Catalog No.
YHE39001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala382-Arg501
Predicted molecular weight
15.89 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P43026
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Growth/differentiation factor 5, BMP14, BMP-14, Radotermin, GDF-5, Bone morphogenetic protein 14, GDF5, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, CDMP1, Cartilage-derived morphogenetic protein 1, LPS-associated protein 4
GDF5 rs143384 Polymorphism Associated with Developmental Dysplasia of the Hip in Brazilian Patients: A Case-Control Study., PMID:40507824
Creb5 controls its own expression and directly induces the joint interzone regulatory program., PMID:40472036
METTL14 regulates chondrogenesis through the GDF5-RUNX-extracellular matrix gene axis during limb development., PMID:40307229
PDGFRα signaling regulates cartilage and fibrous tissue differentiation during synovial joint development., PMID:40301343
A cross-sectional study on the assessment of COLL11A1, VEGF, and GDF5 gene polymorphisms in Turkish patients with primary knee osteoarthritis., PMID:39953483
Genetics of hip dysplasia - a systematic literature review., PMID:39354451
Intervertebral disc degenerative disease in South Africa: a case-control analysis of selected gene variants., PMID:39287911
Decisive gene strategy on osteoarthritis: a comprehensive whole-literature based approach for conclusive gene targets., PMID:39248710
Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee., PMID:39103079
A systematic review and cross-database analysis of single nucleotide polymorphisms underlying hip morphology and osteoarthritis reveals shared mechanisms., PMID:38852879
The role of GDF5 in regulating enthesopathy development in the Hyp mouse model of XLH., PMID:38836497
Correlation of growth differentiation factor-5 + 104T>C polymorphism with the risk of knee, hand, and hip osteoarthritis: a case-control study and meta-analysis based on 47 case-control studies., PMID:38743962
GDF5 as a rejuvenating treatment for age-related neuromuscular failure., PMID:38584513
HOXA10 promotes Gdf5 expression in articular chondrocytes., PMID:38123662
[GDF5: a therapeutic candidate for combating sarcopenia]., PMID:37975770
Influence of Different Evolutive Forces on GDF5 Gene Variability., PMID:37895244
The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis., PMID:37817264
Skeletal Muscle-Derived Exosomal miR-146a-5p Inhibits Adipogenesis by Mediating Muscle-Fat Axis and Targeting GDF5-PPARγ Signaling., PMID:36901991
LINC00313 promotes the proliferation and inhibits the apoptosis of chondrocytes via regulating miR-525-5p/GDF5 axis., PMID:36823651
WNT1 expression influences the development of dysplasia of the hip via regulating RBPMS2/NOG-BMP2/4-GDF5- WISP2 pathway., PMID:35675541
Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis., PMID:35563063
GDF5+ chondroprogenitors derived from human pluripotent stem cells preferentially form permanent chondrocytes., PMID:35451016
Long non-coding RNA SNHG5 promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the miR-212-3p/GDF5/SMAD pathway., PMID:35346361
Effect of lentivirus-mediated growth and differentiation factor-5 transfection on differentiation of rabbit nucleus pulposus mesenchymal stem cells., PMID:35022077
Association Analysis of GDF5 and Contributing Factors in Developmental Dysplasia of the Hip in Infants., PMID:34734566
Application of 3D MAPs pipeline identifies the morphological sequence chondrocytes undergo and the regulatory role of GDF5 in this process., PMID:34508093
Joint disease-specificity at the regulatory base-pair level., PMID:34230488
The effect of common variants in GDF5 gene on the susceptibility to chronic postsurgical pain., PMID:34210342
Genetic Study of IL6, GDF5 and PAPPA2 in Association with Developmental Dysplasia of the Hip., PMID:34203285
A GDF5 frameshift mutation segregating with Grebe type chondrodysplasia and brachydactyly type C+ in a 6 generations family: Clinical report and mini review., PMID:33872773
Frequency of Growth Differentiation Factor 5 rs143383 and asporin D-repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran., PMID:33861510
Systemic Overexpression of GDF5 in Adipocytes but Not Hepatocytes Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver in Mice., PMID:33542911
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women., PMID:33510174
GDF-5 induces epidermal stem cell migration via RhoA-MMP9 signalling., PMID:33369147
GDF5 mutation case report and a systematic review of molecular and clinical spectrum: Expanding current knowledge on genotype-phenotype correlations., PMID:33333243
Dysregulated BMP signaling through ACVR1 impairs digit joint development in fibrodysplasia ossificans progressiva (FOP)., PMID:33217406
CDMP1 promotes type II collagen and aggrecan synthesis of nucleus pulposus cell via the mediation of ALK6., PMID:33215411
Dose-Response Tendon-Specific Markers Induction by Growth Differentiation Factor-5 in Human Bone Marrow and Umbilical Cord Mesenchymal Stem Cells., PMID:32824547
Identification of TGFβ signatures in six murine models mimicking different osteoarthritis clinical phenotypes., PMID:32659345
A single cell transcriptional atlas of early synovial joint development., PMID:32580935
Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex., PMID:32576689
Contralesional Application of Transcranial Direct Current Stimulation on Functional Improvement in Ischemic Stroke Mice., PMID:32521221
Tendon and Cytokine Marker Expression by Human Bone Marrow Mesenchymal Stem Cells in a Hyaluronate/Poly-Lactic-Co-Glycolic Acid (PLGA)/Fibrin Three-Dimensional (3D) Scaffold., PMID:32443833
Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk., PMID:32220312
A novel variant near LSP1P3 is associated with knee osteoarthritis in the Chinese population., PMID:32103374
Increasing the Medium Osmolarity Reduces the Inflammatory Status of Human OA Chondrocytes and Increases Their Responsiveness to GDF-5., PMID:31947660
A Meta-analysis Assessing the Association Between COL11A1 and GDF5 Genetic Variants and Intervertebral Disc Degeneration Susceptibility., PMID:31923126
microRNA-132 inhibits osteogenic differentiation of periodontal ligament stem cells via GDF5 and the NF-κB signaling pathway., PMID:31718857
Cells from a GDF5 origin produce zonal tendon-to-bone attachments following anterior cruciate ligament reconstruction., PMID:31596513
GDF5 Promotes White Adipose Tissue Thermogenesis via p38 MAPK Signaling Pathway., PMID:31553232
For research use only. Not for human or drug use.
