporidia and other microbes., PMID:39036929
Molecular characterization and phylogenetic analyses of MetAP2 gene and protein of Nosema bombycis isolated from Guangdong, China., PMID:39005720
Pharmacological Characterization of SDX-7320/Evexomostat: A Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-tumor and Anti-metastatic Activity., PMID:38530115
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons., PMID:38335281
The role of differentially expressed genes and immune cell infiltration in the progression of nonalcoholic steatohepatitis (NASH) to hepatocellular carcinoma (HCC): a new exploration based on bioinformatics analysis., PMID:38319987
Deciphering neuroprotective mechanism of nitroxoline in cerebral ischemia: network pharmacology and molecular modeling-based investigations., PMID:38233690
Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models., PMID:37940144
Preclinical Pharmacokinetics and Translational Pharmacokinetic/Pharmacodynamic Modeling of M8891, a Potent and Reversible Inhibitor of Methionine Aminopeptidase 2., PMID:37798538
Fumagillin regulates stemness and malignancies in cancer stem-like cells derived from liver cancer via targeting to MetAP-2., PMID:37506053
Neuroprotective Effect of Dexmedetomidine on Cerebral Ischemia-Reperfusion Injury in Rats., PMID:37235497
Identification of Potential Druggable Targets and Structure-Based Virtual Screening for Drug-like Molecules against the Shrimp Pathogen Enterocytozoon hepatopenaei., PMID:36674953
PROTAC: A Novel Drug Delivery Technology for Targeting Proteins in Cancer Cells., PMID:36321238
Bioinformatics Analysis of Common Genetic and Molecular Traits and Association of Portal Hypertension with Pulmonary Hypertension., PMID:36312597
Construction of the coexpression network involved in the pathogenesis of thyroid eye disease via bioinformatics analysis., PMID:36076300
RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells., PMID:35673573
Methionine aminopeptidase‑2 is a pivotal regulator of vasculogenic mimicry., PMID:34913067
Aspergillus fumigatus Fumagillin Contributes to Host Cell Damage., PMID:34829223
Identification of New Rare Variants Associated With Familial Autoimmune Thyroid Diseases by Deep Sequencing of Linked Loci., PMID:34143178
Potential inhibitors of methionine aminopeptidase type II identified via structure-based pharmacophore modeling., PMID:33846894
Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen., PMID:33810334
Hypoxia-Induced LIN28A mRNA Promotes the Metastasis of Colon Cancer in a Protein-Coding-Independent Manner., PMID:33665193
MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease., PMID:33661300
Inhibition of the invasion and metastasis of mammary carcinoma cells by NBD peptide targeting S100A4 via the suppression of the Sp1/MMP‑14 axis., PMID:33650647
In Vivo Imaging of Methionine Aminopeptidase II for Prostate Cancer Risk Stratification., PMID:33637565
The methionine aminopeptidase 2 inhibitor, TNP-470, enhances the antidiabetic properties of sitagliptin in mice by upregulating xenin., PMID:33279496
Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives., PMID:32998089
Maturation of NAA20 Aminoterminal End Is Essential to Assemble NatB N-Terminal Acetyltransferase Complex., PMID:32976911
CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2., PMID:32922205
Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight 'molecular budget'., PMID:32919012
Antitumor Activity and Mechanism of Robustic Acid from Dalbergia benthami Prain via Computational Target Fishing., PMID:32867345
The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis., PMID:32708166
MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity., PMID:31877115
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC., PMID:31741433
Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer., PMID:31725285
Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors., PMID:31537613
Structural features of methionine aminopeptidase2-active core peptide essential for binding with S100A4., PMID:31284952
A MetAP2 inhibitor blocks adipogenesis, yet improves glucose uptake in cells., PMID:31264515
Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (Type II)., PMID:31203805
MetAP2 inhibition increases energy expenditure through direct action on brown adipocytes., PMID:31048375
For research use only. Not for human or drug use.
