Catalog No.
YHE73901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro375-Lys609
Predicted molecular weight
53.69 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49959
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HNGS1, Double-strand break repair protein MRE11, MRE11A, Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog A, MRE11 homolog A, MRE11 homolog 1, MRE11, Meiotic recombination 11 homolog 1
FOXD3 promotes homologous recombination repair and genomic stability by facilitating MRE11-mediated DNA end resection., PMID:40515531
Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets., PMID:40484921
Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1., PMID:40479710
FGFR3-induced Y158 PARP1 phosphorylation promotes PARP-inhibitor resistance via BRG1/MRE11-mediated DNA repair in breast cancer models., PMID:40460005
Investigation of a germline variant of uncertain significance (MRE11:c.1138C > T) identified by exome sequencing in a cancer-affected individual and co-segregation analysis in affected and unaffected family members., PMID:40448789
Skin Fibroblasts from Individuals Self-Diagnosed as Electrosensitive Reveal Two Distinct Subsets with Delayed Nucleoshuttling of the ATM Protein in Common., PMID:40429933
Increased DNA damage/repair response in placentas from women infected with COVID-19 in pregnancy., PMID:40393216
PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling., PMID:40387816
Inherited deficiency of DIAPH1 identifies a DNA double strand break repair pathway regulated by γ-actin., PMID:40368919
Targeting DNA damage sensors for cancer therapy., PMID:40339280
Bcl-xL is important for the antiapoptotic activity of Gfi1 and is upregulated by Gfi1 through hemgn., PMID:40262274
NBS1 from Physcomitrium patens confers resistance against oxidative stress through the BRCA1 C-terminus (BRCT) domain, independent of the MRE11 interaction., PMID:40250013
ATM priming and end resection-coupled phosphorylation of MRE11 is important for fork protection and replication restart., PMID:40249789
Mouse MRE11-RAD50-NBS1 is needed to start and extend meiotic DNA end resection., PMID:40240347
Adolescent cetylpyridinium chloride exposure impairs homologous recombination repair and induces granulosa cell apoptosis and follicular atresia via FOXM1/CREBBP complex suppression., PMID:40239548
Gap resection matters in BRCA mutant cancer., PMID:40210436
Comprehensive structural and functional analyses of RAD50 nsSNPs: from prediction to impact assessment., PMID:40206634
Role of MRE11 in DNA damage repair pathway dynamics and its diagnostic and prognostic significance in hereditary breast and ovarian cancer., PMID:40205351
SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression., PMID:40181846
Dynamic conformations of the P. furiosus MR-DNA complex link Mre11 nuclease activity to DNA-stimulated Rad50 ATP hydrolysis., PMID:40175510
MRN-CtIP, EXO1, and DNA2-WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage., PMID:40127955
P21-Activated Kinase 1 (PAK1) Modulates Therapeutic Response to Ionizing Radiation in Head and Neck Squamous Cell Carcinoma Cells., PMID:40099538
Germline variants in CDKN2A wild-type melanoma prone families., PMID:40072281
NBS1 facilitates preribosomal RNA biogenesis., PMID:40067889
Detection of Microsatellite Instability in Endometrial Carcinoma Using a Novel Homopolymer Assay., PMID:40033864
PLK1 phosphorylates WRN at replication forks., PMID:40023583
Phosphorylated BLM peptide acts as an agonist for DNA damage response., PMID:39997217
Oxidative damage to DNA, expression of Mt-1, and activation of repair mechanisms induced by vanadium trioxide in cultures of human lymphocytes., PMID:39897397
Replication-Poison Treatment in BRCA1-Deficient Breast Cancer Causes MRE11 Over-Resection That Induces Single-Stranded DNA Accumulation and Mitotic Catastrophe., PMID:39879120
Transcription near arrested DNA replication forks triggers ribosomal DNA copy number changes., PMID:39876709
Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure., PMID:39870632
In and out of Replication Stress: PCNA/RPA1-Based Dynamics of Fork Stalling and Restart in the Same Cell., PMID:39859385
Novel mutations found in genes involved in global developmental delay and intellectual disability by whole-exome sequencing, homology modeling, and systems biology., PMID:39853208
Discovery of new inhibitors of nuclease MRE11., PMID:39793442
Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its minichromosome., PMID:39752632
NSUN2-mediated R-loop stabilization as a key driver of bladder cancer progression and cisplatin sensitivity., PMID:39732321
Structure guided functional analysis of the S. cerevisiae Mre11 complex., PMID:39711558
MRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses., PMID:39705374
Interaction of DDB1 with NBS1 in a DNA Damage Checkpoint Pathway., PMID:39684807
PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress., PMID:39671289
Phosphorylation of 'SDT-like' motifs in ATRX mediates its interaction with the MRN complex and is important for ALT pathway suppression., PMID:39657822
Ustilago maydis Trf2 ensures genome stability by antagonizing Blm-mediated telomere recombination: Fine-tuning DNA repair factor activity at telomeres through opposing regulations., PMID:39652599
Two-ended recombination at a Flp-nickase-broken replication fork., PMID:39631396
Repair of replication-dependent double-strand breaks differs between the leading and lagging strands., PMID:39631395
Saccharomyces cerevisiae Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50's ATPase activities and homologous recombination., PMID:39630591
CRISPR/Cas9-induced double-strand breaks in the huntingtin locus lead to CAG repeat contraction through DNA end resection and homology-mediated repair., PMID:39627841
The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5., PMID:39615799
Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30., PMID:39613969
STK39-mediated amplification of γ-H2A.X promotes homologous recombination and contributes to PARP inhibitor resistance., PMID:39588777
Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema., PMID:39578839
For research use only. Not for human or drug use.
