Catalog No.
YHE40601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe186-Phe448
Predicted molecular weight
32.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P43250
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GRK6, GPRK6, G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6
Potent, Selective, and Drug-like G Protein-coupled Receptor Kinase 5 and 6 Inhibitors: Design, Synthesis, and X-ray Structural Studies., PMID:40388590
Role of the Palmitoyl Group and of the Amphipathic α Helix in the Membrane Binding of the C-Terminus of G-Protein Receptor Kinase 4α/β., PMID:39977231
Ligand-based cheminformatics and free energy-inspired molecular simulations for prioritizing and optimizing G-protein coupled receptor kinase-6 (GRK6) inhibitors in multiple myeloma treatment., PMID:39824142
GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis., PMID:39741338
Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors., PMID:39549325
Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors., PMID:39468452
The role of polo-like kinases 2 in the proteasomal and lysosomal degradation of alpha-synuclein in neurons., PMID:39436202
Distinct Role of GRK3 in Platelet Activation by Desensitization of G Protein-Coupled Receptors., PMID:39419098
[Screening and validation of therapeutic targets for chronic sinusitis with nasal polyps based on proteomics]., PMID:39107122
Long-read Ribo-STAMP simultaneously measures transcription and translation with isoform resolution., PMID:38906680
Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons., PMID:38883814
ARF6 promotes Streptococcus suis suilysin induced apoptosis in HBMECs., PMID:38663699
The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation., PMID:38461904
GPCR kinases differentially modulate biased signaling downstream of CXCR3 depending on their subcellular localization., PMID:38349966
Therapeutic potential and protective role of GRK6 overexpression in pulmonary arterial hypertension., PMID:37742818
miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population., PMID:37706561
G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions., PMID:37660910
GRK6 palmitoylation increasing its membrance translocation promotes LPS-induced inflammation by PI3K/ AKT pathway in kuppfer cells., PMID:37012861
The Role of G Protein-Coupled Receptor Kinase 6 Regulation in Inflammation and Pain., PMID:36555521
Bioinformatics Prediction and Machine Learning on Gene Expression Data Identifies Novel Gene Candidates in Gastric Cancer., PMID:36553500
Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions., PMID:36451830
M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6., PMID:36261031
G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin., PMID:36030052
Nanoluciferase-based complementation assay for systematic profiling of GPCR-GRK interactions., PMID:35623709
Hypergastrinemia, a clue leading to the identification of an atypical form of diabetes mellitus type 2., PMID:35623402
Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress., PMID:35349212
Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots., PMID:35163118
Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice., PMID:35152546
Correction to "Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma"., PMID:34963044
The Predominant Role of Arrestin3 in General GPCR Desensitization in Platelets., PMID:34682866
MXD3 as an onco-immunological biomarker encompassing the tumor microenvironment, disease staging, prognoses, and therapeutic responses in multiple cancer types., PMID:34584637
Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma., PMID:34291633
GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma., PMID:34136390
Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma., PMID:33971243
Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site., PMID:33600497
Inhibition of G Protein-Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth., PMID:33158816
[Effect of NUDT21 on Alternative Splicing of Transcripts in K562 Cells]., PMID:33067945
The Roles of GRKs in Hemostasis and Thrombosis., PMID:32731360
Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization., PMID:32486261
Downregulation of GRK6 in arcuate nucleus promotes chronic visceral hypersensitivity via NF-κB upregulation in adult rats with neonatal maternal deprivation., PMID:32484026
ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins., PMID:32391018
S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease., PMID:32343709
Differential Role of Serines and Threonines in Intracellular Loop 3 and C-Terminal Tail of the Histamine H4 Receptor in β-Arrestin and G Protein-Coupled Receptor Kinase Interaction, Internalization, and Signaling., PMID:32296771
GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets., PMID:31899801
The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry., PMID:31694949
Pharmacological antagonism of histamine H2R ameliorated L-DOPA-induced dyskinesia via normalization of GRK3 and by suppressing FosB and ERK in PD., PMID:31306812
Age-dependent effects of dopamine receptor inactivation on cocaine-induced behaviors in male rats: Evidence of dorsal striatal D2 receptor supersensitivity., PMID:31304635
MiR-19b-3p attenuates IL-1β induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6., PMID:31227976
The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors., PMID:31088898
Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPα, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells., PMID:30984536
For research use only. Not for human or drug use.
