Catalog No.
YHE62601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg191-Pro503
Predicted molecular weight
36.44 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49116
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, TAK1, Nuclear receptor subfamily 2 group C member 2, TR4, NR2C2, Testicular receptor 4
TR4 and BCL11A repress γ-globin transcription via independent mechanisms., PMID:39393056
Roles of Nuclear Orphan Receptors TR2 and TR4 during Hematopoiesis., PMID:38790192
TR4 worsen urosepsis by regulating GSDMD., PMID:38429762
Regulation of the stem‑like properties of estrogen receptor‑positive breast cancer cells through NR2E3/NR2C2 signaling., PMID:37664670
The Diagnostic Features of Peripheral Blood Biomarkers in Identifying Osteoarthritis Individuals: Machine Learning Strategies and Clinical Evidence., PMID:37594094
NR2C2 of macrophages promotes inflammation via NF-κB in LPS-induced orchitis in mice., PMID:37427695
Propionate regulates tight junction barrier by increasing endothelial-cell selective adhesion molecule in human intestinal Caco-2 cells., PMID:36842619
Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation., PMID:36651297
Gonadal hormone trigger the dynamic microglial alterations through Traf6/TAK1 axis that correlate with depressive behaviors., PMID:35724494
Orphan nuclear receptors in angiogenesis and follicular development., PMID:34270446
Several Fusion Genes Identified in a Spermatic Cord Leiomyoma With Rearrangements of Chromosome Arms 3p and 21q., PMID:34183386
The Chromatin Accessibility Landscape of Peripheral Blood Mononuclear Cells in Patients With Systemic Lupus Erythematosus at Single-Cell Resolution., PMID:34084162
Use of miR‑145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer., PMID:33650661
The PARP Inhibitor Olaparib Modulates the Transcriptional Regulatory Networks of Long Non-Coding RNAs during Vasculogenic Mimicry., PMID:33333852
The absence of (TCAGGG)n repeats in some telomeres, combined with variable responses to NR2F2 depletion, suggest that this nuclear receptor plays an indirect role in the alternative lengthening of telomeres., PMID:33244044
Targeting the radiation-induced TR4 nuclear receptor-mediated QKI/circZEB1/miR-141-3p/ZEB1 signaling increases prostate cancer radiosensitivity., PMID:32768524
Chemically Induced Hypoxia Enhances miRNA Functions in Breast Cancer., PMID:32707933
The plasma peptides of breast versus ovarian cancer., PMID:31889940
Targeting TR4 nuclear receptor with antagonist bexarotene increases docetaxel sensitivity to better suppress the metastatic castration-resistant prostate cancer progression., PMID:31748715
Targeting the TR4 nuclear receptor-mediated lncTASR/AXL signaling with tretinoin increases the sunitinib sensitivity to better suppress the RCC progression., PMID:31501521
Remission clone in acute myeloid leukemia shows growth advantage after chemotherapy but is distinct from leukemic clone., PMID:31199945
Computational identification of tissue-specific transcription factor cooperation in ten cattle tissues., PMID:31095599
Di(2-ethylhexyl)phthalate induces reproductive toxicity via JAZF1/TR4 pathway and oxidative stress in pubertal male rats., PMID:30755103
NR2C2-uORF targeting UCA1-miR-627-5p-NR2C2 feedback loop to regulate the malignant behaviors of glioma cells., PMID:30518750
A novel lncRNA, TCONS_00006195, represses hepatocellular carcinoma progression by inhibiting enzymatic activity of ENO1., PMID:30518748
Role and mechanism of miR-4778-3p and its targets NR2C2 and Med19 in cervical cancer radioresistance., PMID:30473219
BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression., PMID:30463901
Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective., PMID:30020984
New Molecular Targets for Treatment of Cushing's Disease., PMID:29754637
TR4 nuclear receptor suppresses HCC cell invasion via downregulating the EphA2 expression., PMID:29449527
Preclinical studies using miR-32-5p to suppress clear cell renal cell carcinoma metastasis via altering the miR-32-5p/TR4/HGF/Met signaling., PMID:29396852
Testicular orphan receptor 4 promotes tumor progression and implies poor survival through AKT3 regulation in seminoma., PMID:29197138
The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation., PMID:29018082
TLR2, TLR3 and TLR5 regulation of pro-inflammatory and pro-labour mediators in human primary myometrial cells., PMID:28844021
TR2 and TR4 Orphan Nuclear Receptors: An Overview., PMID:28527578
RIP140 in monocytes/macrophages regulates osteoclast differentiation and bone homeostasis., PMID:28405613
False responses of Renilla luciferase reporter control to nuclear receptor TR4., PMID:28210900
OPMSP: A Computational Method Integrating Protein Interaction and Sequence Information for the Identification of Novel Putative Oncogenes., PMID:27774893
Whole-genome expression analysis reveals genes associated with treatment response to escitalopram in major depression., PMID:27461515
TR4 nuclear receptor enhances the cisplatin chemo-sensitivity via altering the ATF3 expression to better suppress HCC cell growth., PMID:27050071
Bioinformatics Analyses of Differentially Expressed Genes Associated with Acute Myocardial Infarction., PMID:26725916
TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGFβR2/p-Smad3 signals., PMID:25980442
The Differential Effects of Anti-Diabetic Thiazolidinedione on Prostate Cancer Progression Are Linked to the TR4 Nuclear Receptor Expression Status., PMID:25925376
TR4 Nuclear Receptor Alters the Prostate Cancer CD133+ Stem/Progenitor Cell Invasion via Modulating the EZH2-Related Metastasis Gene Expression., PMID:25833838
Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals., PMID:25623427
Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes., PMID:25561507
TR4 promotes fatty acid synthesis in 3T3-L1 adipocytes by activation of pyruvate carboxylase expression., PMID:25240193
TR4 nuclear receptor promotes prostate cancer metastasis via upregulation of CCL2/CCR2 signaling., PMID:24975468
Mycobacterium tuberculosis keto-mycolic acid and macrophage nuclear receptor TR4 modulate foamy biogenesis in granulomas: a case of a heterologous and noncanonical ligand-receptor pair., PMID:24907344
SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway., PMID:24703702
For research use only. Not for human or drug use.
