Catalog No.
YHE62701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu139-Tyr367
Predicted molecular weight
28.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49137
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAPKAPK2, MAPKAP-K2, MAPKAP kinase 2, MAPKAPK-2, MAP kinase-activated protein kinase 2, MK2, MK-2, MAPK-activated protein kinase 2
Polymorphisms in Necroptosis Pathway Genes: Novel Prognostic Markers for Multiple Myeloma Treatment Outcomes., PMID:40508046
Interferon regulatory factor 8 induces intrinsic functional changes in mature neutrophils., PMID:40457627
Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells., PMID:40439108
Based on the Dual Pathway of Interaction-Mediated NF-κB in Cell Apoptosis and Immune Inflammation to Study the Effect of Danzhi Xiaoyao Powder on the Learning and Cognitive Ability of AD Model Rats., PMID:40297714
COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma., PMID:40198582
MK2 promotes p16 negative head and neck cancer migration, invasion, and metastasis., PMID:40185303
Evaluation of Pyrrolone-Fused Benzosuberene MK2 Inhibitors as Promising Therapeutic Agents for HNSCC: In Vitro Efficacy, In-Vivo Safety, and Pharmacokinetic Profiling., PMID:40009048
Qing-Xin-Jie-Yu Granule attenuates myocardial infarction-induced inflammatory response by regulating the MK2/TTP pathway., PMID:39980416
Potential drug targets for ovarian cancer identified through Mendelian randomization and colocalization analysis., PMID:39972314
MK2 Inhibition in CD4+ T Cells Protects Against IFNγ and IL-17A, Chronic Inflammation, and Fibrosis in Inflammatory Bowel Disease Models., PMID:39937137
Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma., PMID:39805854
Human miR-1 Stimulates Metabolic and Thermogenic-Related Genes in Adipocytes., PMID:39796132
Discovery of a Novel p38α-MK2 Complex Inhibitor as a Potential Choice for Autoimmune Diseases., PMID:39783259
Loss of MK2 Enhances Radiation-Mediated Apoptosis in Bladder Cancer., PMID:39697425
Shiga Toxins Produced by Enterohaemorrhagic Escherichia coli Induce Inflammation in Toxin-Sensitive Cells through the p38 MAPK/MK2/Tristetraprolin Signaling Pathway., PMID:39617691
Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer's disease., PMID:39610246
Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27., PMID:39541976
Novel pyrrolone-fused benzosuberene MK2 inhibitors: synthesis, pharmacophore modelling, molecular docking, and anti-cancer efficacy evaluation in HNSCC cells., PMID:39540409
Mode of action exploration for prostate epithelial cell injury caused by bisphenol A., PMID:39442252
Therapeutic targets for gastrointestinal diseases: proteome-wide Mendelian randomization and colocalization analyses., PMID:39400547
MiR-509-3p promotes gastric cancer development by activating FOXM1-mediated p38/MK2 pathway., PMID:39319839
Long non-coding RNA MAGEA4-AS1 binding to p53 enhances MK2 signaling pathway and promotes the proliferation and metastasis of oral squamous cell carcinoma., PMID:39249547
Intravascular delivery of an MK2 inhibitory peptide to prevent restenosis after angioplasty., PMID:39216327
Regulation of Zfp36 by ISGF3 and MK2 restricts the expression of inflammatory cytokines during necroptosis stimulation., PMID:39117638
Decreased expression of DRA (SLC26A3) by a p38-driven IL-1α response contributes to diarrheal disease following in vivo challenge with Brachyspira spp., PMID:39104321
Hydroxychloroquine attenuates double-stranded RNA-stimulated hyper-phosphorylation of tristetraprolin/ZFP36 and AU-rich mRNA stabilization., PMID:39046234
MK2 inhibitor PF-3644022 shows protective effect in mouse microglial N9 cell line induced with cigarette smoke extract., PMID:39013758
Expression profile of mRNAs and miRNAs related to mitogen-activated kinases in HaCaT cell culture treated with lipopolysaccharide a and adalimumab., PMID:38557266
Interrogating endothelial barrier regulation by temporally resolved kinase network generation., PMID:38467420
MAPK-activated protein kinase 2 is associated with poor prognosis of glioma patients and immune inhibition in glioma., PMID:38322416
Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy., PMID:38250706
Increased Activity of MAPKAPK2 within Mesenchymal Cells as a Target for Inflammation-Associated Fibrosis in Crohn's Disease., PMID:38224550
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation., PMID:38041016
Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-β signaling feedback loop., PMID:37935976
Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency., PMID:37775760
Identification of co-diagnostic effect genes for aortic dissection and metabolic syndrome by multiple machine learning algorithms., PMID:37684281
PME-1 sensitizes glioblastoma cells to oxidative stress-induced cell death by attenuating PP2A-B55α-mediated inactivation of MAPKAPK2-RIPK1 signaling., PMID:37500619
MK2 drives progression of pancreas and colon cancers by suppressing CD8+ T cell cytotoxic function and is a potential immunotherapy target., PMID:37415974
The evolving landscape of involvement of DTYMK enzymes in cancer., PMID:37358701
Repeated Rounds of Gonadotropin Stimulation Induce Imbalance in the Antioxidant Machinery and Activation of Pro-Survival Proteins in Mouse Oviducts., PMID:37298244
CD93 Ameliorates Diabetic Wounds by Promoting Angiogenesis via the p38MAPK/MK2/HSP27 Axis., PMID:37295599
Self-delivering mRNA inhibitors of MK2 improve outcomes after spinal cord injury., PMID:37172370
DNA-PKcs as an upstream mediator of OCT4-induced MYC activation in small cell lung cancer., PMID:37116859
Comprehensive analysis of arachidonic acid metabolism-related genes in diagnosis and synovial immune in osteoarthritis: based on bulk and single-cell RNA sequencing data., PMID:36995411
MK2 nonenzymatically promotes nuclear translocation of caspase-3 and resultant apoptosis., PMID:36976920
Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer., PMID:36878491
MAPKAPK2-centric transcriptome profiling reveals its major role in governing molecular crosstalk of IGFBP2, MUC4, and PRKAR2B during HNSCC pathogenesis., PMID:36817960
Early response evaluation by single cell signaling profiling in acute myeloid leukemia., PMID:36611026
MK2 Inhibitors as a Potential Crohn's Disease Treatment Approach for Regulating MMP Expression, Cleavage of Checkpoint Molecules and T Cell Activity., PMID:36558958
Umifenovir Epigenetically Targets the IL-10 Pathway in Therapy against Coxsackievirus B4 Infection., PMID:36541788
For research use only. Not for human or drug use.
