Catalog No.
YHE44301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn49-Leu242
Predicted molecular weight
25.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P43681
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Neuronal acetylcholine receptor subunit alpha-4, NACRA4, CHRNA4
SIRT1-based therapy targets a gene program involved in mitochondrial turnover in a model of retinal neurodegeneration., PMID:40253451
Prenatal Hypoxia Predisposes to Impaired Expression of the chrna4 and chrna7 Genes in Adult Rats without Affecting Acetylcholine Metabolism during Embryonic Development., PMID:39647824
Clinical, molecular, physiologic, and therapeutic feature of patients with CHRNA4 and CHRNB2 deficiency: A systematic review., PMID:39193833
Pathogenic genes implicated in sleep-related hypermotor epilepsy: a research progress update., PMID:38966089
Spermatogonial stem cells in the 129 inbred strain exhibit unique requirements for self-renewal., PMID:38934417
Identification of Polymorphisms in EAAT1 Glutamate Transporter Gene SLC1A3 Associated with Reduced Migraine Risk., PMID:38927733
Identification of ion channel-related genes as diagnostic markers and potential therapeutic targets for osteoarthritis through bioinformatics and machine learning-based approaches., PMID:38767974
Neonicotinoids differentially modulate nicotinic acetylcholine receptors in immature and antral follicles in the mouse ovary†., PMID:38713677
Coordination among frequent genetic variants imparts substance use susceptibility and pathogenesis., PMID:38660223
Autoantibodies against acetylcholine receptors are increased in archived serum samples from patients with schizophrenia., PMID:38508027
Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis., PMID:38003007
Genetic testing in children enrolled in epilepsy surgery program. A real-life study., PMID:37812946
Two novel variants of the STXBP1 and CHRNB2 genes identified in a Chinese boy with refractory seizures and developmental delay., PMID:37706497
Associative gene networks reveal novel candidates important for ADHD and dyslexia comorbidity., PMID:37667328
Expression and role of nicotinic acetylcholine receptors during midbrain dopaminergic neuron differentiation from human induced pluripotent stem cells., PMID:37366076
Use of dual genomic sequencing to screen mitochondrial diseases in pediatrics: a retrospective analysis., PMID:36918699
Nicotinic acetylcholine receptors and epilepsy., PMID:36796465
Detection of mosaic variants using genome sequencing in a large pediatric cohort., PMID:36563179
Genetic Variant in Nicotinic Receptor α4-Subunit Causes Sleep-Related Hyperkinetic Epilepsy via Increased Channel Opening., PMID:36292983
Study on the Potential Mechanism of Semen Strychni against Myasthenia Gravis Based on Network Pharmacology and Molecular Docking with Experimental Verification., PMID:36217431
Spinal cord injury is associated with changes in synaptic properties of the mouse major pelvic ganglion., PMID:36069457
Network Pharmacological Study on the Mechanism of Cynanchum paniculatum (Xuchangqing) in the Treatment of Bungarus multicinctus Bites., PMID:35837378
Mice lacking α4 nicotinic acetylcholine receptors are protected against alcohol-associated liver injury., PMID:35723023
Common and distinguishing genetic factors for substance use behavior and disorder: an integrated analysis of genomic and transcriptomic studies from both human and animal studies., PMID:35491750
High frequency oscillations play important roles in development of epileptogenesis/ictogenesis via activation of astroglial signallings., PMID:35325849
Autosomal dominant sleep-related hypermotor epilepsy caused by a previously unreported CHRNA4 variant., PMID:35093606
Precision treatment with nicotine in autosomal dominant sleep-related hypermotor epilepsy (ADSHE): An observational study of clinical outcome and serum cotinine levels in 17 patients., PMID:34763266
Association Study of Polymorphisms in Neuronal Nicotinic Acetylcholine Receptor Subunit Genes With Schizophrenia in the Han Chinese Population., PMID:34555889
Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats., PMID:34331199
Can rodent models elucidate the pathomechanisms of genetic epilepsy?, PMID:33689168
TSC1 as a Novel Gene for Sleep-Related Hypermotor Epilepsy: A Child with a Mild Phenotype of Tuberous Sclerosis., PMID:33578443
Colocalization of association signals at nicotinic acetylcholine receptor genes between schizophrenia and smoking traits., PMID:33454625
Nicotinic Receptors in Sleep-Related Hypermotor Epilepsy: Pathophysiology and Pharmacology., PMID:33255633
Age-Dependent and Sleep/Seizure-Induced Pathomechanisms of Autosomal Dominant Sleep-Related Hypermotor Epilepsy., PMID:33143372
Cisatracurium stimulates testosterone synthesis in rat and mouse Leydig cells via nicotinic acetylcholine receptor., PMID:33111502
Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy., PMID:32739426
Variants in CHRNB2 and CHRNA4 Identified in Patients with Insular Epilepsy., PMID:32536355
Novel variant in CHRNA4 with benign childhood epilepsy with centrotemporal spikes and contribution to precise medicine., PMID:32342646
Pathomechanism of nocturnal paroxysmal dystonia in autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant α4 subunit of nicotinic ACh receptor., PMID:32169758
Remarkable effect of transdermal nicotine in children with CHRNA4-related autosomal dominant sleep-related hypermotor epilepsy., PMID:32097883
Candidate Genes Associated with Delayed Neuropsychomotor Development and Seizures in a Patient with Ring Chromosome 20., PMID:32082653
Two mutations in the nicotinic acetylcholine receptor subunit A4 (CHRNA4) in a family with autosomal dominant sleep-related hypermotor epilepsy., PMID:32031532
Pathogenesis and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant α4 subunit of nicotinic ACh receptor., PMID:31901135
Sleep-related hypermotor epilepsy (SHE): Contribution of known genes in 103 patients., PMID:31835056
Depletion of miR-380 mitigates human bronchial epithelial cells injury to improve chronic obstructive pulmonary disease through targeting CHRNA4., PMID:31821848
[Association of CHRNA4 gene polymorphisms with response to antidepressant among ethnic Han Chinese]., PMID:31813155
A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans., PMID:31740666
Association Between Nicotine-dependent Gene Polymorphism and Smoking Cessation in Patients With Lung Cancer., PMID:31402126
Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes., PMID:31294817
For research use only. Not for human or drug use.
