Catalog No.
YHE71501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser38-Ala205
Predicted molecular weight
21.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49798
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RGS4, RGP4, Regulator of G-protein signaling 4
Ailanthone Restrains Osteosarcoma Growth and Metastasis by Decreasing the Expression of Regulator of G Protein Signaling 4 and Twist Family BHLH Transcription Factor 1., PMID:40047202
CircWDR78 inhibits the development of colorectal cancer by regulating the miR-653-3p/RGS4 axis., PMID:39912944
RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition., PMID:39811500
RGS Proteins in Sympathetic Nervous System Regulation: Focus on Adrenal RGS4., PMID:39473413
MEOX1 triggers myofibroblast apoptosis resistance, contributing to pulmonary fibrosis in mice., PMID:39319990
Hsa-miR-874-3p Reduces Endogenous Expression of RGS4-1 Isoform In Vitro., PMID:39202417
Ophiopogonin D' inhibited tumour growth and metastasis of anaplastic thyroid cancer by modulating JUN/RGS4 signalling., PMID:39153211
MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway., PMID:38971310
RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms., PMID:38432633
Oxygen-Sensing Protein Cysteamine Dioxygenase from Mandarin Fish Involved in the Arg/N-Degron Pathway and Siniperca chuatsi Rhabdovirus Infection., PMID:37631990
Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4., PMID:37047106
The roles of ubiquitin-proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure., PMID:36793204
Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling., PMID:35628613
Differential methamphetamine-induced behavioral effects in male and female mice lacking regulator of G Protein signaling 4., PMID:35085702
Attenuation of nicotine-induced rewarding and antidepressant-like effects in male and female mice lacking regulator of G-protein signaling 2., PMID:35038444
RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in Neurons., PMID:34884825
NKX2-1 re-expression induces cell death through apoptosis and necrosis in dedifferentiated thyroid carcinoma cells., PMID:34748583
Mixed-solvent molecular dynamics simulation-based discovery of a putative allosteric site on regulator of G protein signaling 4., PMID:34494289
LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression., PMID:34450404
Impaired regulation of heart rate and sinoatrial node function by the parasympathetic nervous system in type 2 diabetic mice., PMID:34127743
The association between RGS4 and choline in cardiac fibrosis., PMID:33892733
The Antipsychotic Drug Clozapine Suppresses the RGS4 Polyubiquitylation and Proteasomal Degradation Mediated by the Arg/N-Degron Pathway., PMID:33884581
Single Molecule-Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet β-Cells., PMID:33685924
Regulator of G Protein Signalling 4 (RGS4) as a Novel Target for the Treatment of Sensorineural Hearing Loss., PMID:33374915
SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic β cells., PMID:33067534
Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in neurons., PMID:32779957
Regulators of G-protein signaling, RGS2 and RGS4, inhibit protease-activated receptor 4-mediated signaling by forming a complex with the receptor and Gα in live cells., PMID:32517689
RGS4 controls Gαi3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes., PMID:32501280
Targeting RGS4 Ablates Glioblastoma Proliferation., PMID:32392739
miR-874-3p inhibits cell migration through targeting RGS4 in osteosarcoma., PMID:32386256
RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis., PMID:32199913
HuR (Human Antigen R) Regulates the Contraction of Vascular Smooth Muscle and Maintains Blood Pressure., PMID:32075416
RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor., PMID:31695428
TRPM2-AS inhibits the growth, migration, and invasion of gliomas through JNK, c-Jun, and RGS4., PMID:31637708
RGS2 drives male aggression in mice via the serotonergic system., PMID:31633064
lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer., PMID:31587286
An Interhelical Salt Bridge Controls Flexibility and Inhibitor Potency for Regulators of G-protein Signaling Proteins 4, 8, and 19., PMID:31543506
A highly conserved δ-opioid receptor region determines RGS4 interaction., PMID:31386272
MiR-21-3p modulates lipopolysaccharide-induced inflammation and apoptosis via targeting TGS4 in retinal pigment epithelial cells., PMID:31330059
Live cell imaging reveals 3'-UTR dependent mRNA sorting to synapses., PMID:31320644
RGS4 Maintains Chronic Pain Symptoms in Rodent Models., PMID:31308097
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants., PMID:31273118
Regulator of G Protein Signaling 2 Facilitates Uterine Artery Adaptation During Pregnancy in Mice., PMID:31030617
Interplay of cysteine exposure and global protein dynamics in small-molecule recognition by a regulator of G-protein signaling protein., PMID:30521141
RGS4 deficit in prefrontal cortex contributes to the behaviors related to schizophrenia via system xc--mediated glutamatergic dysfunction in mice., PMID:30279737
Interpreting Hydrogen-Deuterium Exchange Events in Proteins Using Atomistic Simulations: Case Studies on Regulators of G-Protein Signaling Proteins., PMID:30222348
Regulators of G-protein signaling 2 and 4 differentially regulate cocaine-induced rewarding effects., PMID:30036561
PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model., PMID:30022363
Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity., PMID:29955167
Regulator of G-Protein Signaling 4 (RGS4) Controls Morphine Reward by Glutamate Receptor Activation in the Nucleus Accumbens of Mouse Brain., PMID:29754475
For research use only. Not for human or drug use.
