Catalog No.
YHE65401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln539
Predicted molecular weight
60.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49419
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ALDH7A1, Delta1-piperideine-6-carboxylate dehydrogenase, Antiquitin-1, P6c dehydrogenase, Alpha-AASA dehydrogenase, Alpha-aminoadipic semialdehyde dehydrogenase, Aldehyde dehydrogenase family 7 member A1, Betaine aldehyde dehydrogenase, ATQ1
Cell death: Dynamics and compartmentalization of NADH and FSP1 in ferroptosis., PMID:40494283
Towards a kingdom of reproductive life - the core sperm proteome., PMID:40298292
ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1., PMID:40233740
Neonatal/infantile-onset genetic epilepsies: The utility of genetic testing for molecular etiology-specific diagnosis concerning therapeutic implications., PMID:40072314
Dysregulation of astrocyte-derived matrix gla protein impairs dendritic spine development in pyridoxine-dependent epilepsy., PMID:39980193
Feasibility of newborn screening for pyridoxine-dependent epilepsy., PMID:39729892
ALDH Enzymes and Hematological Diseases: A Scoping Review of Literature., PMID:39726306
Identification of ALDH7A1 as a DNA-methylation-driven gene in lung squamous cell carcinoma., PMID:39711312
Restricting lysine normalizes toxic catabolites associated with ALDH7A1 deficiency in cells and mice., PMID:39661514
Pyridoxine-dependent epilepsy caused by an ALDH7A1 mutation in an infant girl: the first case report in Syria., PMID:39501195
[Phenotype of infantile epileptic spasm syndrome in pyridoxin-dependent epilepsy]., PMID:39397454
ALDH and cancer stem cells: Pathways, challenges, and future directions in targeted therapy., PMID:39222837
Assessment of urinary 6-oxo-pipecolic acid as a biomarker for ALDH7A1 deficiency., PMID:39038845
Characterization of 13 Novel Genetic Variants in Genes Associated with Epilepsy: Implications for Targeted Therapeutic Strategies., PMID:39003674
Generation of hiPSC lines from four pyridoxine-dependent epilepsy (PDE) patients carrying the variant c.1279G>C in ALDH7A1 in homozygosis., PMID:38936157
A rare case of pyridoxine-dependent epilepsy with novel ALDH7A1 mutation., PMID:38724351
Single-nucleus transcriptomics and chromatin accessibility analysis of musk gland development in Chinese forest musk deer (Moschus berezovskii)., PMID:38644525
Genotype and phenotype features and prognostic factors of neonatal-onset pyridoxine-dependent epilepsy: A systematic review., PMID:38636407
Biochemical, structural, and computational analyses of two new clinically identified missense mutations of ALDH7A1., PMID:38604394
Molecular strategies of the pygmy grasshopper Eucriotettix oculatus adapting to long-term heavy metal pollution., PMID:38599159
Transcriptomic insights into multiple system atrophy from a PLP-α-synuclein transgenic mouse model., PMID:38575106
Importance of targeted next-generation sequencing in pediatric patients with developmental epileptic encephalopathy., PMID:37820178
Landscape of genetic infantile epileptic spasms syndrome-A multicenter cohort of 124 children from India., PMID:37583270
Generation of an induced pluripotent stem cell line carrying biallelic deletions (SCTCi019-B) in ALDH7A1 using CRISPR/Cas9., PMID:37540965
On pathways and blind alleys-The importance of biomarkers in vitamin B6 -dependent epilepsies., PMID:37428623
Genomic analysis of multiplex consanguineous families reveals causes of neurodevelopmental disorders with epilepsy., PMID:37393059
METTL3-mediated ALDH m6A methylation regulates the malignant behavior of BMI1+ HNSCC stem cells., PMID:37249063
Perspectives of Rare Disease Experts on Newborn Genome Sequencing., PMID:37155167
Epilepsy Phenotypes of Vitamin B6-Dependent Diseases: An Updated Systematic Review., PMID:36980111
Brain-wide transcriptome-based metabolic alterations in Parkinson's disease: human inter-region and human-experimental model correlations., PMID:36928892
Global Metabolomics Discovers Two Novel Biomarkers in Pyridoxine-Dependent Epilepsy Caused by ALDH7A1 Deficiency., PMID:36555701
Highly effective identification of drug targets at the proteome level by pH-dependent protein precipitation., PMID:36382280
Pyridoxine-dependent Epilepsy caused by a Novel homozygous mutation in PLPBP Gene., PMID:36308585
Identification of lncRNAs Associated with the Pathogenesis of Diabetic Retinopathy: From Sequencing Analysis to Validation via In Vivo and In Vitro Experiments., PMID:36299680
A Comparison of RNA Interference via Injection and Feeding in Honey Bees., PMID:36292876
Transcriptome and genome sequencing investigating the molecular characteristics of patients with varicocele infertility., PMID:35922383
Analysis of clinical phenotypic and genotypic spectra in 36 children patients with Epilepsy of Infancy with Migrating Focal Seizures., PMID:35715422
The impact of ALDH7A1 variants in oral cancer development and prognosis., PMID:35613852
An Atlas of the Quantitative Protein Expression of Anti-Epileptic-Drug Transporters, Metabolizing Enzymes and Tight Junctions at the Blood-Brain Barrier in Epileptic Patients., PMID:34959403
Is impaired energy production a novel insight into the pathogenesis of pyridoxine-dependent epilepsy due to biallelic variants in ALDH7A1?, PMID:34495967
EPS8 supports pancreatic cancer growth by inhibiting BMI1 mediated proteasomal degradation of ALDH7A1., PMID:34391775
A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis., PMID:34186243
Cognitive and neurological outcome of patients in the Dutch pyridoxine-dependent epilepsy (PDE-ALDH7A1) cohort, a cross-sectional study., PMID:34153871
Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy., PMID:34138754
A glycolysis-based three-gene signature predicts survival in patients with lung squamous cell carcinoma., PMID:34044809
Identification of a glycolysis-related gene signature associated with clinical outcome for patients with lung squamous cell carcinoma., PMID:33991070
[Genotype and phenotype analysis of neonates with neonatal encephalopathy complicated with perinatal hypoxic event]., PMID:33775046
Administration of a recombinant ALDH7A1 (rA7) indicates potential regulation of the metabolite and immunology pathways in Atlantic salmon infected with Aeromonas salmonicida., PMID:33645734
Overall survival of pancreatic ductal adenocarcinoma is doubled by Aldh7a1 deletion in the KPC mouse., PMID:33537098
Inherited Disorders of Lysine Metabolism: A Review., PMID:33000154
For research use only. Not for human or drug use.
