Catalog No.
YHE38401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu469-Glu721
Predicted molecular weight
31.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P42892
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ECE1, Endothelin-converting enzyme 1, ECE-1
Network pharmacology, prognostic analysis and experimental validation elucidate the therapeutic mechanism of Dingxiang Guanshitong in esophageal cancer., PMID:40436970
Myricetin Exerts Antibiofilm Effects on Candida albicans by Targeting the RAS1/cAMP/EFG1 Pathway and Disruption of the Hyphal Network., PMID:40422732
Transcriptomic insights into Candida albicans adaptation to an anaerobic environment., PMID:40401963
Candidalysin biology and activation of host cells., PMID:40293285
Chemical composition of the traditional Chinese medicine compound (ICAM), its antifungal effects against Candida albicans, and the underlying Mechanisms: Therapeutic potential and safety evaluation for vulvovaginal candidiasis., PMID:40254107
Characterisation of macrophages in healthy and diseased livers in mice: identification of necrotic lesion-associated macrophages., PMID:40212045
Candida albicans biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses., PMID:40172491
Targeting biofilm formation in Candida albicans with halogenated pyrrolopyrimidine derivatives., PMID:40121868
The metabolism of big endothelin-1 axis and lipids affects carotid atherosclerotic plaque stability - the possible opposite effects of treatment with statins and aspirin., PMID:40063220
Gene Expression Signatures of Porcine Bone Marrow-Derived Antigen-Presenting Cells Infected with Classical Swine Fever Virus., PMID:40006915
Breaking Barriers: Candidalysin Disrupts Epithelial Integrity and Induces Inflammation in a Gut-on-Chip Model., PMID:39998106
Associations between plasma proteins and psychological wellbeing: evidence from over 20 years of the English Longitudinal Study of Ageing., PMID:39974132
Aloin remodels the cell wall of Candida albicans to reduce its hyphal virulence against oral candidiasis., PMID:39853490
From High Protection to Lethal Effect: Diverse Outcomes of Immunization Against Invasive Candidiasis with Different Candida albicans Extracellular Vesicles., PMID:39796100
Rosmarinic Acid Exhibits Antifungal and Antibiofilm Activities Against Candida albicans: Insights into Gene Expression and Morphological Changes., PMID:39590670
DNA damage repair factor Rad18 controls virulence partially via transcriptional suppression of genes HWP1 and ECE1 in Candida albicans., PMID:39573927
Chronic Sleep Deprivation Altered the Expression of Memory-Related Genes and Caused Cognitive Memory Dysfunction in Mice., PMID:39519186
Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells., PMID:39443981
Respiratory dysfunction in old mice could be related to inflammation and lung fibrosis induced by hyperphosphatemia., PMID:39155424
Endothelin-1 down-regulates nuclear factor erythroid 2-related factor-2 and contributes to perivascular adipose tissue dysfunction in obesity., PMID:39136472
Exome sequencing identifies novel genetic variants associated with varicose veins., PMID:38980841
Variations in candidalysin amino acid sequence influence toxicity and host responses., PMID:38953356
Comprehensive analysis of the endothelin system in the kidneys of mice, rats, and humans., PMID:38904098
Antifungal, anti-biofilm, and anti-hyphal properties of N-substituted phthalimide derivatives against Candida species., PMID:38903941
Regulation of candidalysin underlies Candida albicans persistence in intravascular catheters by modulating NETosis., PMID:38885290
Heterologous expression of the insect SVWC peptide WHIS1 inhibits Candida albicans invasion into A549 and HeLa epithelial cells., PMID:38873147
Hypoxia related genes modulate in similar fashion in skin fibroblast cells of yak (Bos grunniens) adapted to high altitude and native cows (Bos indicus) adapted to tropical climate during hypoxia stress., PMID:38814473
Artemisinin May Disrupt Hyphae Formation by Suppressing Biofilm-Related Genes of Candida albicans: In Vitro and In Silico Approaches., PMID:38666986
Endothelin-converting Enzyme-1b Genetic Variants Increase the Risk of Coronary Artery Ectasia., PMID:38625594
Hypoxia-inducible factor-1α contributes to the proliferation of cholesteatoma keratinocytes through regulating endothelin converting enzyme 1 expression., PMID:38525120
Label-free quantitative proteomics reveals the mechanisms of Aurora kinase B in renal cell carcinoma., PMID:38516642
The hyphal-specific toxin candidalysin promotes fungal gut commensalism., PMID:38448595
Global fungal-host interactome mapping identifies host targets of candidalysin., PMID:38413612
Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences., PMID:38388771
The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain dependent., PMID:38376205
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis., PMID:38349176
Immunity to pathogenic mucosal C. albicans infections mediated by oral megakaryocytes activated by IL-17 and candidalysin., PMID:38246240
Inhibiting pathogenicity of vaginal Candida albicans by lactic acid bacteria and MS analysis of their extracellular compounds., PMID:38168754
Novel urine cell-free DNA methylation markers for hepatocellular carcinoma., PMID:38062093
Possible Molecular Targeting of Biofilm-Associated Genes by Nano-Ag in Candida albicans., PMID:37922031
A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT)., PMID:37897251
Nascent Aβ42 Fibrillization in Synaptic Endosomes Precedes Plaque Formation in a Mouse Model of Alzheimer's-like β-Amyloidosis., PMID:37884349
Candida albicans induces neutrophil extracellular traps and leucotoxic hypercitrullination via candidalysin., PMID:37795769
Involvement of the aryl hydrocarbon receptor (AhR) in the mechanism of action of elastin-derived peptide (VGVAPG) and its impact on neurosteroidogenesis., PMID:37769996
Fluconazole-Induced Protein Changes in Osteogenic and Immune Metabolic Pathways of Dental Pulp Mesenchymal Stem Cells of Osteopetrosis Patients., PMID:37762144
Effect of NLRP3 deficiency on cytotoxic and IL-1β-producing activities of synthetic candidalysin peptide., PMID:37659475
Molecular basis of selective amyloid-β degrading enzymes in Alzheimer's disease., PMID:37622248
CircECE1 promotes osteosarcoma progression through regulating RAB3D by sponging miR-588., PMID:37559140
Cardioprotective effect of 2-methoxy phenol derivatives against oxidative stress-induced vascular complications: An integrated in vitro, in silico, and in vivo investigation., PMID:37531779
Shikonin Inhibits Candida albicans Biofilms via the Ras1-cAMP-Efg1 Signalling Pathway., PMID:37384115
For research use only. Not for human or drug use.
