Catalog No.
YHE50101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu252
Predicted molecular weight
31.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P46939
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DMDL, DRP-1, UTRN, DRP1, Dystrophin-related protein 1, Utrophin
Machine-guided dual-objective protein engineering for deimmunization and therapeutic functions., PMID:40466641
L-Arginine Activates the Neuregulin-1/ErbB Receptor Signaling Pathway and Increases Utrophin mRNA Levels in C2C12 Cells., PMID:40224962
Activation of endogenous full-length utrophin by MyoAAV-UA as a therapeutic approach for Duchenne muscular dystrophy., PMID:40064877
Human dystrophin tandem calponin homology actin-binding domain crystallized in a closed-state conformation., PMID:40007458
Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy., PMID:39939773
Respiratory pathology in the mdx/utrn -/- mouse: A murine model for Duchenne Muscular Dystrophy (DMD)., PMID:39919154
Targeting EP2 Receptor Improves Muscle and Bone Health in Dystrophin-/-/Utrophin-/- Double-Knockout Mice., PMID:39851544
Correction: Dystrophin- and Utrophin-Based Therapeutic Approaches for Treatment of Duchenne Muscular Dystrophy: A Comparative Review., PMID:39786649
Is Duchenne gene therapy a suitable treatment despite its immunogenic class effect?, PMID:39720847
Molecular pathways involved in the control of contractile and metabolic properties of skeletal muscle fibers as potential therapeutic targets for Duchenne muscular dystrophy., PMID:39717824
Angiopoietin 1 Attenuates Dysregulated Angiogenesis in the Gastrocnemius of DMD Mice., PMID:39519374
Identification and analysis of differentially expressed lncRNAs and their ceRNA networks in DMD/mdx primary myoblasts., PMID:39390091
Exonisation of an intronic L1 element in the dystrophin gene associated with X-linked muscular dystrophy in a Border Collie dog., PMID:39152696
Molecular and Biochemical Therapeutic Strategies for Duchenne Muscular Dystrophy., PMID:39051216
Upregulation of utrophin improves the phenotype of Duchenne muscular dystrophy hiPSC-derived CMs., PMID:39035791
Modulation of Salmonella virulence by a novel SPI-2 injectisome effector that interacts with the dystrophin-associated protein complex., PMID:38904384
3D-QSAR Modeling on 2-Pyrimidine Carbohydrazides as Utrophin Modulators for the Treatment of Duchenne Muscular Dystrophy by Combining CoMFA, CoMSIA, and Molecular Docking Studies., PMID:38882130
Two operational modes of atomic force microscopy reveal similar mechanical properties for homologous regions of dystrophin and utrophin., PMID:38826288
Discovery of Quinazoline and Quinoline-Based Small Molecules as Utrophin Upregulators via AhR Antagonism for the Treatment of Duchenne Muscular Dystrophy., PMID:38771158
Hsa_circ_0009096/miR-370-3p modulates hepatic stellate cell proliferation and fibrosis during biliary atresia pathogenesis., PMID:38766485
Potential limitations of microdystrophin gene therapy for Duchenne muscular dystrophy., PMID:38713520
Hypoxia treatment and resistance training alters microRNA profiling in rats skeletal muscle., PMID:38600177
Inhibition of miR-25 ameliorates cardiac and skeletal muscle dysfunction in aged mdx/utrn haploinsufficient (+/-) mice., PMID:38584818
UTRN as a potential biomarker in breast cancer: a comprehensive bioinformatics and in vitro study., PMID:38565593
The Shot CH1 domain recognises a distinct form of F-actin during Drosophila oocyte determination., PMID:38564309
Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice., PMID:38564291
Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy., PMID:38457407
circ_UTRN inhibits ferroptosis of ARJ21 cells to attenuate acute pancreatitis progression by regulating the miR-760-3p/FOXO1/GPX4 axis., PMID:38379665
Structural Dynamics of Protein Interactions Using Site-Directed Spin Labeling of Cysteines to Measure Distances and Rotational Dynamics with EPR Spectroscopy., PMID:38371230
Gene therapy delivered micro-dystrophins co-localize with transgenic utrophin in dystrophic skeletal muscle fibers., PMID:38301403
Editor's Note on 'ZZ domain is essentially required for the physiological binding of dystrophin and utrophin to β-dystroglycan'., PMID:37996979
Dystrophin- and Utrophin-Based Therapeutic Approaches for Treatment of Duchenne Muscular Dystrophy: A Comparative Review., PMID:37917377
Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury., PMID:37897547
Functional implications of rs9373441 with FOXP3+Treg and Tr1 for the clinical effectiveness of csDMARDs in rheumatoid arthritis., PMID:37866653
Phenotypic features of genetically modified DMD-XKOXWT pigs., PMID:37772130
Mimicking sarcolemmal damagein vitro: a contractile 3D model of skeletal muscle for drug testing in Duchenne muscular dystrophy., PMID:37725998
Comprehensive Genomic Analysis of Puerarin in Inhibiting Bladder Urothelial Carcinoma Cell Proliferation and Migration., PMID:37694778
Correction to: The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophy., PMID:37668344
Mitochondrial dynamics-related genes DRP1 and OPA1 contributes to early diagnosis of cognitive impairment in diabetes., PMID:37563583
In vivo shear wave elasticity imaging for assessment of diaphragm function in muscular dystrophy., PMID:37453552
Valproic acid reduces muscle susceptibility to contraction-induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy., PMID:37381823
Increasing muscle contractility through low-frequency stimulation alters tibial bone geometry and reduces bone strength in mdx and dko dystrophic mice., PMID:37262103
A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [18F]FEPPA PET., PMID:37108685
Actin filaments accumulated in the nucleus remain in the vicinity of condensing chromosomes in the zebrafish early embryo., PMID:37071022
Utrophin correlates with disease severity in Duchenne muscular dystrophy., PMID:37060897
Acute, next-generation AMPK activation initiates a disease-resistant gene expression program in dystrophic skeletal muscle., PMID:37016990
Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition., PMID:36966198
Unusually severe muscular dystrophy upon in-frame deletion of the dystrophin rod domain and lack of compensation by membrane-localized utrophin., PMID:36905929
Micro-dystrophin gene therapy demonstrates long-term cardiac efficacy in a severe Duchenne muscular dystrophy model., PMID:36874243
Correction to: Cardiac and Skeletal Muscle Pathology in the D2/mdx Mouse Model and Caveats Associated with the Quantification of Utrophin., PMID:36856964
For research use only. Not for human or drug use.
