Catalog No.
YHE72001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln115-Leu409
Predicted molecular weight
60.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49840
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinase GSK3A
The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance., PMID:40424469
Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development., PMID:39994764
Nicotinamide dual treatment enhances morula-to-blastocyst transition through binding to Zonula Occludens-1 protein., PMID:39987859
Comparative RNA-Seq analysis of differentially expressed genes in the sertoli cells of yak and cattle-yak., PMID:39987073
The Abnormal ERα-miRNA Cross-Talk in AD-Affected Human Hippocampus: A Bioinformatics Perspective., PMID:39966328
Citrulline Inhibits Clostridioides difficile Infection With Anti-inflammatory Effects., PMID:39923847
QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age-related macular degeneration., PMID:39428594
O-GlcNAcylation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, and endoplasmic reticulum., PMID:39405562
Altered hepatic metabolic landscape and insulin sensitivity in response to pulmonary tuberculosis., PMID:39331683
DVL/GSK3/ISL1 pathway signaling: unraveling the mechanism of SIRT3 in neurogenesis and AD therapy., PMID:39267160
Targeting Gsk3a reverses immune evasion to enhance immunotherapy in hepatocellular carcinoma., PMID:39174053
GSK3: A potential target and pending issues for treatment of Alzheimer's disease., PMID:38946682
CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice., PMID:38597936
Quantitative phosphoproteomics explain cryopreservation-induced reductions in ram sperm motility., PMID:38438079
The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of β-catenin stability., PMID:38410441
CETSA-MS-based target profiling of anti-aging natural compound quercetin., PMID:38342014
Differential role of bovine serum albumin and HCO3- in the regulation of GSK3 alpha during mouse sperm capacitation., PMID:38341666
New insights into the role of GSK-3β in the brain: from neurodegenerative disease to tumorigenesis., PMID:38107562
Ultrarare Missense Variants Implicated in Utah Pedigrees Multiply Affected With Schizophrenia., PMID:37881554
High-throughput Oligopaint screen identifies druggable 3D genome regulators., PMID:37438531
Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells., PMID:37201366
Distribution of Exonic Variants in Glycogen Synthesis and Catabolism Genes in Late Onset Pompe Disease (LOPD)., PMID:37185710
Deciphering the Clinical Significance and Kinase Functions of GSK3α in Colon Cancer by Proteomics and Phosphoproteomics., PMID:37031867
Machine learning-based predictive models and drug prediction for schizophrenia in multiple programmed cell death patterns., PMID:36993785
Active Ingredient Paeonol of Jijiu Huiyang Decoction Alleviates Isoproterenol-Induced Chronic Heart Failure via the GSK3A/PPARα Pathway., PMID:36785789
Identification of immune- and autophagy-related genes and effective diagnostic biomarkers in endometriosis: a bioinformatics analysis., PMID:36660690
The non-invasive diagnosis of colorectal cancer via a SOX9-based gene panel., PMID:36637582
Environmental concentrations of benzophenone-3 disturbed lipid metabolism in the liver of clown anemonefish (Amphiprion ocellaris)., PMID:36473638
Specific Role for GSK3α in Limiting Long-Term Potentiation in CA1 Pyramidal Neurons of Adult Mouse Hippocampus., PMID:35782378
Effects of heroin self-administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats., PMID:35467104
SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load., PMID:35105893
Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin., PMID:34788728
Inhibition of T-antigen expression promoting glycogen synthase kinase 3 impairs merkel cell carcinoma cell growth., PMID:34715251
Quantitative phosphoproteomics reveals GSK3A substrate network is involved in the cryodamage of sperm motility., PMID:34596222
Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition., PMID:34593624
Cardiomyocyte-produced miR-339-5p mediates pathology in Duchenne muscular dystrophy cardiomyopathy., PMID:34270708
Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition., PMID:33655282
Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling in mice., PMID:33609145
Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes of Uveitis., PMID:33503442
Evaluation of the Serum Dkk-1, Tenascin-C, Oxidative Stress Markers Levels and Wnt Signaling Pathway Genes Expression in Patients with Alzheimer's Disease., PMID:32935274
GSK3β inhibition restores cortical gamma oscillation and cognitive behavior in a mouse model of NMDA receptor hypofunction relevant to schizophrenia., PMID:32859995
Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice., PMID:32257815
Targeting bioenergetics prevents CD4 T cell-mediated activation of synovial fibroblasts in rheumatoid arthritis., PMID:32047926
Response of canonical Wnt/β-catenin signaling pathway in the intestine to microgravity stress in Caenorhabditis elegans., PMID:31614302
Gene expression profiling of skeletal myogenesis in human embryonic stem cells reveals a potential cascade of transcription factors regulating stages of myogenesis, including quiescent/activated satellite cell-like gene expression., PMID:31560727
GSK-3 modulates SHH-driven proliferation in postnatal cerebellar neurogenesis and medulloblastoma., PMID:31540917
A kinome-wide shRNA screen uncovers vaccinia-related kinase 3 (VRK3) as an essential gene for diffuse intrinsic pontine glioma survival., PMID:31324890
A six-inhibitor culture medium for improving naïve-type pluripotency of porcine pluripotent stem cells., PMID:31240131
Estrogen receptor alpha regulates the Wnt/β-catenin signaling pathway in colon cancer by targeting the NOD-like receptors., PMID:31121307
Phosphoproteomic Profiling Identifies Aberrant Activation of Integrin Signaling in Aggressive Non-Type Bladder Carcinoma., PMID:31108958
For research use only. Not for human or drug use.
