Catalog No.
YHE53801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp111-Gln367
Predicted molecular weight
31.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P47972
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NP-II, NP2, Neuronal pentraxin-2, Neuronal pentraxin II, NPTX2
Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer's disease cohort., PMID:40461705
Cerebrospinal fluid proteome profiling across the Alzheimer's disease continuum: a step towards solving the equation for 'X'., PMID:40329321
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease., PMID:40164724
Associations between cerebrospinal fluid synaptic protein biomarkers and cognitive function in bipolar disorder., PMID:40081262
NPTX2 transfection improves synaptic E/I balance and performance in learning impaired aged rats., PMID:40057261
Biological signatures in the Alzheimer's continuum discriminate between diagnosis-related and -unrelated associations to ATN categories., PMID:40046342
Exploring the Relationship Between Serum Neuronal Pentraxin 2 and Poststroke Cognitive Impairment in Patients With First-Episode Acute Ischemic Stroke., PMID:39924979
Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma., PMID:39917460
Chemoproteomics Sheds Light on Epigenetic Targets of [11C]Martinostat in the Human Brain., PMID:39912892
Biomarker treatment effects in two phase 3 trials of gantenerumab., PMID:39887500
Mapping the Cerebrospinal Fluid Proteome in Bipolar Disorder., PMID:39827936
Xixin Decoction May Treat Vascular Dementia by Modulating the NPTX2/C1q/C3 Complement Pathway., PMID:39737553
Hypometabolic mismatch with atrophy and tau pathology in mixed Alzheimer's and Lewy body disease., PMID:39573823
Neonatal hypoxia-ischemia alters the events governing the hippocampal critical period of postnatal synaptic plasticity leading to deficits in working memory in mice., PMID:39486775
miR-133b as a potential regulator of a synaptic NPTX2 protein in Alzheimer's disease., PMID:39289904
Serial Cerebrospinal Fluid Sampling Reveals Trajectories of Potential Synaptic Biomarkers in Early Stages of Alzheimer's Disease., PMID:39121126
Expression of activity-regulated transcripts in pyramidal neurons across the cortical visuospatial working memory network in unaffected comparison individuals and individuals with schizophrenia., PMID:39033685
Cerebrospinal fluid biomarkers and cognitive trajectories in patients with Alzheimer's disease and a history of traumatic brain injury., PMID:38908030
Cerebrospinal fluid synaptic biomarker changes in bipolar disorder - A longitudinal case-control study., PMID:38723679
Inhibition of neuronal pentraxin 2 relieved epileptic seizure via reducing GluA1 phosphorylation., PMID:38597235
Breakthroughs in Alzheimer's Research: A Path to a More Promising Future?, PMID:38584978
Serum NFL and tau, but not serum UCHL-1 and GFAP or CSF SNAP-25, NPTX2, or sTREM2, correlate with delirium in a 3-year retrospective analysis., PMID:38566855
Neuronal pentraxin 2 correlates with neurodegeneration but not cognition in idiopathic normal pressure hydrocephalus (iNPH)., PMID:38393959
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD., PMID:38355792
The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer's disease., PMID:38355535
Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases., PMID:38325331
Aberrant DNA Methylation of NPTX2 as an Indicator of Malignant Behavior in Thymic Epithelial Tumors., PMID:38254821
Emerging perspectives of synaptic biomarkers in ALS and FTD., PMID:38249293
Levels of neuronal pentraxin 2 in plasma is associated with cognitive function in patients with schizophrenia., PMID:38191677
Cerebrospinal fluid NPTX2 changes and relationship with regional brain metabolism metrics across mild cognitive impairment due to Alzheimer's disease., PMID:38157030
Single-cell transcriptomic analysis reveals rich pituitary-Immune interactions under systemic inflammation., PMID:38109308
The pentraxin family in autoimmune disease., PMID:37832905
Synergism of Carbamoylated Erythropoietin and Insulin-like Growth Factor-1 in Immediate Early Gene Expression., PMID:37763230
An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer's disease rat model., PMID:37719746
Assessments of the Utilities of CSF NPTX2 for Disease Progression in Cognitively Normal Individuals Who Progress to Clinical MCI and AD., PMID:37614206
Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer's disease., PMID:37468915
NPTX2 in Cerebrospinal Fluid Predicts the Progression From Normal Cognition to Mild Cognitive Impairment., PMID:37345460
Discovery of Biomarkers for Amyotrophic Lateral Sclerosis from Human Cerebrospinal Fluid Using Mass-Spectrometry-Based Proteomics., PMID:37238921
Quantitative Mass Spectrometry Analysis of Cerebrospinal Fluid Protein Biomarkers in Alzheimer's Disease., PMID:37160957
Decreased expression of synaptic genes in the vestibular ganglion of rodents following subchronic ototoxic stress., PMID:37100209
Sexual Dimorphism in the Closure of the Hippocampal Postnatal Critical Period of Synaptic Plasticity after Intrauterine Growth Restriction: Link to Oligodendrocyte and Glial Dysregulation., PMID:37019088
The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration., PMID:36989373
Synaptic biomarkers in the cerebrospinal fluid associate differentially with classical neuronal biomarkers in patients with Alzheimer's disease and frontotemporal dementia., PMID:36964594
H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/β-catenin and TGF-β pathways., PMID:36703136
NPTX2 Promotes Epithelial-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma through METTL3-Mediated N6-Methyladenosine Methylation of SNAIL., PMID:36638907
Cerebrospinal Fluid Biomarkers of Synaptic Dysfunction are Altered in Parkinson's Disease and Related Disorders., PMID:36504237
The First Pituitary Proteome Landscape From Matched Anterior and Posterior Lobes for a Better Understanding of the Pituitary Gland., PMID:36470533
CSF peptides from VGF and other markers enhance prediction of MCI to AD progression using the ATN framework., PMID:36368195
A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias., PMID:36120776
Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal dementia., PMID:36045450
For research use only. Not for human or drug use.
