Catalog No.
YHE47701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu303
Predicted molecular weight
36.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P46109
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Crk-like protein, CRKL
The p130Cas-Crk/CrkL Axis: A Therapeutic Target for Invasive Cancers Unveiled by Collaboration Among p130Cas, Crk, and CrkL., PMID:40362257
tRF-5028c disrupts trophoblast function in recurrent spontaneous abortion by inhibiting CRKL-mediated Rap1 signaling pathway., PMID:40045194
CRKL silencing inhibits melanoma growth and enhances its chemotherapy sensitivity through the PI3K/AKT and NLRP3/GSDMD pathways., PMID:40024349
CRKL Gene Deletion in Familial Zinner (OSVIRA) and OHVIRA Syndromes., PMID:39729079
CRKL Enhances YAP Signaling through Binding and JNK/JUN Pathway Activation in Liver Cancer., PMID:39126118
Use of phosphotyrosine-containing peptides to target SH2 domains: Antagonist peptides of the Crk/CrkL-p130Cas axis., PMID:38886037
Risk of meningomyelocele mediated by the common 22q11.2 deletion., PMID:38696583
CRKL but not CRKII contributes to hemin-induced erythroid differentiation of CML., PMID:38683131
CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma., PMID:38403027
Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD., PMID:38387229
Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis., PMID:38052858
Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development., PMID:37702066
Screening and Activity Evaluation of Novel BCR-ABL/T315I Tyrosine Kinase Inhibitors., PMID:37211852
Identification of CRKL as an oncogenic biomarker for prognosis and immunotherapy in melanoma, and its potential molecular mechanism., PMID:37121446
Inhibition of Abl Kinase by Imatinib Can Rescue the Compromised Barrier Function of 22q11.2DS Patient-iPSC-Derived Blood-Brain Barriers., PMID:36766762
Prenatal phenotype of 22q11 micro-duplications: A systematic review and report on 12 new cases., PMID:35026468
Experimental Characterization of the Interaction between the N-Terminal SH3 Domain of Crkl and C3G., PMID:34947971
CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney Development., PMID:34502088
Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction., PMID:34417497
MiR-145 regulates steroidogenesis in mouse primary granulosa cells through targeting Crkl., PMID:34273377
Bifunctional Role of CrkL during Bone Remodeling., PMID:34209812
Central 22q11.2 deletion (LCR22 B-D) in a fetus with severe fetal growth restriction and a mother with severe systemic lupus erythematosus: Further evidence of CRKL haploinsufficiency in the pathogenesis of 22q11.2 deletion syndrome., PMID:34196458
Silencing of the CrkL gene reverses the doxorubicin resistance of K562/ADR cells through regulating PI3K/Akt/MRP1 signaling., PMID:34114685
Crk and CrkL as Therapeutic Targets for Cancer Treatment., PMID:33801580
Cell shape-based chemical screening reveals an epigenetic network mediated by focal adhesions., PMID:33768715
Quantitative assessment of glioblastoma phenotypes in vitro establishes cell migration as a robust readout of Crk and CrkL activity., PMID:33561443
CRKL promotes hepatocarcinoma through enhancing glucose metabolism of cancer cells via activating PI3K/Akt., PMID:33523562
Heterozygosity of murine Crkl does not recapitulate behavioral dimensions of human 22q11.2 hemizygosity., PMID:33269541
Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas., PMID:32873726
Requirement for Crk and CrkL during postnatal lens development., PMID:32736680
Crk1/2 and CrkL play critical roles in maintaining podocyte morphology and function., PMID:32535035
CRKL promotes proliferation, migration, invasion of laryngeal squamous cell carcinoma., PMID:32495882
miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway., PMID:32413671
A novel ETV6-miR-429-CRKL regulatory circuitry contributes to aggressiveness of hepatocellular carcinoma., PMID:32326970
Arg mediates LPS-induced disruption of the pulmonary endothelial barrier., PMID:32240815
Proteomic analysis of desmosomes reveals novel components required for epidermal integrity., PMID:32238101
What lies beneath: Hydra provides cnidarian perspectives into the evolution of FGFR docking proteins., PMID:32198667
Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial-mesenchymal transition and colorectal cancer aggressiveness., PMID:32147820
Xanthoplanine attenuates macrophage polarization towards M1 and inflammation response via disruption of CrkL-STAT5 complex., PMID:32142888
Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis., PMID:32041892
Copy number gains of the putative CRKL oncogene in laryngeal squamous cell carcinoma result in strong nuclear expression of the protein and influence cell proliferation and migration., PMID:31913340
Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex., PMID:31820037
ZEB2-AS1 Accelerates Epithelial/Mesenchymal Transition Through miR-1205/CRKL Pathway in Colorectal Cancer., PMID:31755734
Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2., PMID:31527084
Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks., PMID:31515267
Rare single-nucleotide variants in oculo-auriculo-vertebral spectrum (OAVS)., PMID:31469246
Down-regulation of microRNA-429 alleviates myocardial injury of rats with coronary heart disease., PMID:31438762
Overexpression of CrkL as a novel biomarker for poor prognosis in gastric cancer., PMID:31356198
LncRNA FAL1 promotes the development of oral squamous cell carcinoma through regulating the microRNA-761/CRKL pathway., PMID:31298329
MiR-335 suppresses cell proliferation and migration by upregulating CRKL in bladder cancer., PMID:30964165
For research use only. Not for human or drug use.
