Catalog No.
YHE41201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asn205
Predicted molecular weight
25.69 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P43320
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Beta-crystallin B2, CRYBB2, Beta-crystallin Bp, CRYB2A, Beta-B2 crystallin, CRYB2
Proteomic signatures of retinal pigment epithelium-derived exosomes in myopic and non-myopic tree shrew eyes., PMID:40330779
Exploring susceptibility and therapeutic targets for kidney stones through proteome-wide Mendelian randomization., PMID:39530187
Crystallin β-b2 promotes retinal ganglion cell protection in experimental autoimmune uveoretinitis., PMID:39318470
Exome sequencing identifies novel genes underlying primary congenital glaucoma in the National Birth Defects Prevention Study., PMID:38990107
Four mutations identified in Chinese families with autosomal dominant congenital cataracts by next-generation sequencing., PMID:38869770
Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation., PMID:37862216
A Novel CRYBB2 Silent Variant in Autosomal Dominant Congenital Cataracts (ADCC) in Pakistani families., PMID:37680813
Screening the pathogenic causes of congenital cataract via whole exome sequencing technology in three families: Molecular genetics of congenital cataract., PMID:37165913
Variants of BEST1 and CRYBB2 cause a complex ocular phenotype comprising microphthalmia, microcornea, cataract, and vitelliform macular dystrophy: case report., PMID:37076855
High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology., PMID:37048143
Crystallins Play a Crucial Role in Glaucoma and Promote Neuronal Cell Survival in an In Vitro Model Through Modulating Müller Cell Secretion., PMID:35816047
Patterns of Crystallin Gene Expression in Differentiation State Specific Regions of the Embryonic Chicken Lens., PMID:35412582
Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation., PMID:35246225
Identification of the interactions between specific genetic polymorphisms and nutrient intake associated with general and abdominal obesity in middle-aged adults., PMID:35030529
Broadening the Mutation Spectrum in GJA8 and CHMP4B: Novel Missense Variants and the Associated Phenotypes in Six Chinese Han Congenital Cataracts Families., PMID:34722561
Whole-exome sequencing identification of a recurrent CRYBB2 variant in a four-generation Chinese family with congenital nuclear cataracts., PMID:34650623
Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells., PMID:34599192
Deciphering the association of intronic single nucleotide polymorphisms of crystallin gene family with congenital cataract., PMID:34304179
Crystalline gene mutations in Turkish children with congenital cataracts., PMID:33864186
Identification and characterization of six β-crystallin gene mutations associated with congenital cataract in Chinese families., PMID:33594837
The mutation spectrum in familial versus sporadic congenital cataract based on next-generation sequencing., PMID:32883240
Bioenergetic shift and actin cytoskeleton remodelling as acute vascular adaptive mechanisms to angiotensin II in murine retina and ophthalmic artery., PMID:32513477
A novel CRYBB2 mutation causes autosomal dominant cataract: A report from a Chinese family., PMID:32498547
Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function., PMID:32317624
Mutation screening of crystallin genes in Chinese families with congenital cataracts., PMID:31523120
Molecular characterization of the human lens epithelium-derived cell line SRA01/04., PMID:31479653
Proteomic analysis of the aqueous humour in eyes with pseudoexfoliation syndrome., PMID:30842085
Race influences survival in glioblastoma patients with KPS ≥ 80 and associates with genetic markers of retinoic acid metabolism., PMID:30706176
A novel mutation in the CRYAA gene associated with congenital cataract and microphthalmia in a Chinese family., PMID:30340470
Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice., PMID:30291584
MiR-326 antagomir delays the progression of age-related cataract by upregulating FGF1-mediated expression of betaB2-crystallin., PMID:30268497
Crybb2 associates with Tmsb4X and is crucial for dendrite morphogenesis., PMID:29864422
A CRYBB2 mutation in a Taiwanese family with autosomal dominant cataract., PMID:29395391
Mutations in crystallin genes result in congenital cataract associated with other ocular abnormalities., PMID:29386872
Two novel mutations identified in ADCC families impair crystallin protein distribution and induce apoptosis in human lens epithelial cells., PMID:29259299
High-Throughput Genetic Screening of 51 Pediatric Cataract Genes Identifies Causative Mutations in Inherited Pediatric Cataract in South Eastern Australia., PMID:28839118
A novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family., PMID:28546921
Identification of a De Novo 3bp Deletion in CRYBA1/A3 Gene in Autosomal Dominant Congenital Cataract., PMID:28120589
Long non-coding RNAs regulate effects of β-crystallin B2 on mouse ovary development., PMID:27666820
A Common Ancestral Mutation in CRYBB3 Identified in Multiple Consanguineous Families with Congenital Cataracts., PMID:27326458
Early detection of bilateral cataracts in utero may represent a manifestation of severe congenital disease., PMID:27256633
From eyeless to neurological diseases., PMID:26593886
Analyzing the Association of Polymorphisms in the CRYBB2 Gene with Prostate Cancer Risk in African Americans., PMID:25964531
Congenital cataracts: de novo gene conversion event in CRYBB2., PMID:25489230
Crybb2 deficiency impairs fertility in female mice., PMID:25245288
Molecular and structural analysis of genetic variations in congenital cataract., PMID:24319337
A missense mutation in CRYBB2 leads to progressive congenital membranous cataract by impacting the solubility and function of βB2-crystallin., PMID:24312286
Long-term neuroprotective effects of NT-4-engineered mesenchymal stem cells injected intravitreally in a mouse model of acute retinal injury., PMID:24265016
Crybb2 coding for βB2-crystallin affects sensorimotor gating and hippocampal function., PMID:24096375
A CRYGC gene mutation associated with autosomal dominant pulverulent cataract., PMID:23954869
For research use only. Not for human or drug use.
