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Research Grade Ligelizumab

Catalog #:   DHJ92702 Specific References (85) DATASHEET
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHJ92702

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

Ig epsilon chain C region, IGHE, Ig epsilon chain C region ND, Immunoglobulin heavy constant epsilon

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01854

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CL-2C, CAS: 1322627-61-1

Clone ID

Ligelizumab

Data Image
  • SDS-PAGE
    SDS PAGE for Ligelizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Ligelizumab for Chronic Spontaneous Urticaria, PMID: 31577874

The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab, PMID: 31913280

Ligelizumab for the treatment of chronic spontaneous urticaria, PMID: 32380864

Ligelizumab for Chronic Spontaneous Urticaria, PMID: 32023385

Ligelizumab for chronic spontaneous urticaria, PMID: 32002982

Ligelizumab for Chronic Spontaneous Urticaria, PMID: 32023384

Ligelizumab for Chronic Spontaneous Urticaria. Reply, PMID: 32023387

Ligelizumab for Chronic Spontaneous Urticaria. Reply, PMID: 32023386

Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects, PMID: 25200415

Ligelizumab Is Superior to Omalizumab for Chronic Spontaneous Urticaria, PMID: 32208012

New treatments for chronic urticaria, PMID: 31446134

Antibodies to watch in 2021, PMID: 33459118

Current and emerging treatments for chronic spontaneous urticaria, PMID: 31494233

Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy, PMID: 32037590

High-Dose Omalizumab versus Ligelizumab for the Treatment of Chronic Spontaneous Urticaria: Do Not We Need a Head-To-Head Comparison?, PMID: 33321510

Ligelizumab treatment for severe asthma: learnings from the clinical development programme, PMID: 33747510

Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses, PMID: 27185571

Novel Therapeutic Approaches and Targets for Treatment of Chronic Urticaria: New Insights and Promising Targets for a Challenging Disease, PMID: 32603278

Tailored therapy for severe asthma, PMID: 25671117

New biologics in the treatment of urticaria, PMID: 30015639

A Better IgE Trap to Control Urticaria, PMID: 31577881

Looking forward to new targeted treatments for chronic spontaneous urticaria, PMID: 28078079

An Update on Anti-IgE Therapy in Pediatric Respiratory Diseases, PMID: 29290750

Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies, PMID: 31836406

Emerging Biomarkers and Therapeutic Pipelines for Chronic Spontaneous Urticaria, PMID: 30033912

Anti-IgE for the Treatment of Chronic Urticaria, PMID: 33628747

Evaluation of Pharmacologic Treatments for H1 Antihistamine-Refractory Chronic Spontaneous Urticaria: A Systematic Review and Network Meta-analysis, PMID: 34431983

Advances in asthma in 2016: Designing individualized approaches to management, PMID: 28709967

The Intersection of IgE Autoantibodies and Eosinophilia in the Pathogenesis of Bullous Pemphigoid, PMID: 31636640

The use of biologics in food allergy, PMID: 33966304

Biologics for the Use in Chronic Spontaneous Urticaria: When and Which, PMID: 33685605

A Comprehensive Approach to Urticaria: From Clinical Presentation to Modern Biological Treatments Through Pathogenesis, PMID: 33385176

Quantitative in vitro and in vivo models to assess human IgE B cell receptor crosslinking by IgE and EMPD IgE targeting antibodies, PMID: 28647457

Management of Pediatric Chronic Spontaneous Urticaria: A Review of Current Evidence and Guidelines, PMID: 33727832

Structural and Functional Insights Into IgE Receptor Interactions and Disruptive Inhibition., PMID:40305523

Efficacy and Safety of Ligelizumab in Chronic Spontaneous Urticaria: A Systematic Review and Meta-analysis of Randomized Controlled Trials., PMID:40186041

Emerging treatments for dermatologic diseases in infants, children, and adolescents: a systematic review of clinical trials on biologics and small molecule inhibitors., PMID:40042725

From wheal to wellness: efficacy and safety of ligelizumab in chronic spontaneous urticaria: a systematic review and meta-analysis., PMID:40014098

Long term safety and efficacy of ligelizumab in the treatment of Japanese patients with chronic spontaneous urticaria., PMID:39327219

Time-course and dose-effect of omalizumab in treating chronic idiopathic urticaria/chronic spontaneous urticaria., PMID:38967658

Biologic therapy for chronic spontaneous urticaria in pediatrics and adolescents: current landscape, challenges, and future perspectives., PMID:38733124

New biologics for food allergy., PMID:38547423

Role of biologics in severe food allergy., PMID:38538153

Efficacy and safety of ligelizumab in adults and adolescents with chronic spontaneous urticaria: results of two phase 3 randomised controlled trials., PMID:38008109

Comparative efficacy of ligelizumab versus omalizumab in chronic spontaneous urticaria., PMID:38008108

Comprehensive Assessment of Pharmacokinetics, Pharmacodynamics, and Tolerability of Ligelizumab in Healthy Volunteers and Patients with Chronic Spontaneous Urticaria to Optimize Its Subcutaneous Delivery System., PMID:37765235

Autoreactive IgE: Pathogenic role and therapeutic target in autoimmune diseases., PMID:37555488

Biologics to treat anaphylaxis., PMID:37527059

Ligelizumab in adolescents with chronic spontaneous urticaria: Results of a dedicated phase 2b randomized clinical trial supported with pharmacometric analysis., PMID:37492920

Why a Complete Response Is the Treatment Aim in Chronic Spontaneous Urticaria., PMID:37240667

Anti-immunoglobulin E for food allergy., PMID:37031775

IgE Depletion with Ligelizumab Does Not Significantly Improve Clinical Symptoms in Patients with Moderate-to-Severe Atopic Dermatitis., PMID:37004878

Impact of Penicillin Allergy Label on Clinical Outcomes of Pneumonia in Children., PMID:36948494

Mapping knowledge structure and research of the biologic treatment of asthma: A bibliometric study., PMID:36845128

Successful ligelizumab treatment of severe refractory solar urticaria., PMID:36796509

Current and future management of chronic spontaneous urticaria and chronic inducible urticaria., PMID:36719690

Ligelizumab improves angioedema, disease severity and quality-of-life in patients with chronic spontaneous urticaria., PMID:36440464

Ligelizumab impairs IgE-binding to plasmacytoid dendritic cells more potently than omalizumab and restores IFN-α production and FOXP3+ Treg generation., PMID:36315052

The rationale for development of ligelizumab in food allergy., PMID:36185545

Penicillin Allergy Label Is Associated With Worse Clinical Outcomes in Bacterial Pneumonia., PMID:36182647

A case of chronic spontaneous urticaria unresponsive to ligelizumab successfully treated with omalizumab., PMID:36164841

Pathophysiology, Diagnosis, and Management of Chronic Spontaneous Urticaria: A Literature Review., PMID:36048326

Identification of mast cell progenitor cells in the airways of individuals with allergic asthma., PMID:36038252

Racial and ethnic disparities in biologic prescriptions for asthma in the United States., PMID:35995400

Hesitancy and reactogenicity to mRNA-based COVID-19 vaccines-Early experience with vaccine rollout in a multi-site healthcare system., PMID:35930586

IgE-neutralizing UB-221 mAb, distinct from omalizumab and ligelizumab, exhibits CD23-mediated IgE downregulation and relieves urticaria symptoms., PMID:35912861

Nodular Skin Lesions in a Patient With X-Linked Agammaglobulinemia., PMID:35790498

Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies., PMID:35744079

Autoimmune chronic spontaneous urticaria., PMID:35667749

Ligelizumab improves sleep interference and disease burden in patients with chronic spontaneous urticaria., PMID:35218324

Emerging treatments for chronic urticaria., PMID:35166638

[Dermatology - Latest developments in targeted therapies for atopic dermatitis, alopecia areata and chronic spontaneous urticaria]., PMID:35107888

Bispecific T-Cell Engagers Targeting Membrane-Bound IgE., PMID:34829798

Sustained safety and efficacy of ligelizumab in patients with chronic spontaneous urticaria: A one-year extension study., PMID:34773261

Impact of Pharmacological Treatments for Chronic Spontaneous Urticaria with an Inadequate Response to H1-Antihistamines on Health-Related Quality of Life: A Systematic Review and Network Meta-Analysis., PMID:34695599

Evaluation of Pharmacologic Treatments for H1 Antihistamine-Refractory Chronic Spontaneous Urticaria: A Systematic Review and Network Meta-analysis., PMID:34431983

The use of biologics in food allergy., PMID:33966304

Ligelizumab treatment for severe asthma: learnings from the clinical development programme., PMID:33747510

Management of Pediatric Chronic Spontaneous Urticaria: A Review of Current Evidence and Guidelines., PMID:33727832

Using National Registries to Identify Targeted Therapies for Refractory Urticaria., PMID:33690233

Biologics for the Use in Chronic Spontaneous Urticaria: When and Which., PMID:33685605

Anti-IgE for the Treatment of Chronic Urticaria., PMID:33628747

Antibodies to watch in 2021., PMID:33459118

A Comprehensive Approach to Urticaria: From Clinical Presentation to Modern Biological Treatments Through Pathogenesis., PMID:33385176

Datasheet

Document Download

Research Grade Ligelizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Ligelizumab [DHJ92702]
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