Catalog No.
EHE39701
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Gly559
Predicted molecular weight
62.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P43121
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD146, Melanoma cell adhesion molecule, S-endo 1 endothelial-associated antigen, Melanoma-associated antigen A32, MUC18, MCAM, Melanoma-associated antigen MUC18, Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12
Myometrial extracellular vesicles promoted endometrial mesenchymal stem/stromal cells to self-renewal via jag1-mediated notch signaling., PMID:40495149
[Correlation between soluble CD146 and systemic vasculitis]., PMID:40484821
Evaluation of Platelet Lysate-Based Medium and Protein Substrate for HUVEC Culture and Expansion., PMID:40427014
A role for fibroblast and mural cell subsets in a nerve ligation model of neuropathic pain?, PMID:40381746
Abundance of a metabolically active subpopulation in dedifferentiated adipocytes inversely correlates with body mass index., PMID:40348015
A model workflow for microfluidic enrichment and genetic analysis of circulating melanoma cells., PMID:40316673
Extracellular Vesicles Analysis as Possible Signatures of Antiphospholipid Syndrome Clinical Features., PMID:40243411
Pdgfrβ marks distinct mesenchymal and pericyte populations within the periosteum with overlapping cellular features., PMID:40237625
RUNX1 is a key inducer of human hematopoiesis controlling non-hematopoietic mesodermal development., PMID:40220285
Phillyrin from Forsythia suspensa suppresses the proliferation, angiogenesis, and metastasis of colorectal cancer via targeting CD147., PMID:40210179
Involvement of CD146 in the Cryptococcus neoformans adhesion and infection of brain endothelial cells., PMID:40208055
Evaluation of Novel Therapeutic Agents for Modulation of the Inflammatory Response in Rotator Cuff Tendinopathy Utilizing a Mouse Model of Subacromial Impingement., PMID:40159684
Melanoma Cell Adhesion Molecule Plays a Pivotal Role in Proliferation, Migration, Tumor Immune Microenvironment, and Immunotherapy in Colorectal Cancer., PMID:40042109
CD146 regulates the stemness and chemoresistance of hepatocellular carcinoma via JAG2-NOTCH signaling., PMID:40032820
MCAM is a prognostic biomarker in patients with liver cirrhosis and HCC., PMID:39992088
Pro-inflammatory and anti-inflammatory immune biomarkers as predictors of neurodevelopment in young children exposed to HIV., PMID:39970188
MCAM Expression Facilitates Melanoma-Endothelial Interactions and Promotes Metastatic Disease Progression., PMID:39945026
Investigation of Angiogenic Potential in CD146-Positive Stem Cells Derived from Human Exfoliated Deciduous Teeth., PMID:39940740
Assessment of Phage-Displayed Peptides Targeting Cancer Cell Surface Proteins: A Comprehensive Molecular Docking Study., PMID:39905270
Ezrin Polarization as a Diagnostic Marker for Circulating Tumor Cells in Hepatocellular Carcinoma., PMID:39791707
Missing the mark(ers): circulating endothelial cells and endothelial-derived extracellular vesicles are elevated in sickle cell disease plasma., PMID:39776915
Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice., PMID:39723966
CD146⁺ Endothelial Cells Facilitate Renal Interstitial Fibrosis Through Endothelial-to-Mesenchymal Transition., PMID:39654278
Inhibition of soluble epoxide hydrolase reverses bone loss in periodontitis by upregulating EMCN and inhibiting osteoclasts., PMID:39587694
In Vivo and In Vitro Response to a Regenerative Dental Scaffold., PMID:39517658
Antigen targeting and anti-tumor activity of a novel anti-CD146 212Pb internalizing alpha-radioimmunoconjugate against malignant peritoneal mesothelioma., PMID:39472474
Hepatic Stellate Cell-mediated Increase in CCL5 Chemokine Expression after X-ray Irradiation Determined In Vitro and In Vivo., PMID:39449628
Soluble CD146 Cooperates with VEGFa to Generate an Immunosuppressive Microenvironment in CD146-Positive Tumors: Interest of a Combined Antibody-Based Therapy., PMID:39431288
Melanoma Cell Adhesion Molecule (CD 146) in Endometrial Physiology and Disorder., PMID:39400880
Immunohistochemical and ultrastructural identification of telocytes in the infantile hemangioma., PMID:39397344
Human mesenchymal stem/stromal cell-derived extracellular vesicle transport in meniscus fibrocartilage., PMID:39396193
The vasculogenic mimicry, CD146+ and CD105+ microvessel density in the prognosis of endometrioid endometrial adenocarcinoma: a single-centre immunohistochemical study., PMID:39392041
Standard chemotherapy impacts on in vitro cellular heterogeneity in spheroids enriched with cancer stem cells (CSCs) derived from triple-negative breast cancer cell line., PMID:39357337
Characterization and angiogenic potential of CD146+ endometrial stem cells., PMID:39334237
Accelerating histopathology workflows with generative AI-based virtually multiplexed tumour profiling., PMID:39309216
Netrin-1-CD146 and netrin-1-S100A9 are associated with early stage of lymph node metastasis in colorectal cancer., PMID:39261771
Perivascular phosphorylated TDP-43 inclusions are associated with Alzheimer's disease pathology and loss of CD146 and Aquaporin-4., PMID:39251230
Galectin-3 and Soluble CD146 Identify Cardiorenal Injuries in Severe Burn Patients: A Biomarker-Based Approach., PMID:39134005
Chemical Coaxing of Mesenchymal Stromal Cells by Drug Repositioning for Nestin Induction., PMID:39125577
Preclinical ImmunoPET Imaging Using a Zr-89-Labeled Anti-CD146 Monoclonal Antibody for Diagnosis of Melanoma., PMID:39077827
CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway., PMID:38908086
Exosomes multiplex profiling, a promising strategy for early diagnosis of laryngeal cancer., PMID:38902710
In Vitro Cell Surface Marker Expression on Mesenchymal Stem Cell Cultures does not Reflect Their Ex Vivo Phenotype., PMID:38837115
The Role of Pericyte Migration and Osteogenesis in Periodontitis., PMID:38822570
Interleukin 6 at menstruation promotes the proliferation and self-renewal of endometrial mesenchymal stromal/stem cells through the WNT/β-catenin signaling pathway., PMID:38765018
Neovascularization by DPSC-ECs in a Tube Model for Pulp Regeneration Study., PMID:38716736
CD146 Promotes EMT-Mediated Migration and Invasion of NSCLC via PI3K/Akt Signaling Pathway., PMID:38682195
CD146, a therapeutic target involved in cell plasticity., PMID:38613742
An immune sandwich electrochemical biosensor based on triple-modified zirconium derivatives for detection of CD146 in serum., PMID:38599037
Specific lipid magnetic sphere sorted CD146-positive bone marrow mesenchymal stem cells can better promote articular cartilage damage repair., PMID:38561728
For research use only. Not for human or drug use.
