Catalog No.
YHE60601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys130-Phe337
Predicted molecular weight
26.69 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P48729
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CK1, Casein kinase I isoform alpha, CSNK1A1, CKI-alpha
The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance., PMID:40424469
The role of CSNK1A1 and its de novo mutations in infantile spasms syndrome., PMID:40156289
A guide to selecting high-performing antibodies for CSNK1A1 (UniProt ID: P48729) for use in western blot, immunoprecipitation, and immunofluorescence., PMID:40028451
Haploinsufficiency of miR-143 and miR-145 reveal targetable dependencies in resistant del(5q) myelodysplastic neoplasm., PMID:40000845
Multi-modal transcriptomics: integrating machine learning and convolutional neural networks to identify immune biomarkers in atherosclerosis., PMID:39660117
Comparative analysis of differentially expressed genes and transcripts in the ovary of yak in estrus and anestrus., PMID:39558653
Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells., PMID:39183304
The chemical composition and the preservative, antimicrobial, and antioxidant effects of Thymus broussonetii Boiss. essential oil: an in vitro and in silico approach., PMID:39027726
Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation., PMID:38940554
Exploring the role of casein kinase 1α splice variants across cancer cell lines., PMID:38852281
The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of β-catenin stability., PMID:38410441
Modulation of Cullin-RING E3 ubiquitin ligase-dependent ubiquitination by small molecule compounds., PMID:38354780
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines., PMID:38228616
Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation., PMID:38147624
PLK1 Regulates MicroRNA Biogenesis through Drosha Phosphorylation., PMID:37762595
CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling., PMID:37723657
Phosphorylation of axin within biomolecular condensates counteracts its tankyrase-mediated degradation., PMID:37721093
Oncogenic K-Ras suppresses global miRNA function., PMID:37402366
Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression., PMID:37168577
Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex., PMID:37149115
Detection of a Novel MSI2-C17orf64 Transcript in a Patient with Aggressive Adenocarcinoma of the Gastroesophageal Junction: A Case Report., PMID:37107676
Exploring the Associations between Alzheimer's Disease and GBM Mediated by Microglia Based on Network Analysis., PMID:36946454
Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori., PMID:36720664
Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice., PMID:36542875
Comprehensive analysis of dysregulated circular RNAs and construction of a ceRNA network involved in the pathology of Alzheimer's disease in a 5 × FAD mouse model., PMID:36466608
Detection of concentration-dependent conformational changes in SARS-CoV-2 nucleoprotein by agarose native gel electrophoresis., PMID:36427555
Identifying significant genes and functionally enriched pathways in familial hypercholesterolemia using integrated gene co-expression network analysis., PMID:35844366
Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q., PMID:35617825
Defining molecular glues with a dual-nanobody cannabidiol sensor., PMID:35145136
Identification of inflammatory response and alternative splicing in acute kidney injury and experimental verification of the involvement of RNA‑binding protein RBFOX1 in this disease., PMID:35059728
Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216., PMID:34965125
Integrative analysis of lung molecular signatures reveals key drivers of idiopathic pulmonary fibrosis., PMID:34876074
A comparative transcriptome and proteomics study of post-partum ovarian cycle arrest in yaks (Bos grunniens)., PMID:34850471
MCPIP1 inhibits Wnt/β-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs., PMID:34657130
NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly., PMID:34615873
Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma., PMID:34216174
Reversible modulation of circadian time with chronophotopharmacology., PMID:34039965
Targeting Protein Kinases in Blood Cancer: Focusing on CK1α and CK2., PMID:33918307
Reprogramming of erythrocyte lifespan by NFκB-TNFα naphthoquinone antagonist β-lapachone is regulated by calcium overload and CK1α., PMID:33749832
Kinase-substrate Edge Biomarkers Provide a More Accurate Prognostic Prediction in ER-negative Breast Cancer., PMID:33450402
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer., PMID:32972302
Casein kinase 1α inhibits p53 downstream of MDM2‑mediated autophagy and apoptosis in acute myeloid leukemia., PMID:32901886
The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic., PMID:32728212
RORα phosphorylation by casein kinase 1α as glucose signal to regulate estrogen sulfation in human liver cells., PMID:32686824
MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling., PMID:32511789
Loss of lenalidomide-induced megakaryocytic differentiation leads to therapy resistance in del(5q) myelodysplastic syndrome., PMID:32251398
Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma., PMID:32029502
Rapid and deep-scale ubiquitylation profiling for biology and translational research., PMID:31953384
CK1α, CK1δ, and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis., PMID:31932442
Tumor-derived CK1α mutations enhance MDMX inhibition of p53., PMID:31462704
For research use only. Not for human or drug use.
