Catalog No.
YHE56501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro39-Ser281
Predicted molecular weight
29.22 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P48200
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IRP2, Iron-responsive element-binding protein 2, IREB2, IRE-BP 2, Iron regulatory protein 2
Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway., PMID:40215776
Autophagy induced by mechanical stress sensitizes cells to ferroptosis by NCOA4-FTH1 axis., PMID:39988734
Oxidative phosphorylation-related genes for prognosis and tumor microenvironment in breast cancer., PMID:39974386
A Multi-omic study integrating plasma protein, multiple tissues, and single-cell identifies RNASET2 as a key gene for lung cancer., PMID:39930075
IREB2 Knockdown Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by TLR4/NF-κB Signaling Inactivation., PMID:39910919
Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels., PMID:39849491
Loss of Iron Regulatory Protein 2 (IRP2) Protects Mice from Lung Inflammation during Bronchoconstriction., PMID:39847706
Iron Regulatory Protein 2 (IRP2) Deficiency Is Protective Against Resistive Breathing-induced Pulmonary Inflammation., PMID:39761600
RTN4IP1 Contributes to ESCC via Regulation of Amino Acid Transporters., PMID:39757767
Modulation of iron metabolism by new chemicals interacting with the iron regulatory system., PMID:39674082
Salmonella enterica serovar typhimurium effectors spiA and spiC promote replication by modulating iron metabolism and oxidative stress., PMID:39674031
Impact of Vitamin A Deficiency on Iron Metabolism and Anemia: A Historical Perspective and Research Advances., PMID:39667365
Interaction Network Characterization of Infectious Bronchitis Virus Nsp2 with Host Proteins., PMID:39591305
Novel biallelic variants in IREB2 cause an early-onset neurodegenerative disorder in a Chinese pedigree., PMID:39587636
Cyclophosphamide-induced testicular injury: the role of chrysin in mitigating iron overload and ferroptosis., PMID:39565397
The deubiquitinase OTUD3 stabilizes IRP2 expression to reduce hippocampal neuron ferroptosis via the p53/PTGS2 pathway to ameliorate cerebral ischemia-reperfusion injury., PMID:39415292
A bulge uridine in the HIF2α IRE allows IRP1 but not IRP2 to selectively regulate HIF2α expression and ensuing EPO levels., PMID:39316647
Nadolol Attenuates Brain Cell Ferroptosis in Ischemic Stroke Rats by Targeting the HOIL-1/IRP2 Pathway., PMID:39252618
Ablation of Iron Regulatory Protein 2 produces a neurological disorder characterized by motor, somatosensory, and executive dysfunction in mice., PMID:39239479
Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer., PMID:39180081
Ubiquitin-specific protease 38 promotes atrial fibrillation in diabetic mice by stabilizing iron regulatory protein 2., PMID:39173894
FGFR1 governs iron homeostasis via regulating intracellular protein degradation pathways of IRP2 in prostate cancer cells., PMID:39154074
Flaxseed Oil Attenuates Intestinal Damage by Regulating Ferroptosis Signaling Pathway Following LPS Challenge in Piglets., PMID:39148171
Hypoxia-inducible factor-1α can reverse the Adriamycin resistance of breast cancer adjuvant chemotherapy by upregulating transferrin receptor and activating ferroptosis., PMID:39120539
Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages., PMID:39047035
The involvement of IRP2-induced ferroptosis through the p53-SLC7A11-ALOX12 pathway in Parkinson's disease., PMID:38936518
Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis., PMID:38773980
Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms., PMID:38773499
Using Biotinylated Iron-Responsive Element to Analyze the Activity of Iron Regulatory Proteins., PMID:38732071
Baicalin enhances the chemotherapy sensitivity of oxaliplatin-resistant gastric cancer cells by activating p53-mediated ferroptosis., PMID:38730240
Attenuation of HOIL-1L ligase activity promotes systemic autoimmune disorders by augmenting linear ubiquitin signaling., PMID:38329126
Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis., PMID:38301068
Impact of miR-29c-3p in the Nucleus Accumbens on Methamphetamine-Induced Behavioral Sensitization and Neuroplasticity-Related Proteins., PMID:38256016
A regulatory module comprising G3BP1-FBXL5-IRP2 axis determines sodium arsenite-induced ferroptosis., PMID:38118197
Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression., PMID:37978473
Boric acid Increases Susceptibility to Chemotherapy by Targeting the Ferritinophagy Signaling Pathway in TMZ Resistant Glioblastoma Cells., PMID:37906374
Hyperbaric oxygen improves cerebral ischemia-reperfusion injury in rats via inhibition of ferroptosis., PMID:37839303
Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease., PMID:37717841
FOXN4 affects myocardial ischemia-reperfusion injury through HIF-1α/MMP2-mediated ferroptosis of cardiomyocytes., PMID:37605566
Activation of Nrf2 inhibits ferroptosis and protects against oxaliplatin-induced ototoxicity., PMID:37523980
Effects of Curcumin on Oxidative Stress and Ferroptosis in Acute Ammonia Stress-Induced Liver Injury in Gibel Carp (Carassius gibelio)., PMID:37047414
Iron response elements (IREs)-mRNA of Alzheimer's amyloid precursor protein binding to iron regulatory protein (IRP1): a combined molecular docking and spectroscopic approach., PMID:36977734
Cellular and Molecular Processes Are Differently Influenced in Primary Neural Cells by Slight Changes in the Physicochemical Properties of Multicore Magnetic Nanoparticles., PMID:36976318
Ferrodifferentiation regulates neurodevelopment via ROS generation., PMID:36929272
Quercetin Inhibits Hephaestin Expression and Iron Transport in Intestinal Cells: Possible Role of PI3K Pathway., PMID:36904205
Lactobacillus johnsonii L531 Ameliorates Salmonella enterica Serovar Typhimurium Diarrhea by Modulating Iron Homeostasis and Oxidative Stress via the IRP2 Pathway., PMID:36904126
Optimization of Biotinylated RNA or DNA Pull-Down Assays for Detection of Binding Proteins: Examples of IRP1, IRP2, HuR, AUF1, and Nrf2., PMID:36835018
Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1., PMID:36829909
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2., PMID:36828914
β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer., PMID:36703130
For research use only. Not for human or drug use.
