Catalog No.
YHE68801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe657-Phe904
Predicted molecular weight
31.33 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49736
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CCNL1, KIAA0030, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28, MCM2, CDCL1, BM28, DNA replication licensing factor MCM2
Immunohistological localization of MDM2, MCM2, Fascin, PCNA, EGFR in paraffin section; in the normal and cancerous human ovary., PMID:40315767
Thymopoietin-α, -β, and -γ Isoforms Increased Expression in Cervical Cancer Cells., PMID:40242184
Refining prognostic stratification of atypical meningiomas: significance of chromosome 1p deletion and brain invasion., PMID:40050905
Unidirectional MCM translocation away from ORC drives origin licensing., PMID:39824870
Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates., PMID:39779677
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis., PMID:39747125
ANXA4 restricts HBV replication by inhibiting autophagic degradation of MCM2 in chronic hepatitis B., PMID:39511535
Molecular mechanism of parental H3/H4 recycling at a replication fork., PMID:39488545
Evaluation of BUBR1, MCM2, and GMNN as oral cancer biomarkers., PMID:39480819
Integrating Mcm-2 and Ki-67 immunohistochemistry with clinico-pathologic parameters for enhanced prognostic accuracy in oral verrucous lesions., PMID:39244032
Identification of prevention marker associated with DNA replication in ovarian cancer: Expression of MCM2 protein and bioinformatics analysis., PMID:39187104
Targeting MCM2 activates cancer-associated fibroblasts-like phenotype and affects chemo-resistance of liposarcoma cells against doxorubicin., PMID:39109389
In vitro observation of histone-hexamer association with and dissociation from the amino-terminal region of budding yeast Mcm2, a subunit of the replicative helicase., PMID:39103894
Pixantrone as a novel MCM2 inhibitor for ovarian cancer treatment., PMID:39032764
RUNX1 regulates MCM2/CDC20 to promote COAD progression modified by deubiquitination of USP31., PMID:38886545
KNTC1 knockdown inhibits the proliferation and migration of osteosarcoma cells by MCM2., PMID:38818892
DNA polymerase delta governs parental histone transfer to DNA replication lagging strand., PMID:38713623
DNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains., PMID:38600242
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2., PMID:38478295
Regulation of cancer stem cells by CXCL1, a chemokine whose secretion is controlled by MCM2., PMID:38454443
Parental histone transfer caught at the replication fork., PMID:38448592
MCM2 is involved in subtyping and tamoxifen resistance of ERα-positive breast cancer by acting as the downstream factor of ERα., PMID:38403459
Role of Serine arginine protein kinase 1 and Minichromosome maintenance protein 2 in predicting epithelial ovarian cancer response to treatment and prognosis., PMID:38216547
MCM2 promotes the stemness of endometrial cancer cells via the Akt/β-catenin pathway., PMID:38053378
Coiled-coil domain-containing 154 promotes colorectal cancer proliferation and metastasis via interacting with minichromosome maintenance complex component 2., PMID:37863352
Validating MCM2 as a clinically relevant surrogate immunohistochemical marker for an aggressive meningioma molecular subtype., PMID:37837323
Characterization of histone chaperone MCM2 as a key regulator in arsenic-induced depletion of H3.3 at genomic loci., PMID:37734572
KNTC1 and MCM2 are the molecular targets of gallbladder cancer., PMID:37480569
Circ_0104700 contributes to acute myeloid leukemia progression by enhancing MCM2 expression through targeting miR-665., PMID:37358551
Calcyclin-binding protein contributes to cholangiocarcinoma progression by inhibiting ubiquitination of MCM2., PMID:37305391
RAD51 bypasses the CMG helicase to promote replication fork reversal., PMID:37104614
Expression of Minichromosome Maintenance Protein 2 (MCM2) in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: A Systematic Review., PMID:37007886
The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress., PMID:36807739
ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway., PMID:36778110
Hypoxia Inhibits Cell Cycle Progression and Cell Proliferation in Brain Microvascular Endothelial Cells via the miR-212-3p/MCM2 Axis., PMID:36769104
MCM2 in human cancer: functions, mechanisms, and clinical significance., PMID:36303105
Different expression of DNMT1, PCNA, MCM2, CDT1, EZH2, GMNN and EP300 genes in lymphomagenesis of low vs. high grade lymphoma., PMID:36257233
Comparative evaluation of immunohistochemical expression of MCM2 and Ki67 in oral epithelial dysplasia and oral squamous cell carcinoma., PMID:36149152
Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context., PMID:35920299
WASHC1 interacts with MCM2-7 complex to promote cell survival under replication stress., PMID:35733063
Mechanism of replication origin melting nucleated by CMG helicase assembly., PMID:35705812
ITRAQ-based quantitative proteomic analysis reveals that VPS35 promotes the expression of MCM2-7 genes in HeLa cells., PMID:35690672
The Minichromosome Maintenance Complex Component 2 (MjMCM2) of Meloidogyne javanica is a potential effector regulating the cell cycle in nematode-induced galls., PMID:35654810
MCM2 mutation causes autosomal dominant nonsyndromic hearing loss (DFNA70): novel variant in the second family., PMID:35652205
The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer., PMID:35614055
Expression of MCM2 as a Proliferative Marker in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma., PMID:35478139
MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells., PMID:35438632
MCM2 promotes the proliferation, migration and invasion of cholangiocarcinoma cells by reducing the p53 signaling pathway., PMID:35307646
Demethylation at enhancer upregulates MCM2 and NUP37 expression predicting poor survival in hepatocellular carcinoma patients., PMID:35093119
Thiabendazole Inhibits Glioblastoma Cell Proliferation and Invasion Targeting Mini-chromosome Maintenance Protein 2., PMID:34750208
For research use only. Not for human or drug use.
