Catalog No.
YHE38301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser803-Lys941
Predicted molecular weight
17.99 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P42858
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Huntingtin, HD protein, Huntington disease protein, HTT, HD, IT15
Note
For research use only.
Revisiting huntingtin activity and localization signals in the context of protein structure., PMID:39973382
Absence of hippocampal pathology persists in the Q175DN mouse model of Huntington's disease despite elevated HTT aggregation., PMID:39973391
Multiple Copper Ions Bind to and Promote the Oligomerization of Huntingtin Protein with Nonpathological Repeat Expansions., PMID:39984289
Advances in Huntington's Disease Biomarkers: A 10-Year Bibliometric Analysis and a Comprehensive Review., PMID:40001897
Transcriptome Study in Sicilian Patients with Huntington's Disease., PMID:40002561
The therapeutic potential of (R)-carvedilol in Huntington's disease through enhancement of autophagy-lysosomal pathway via GSK-3β inhibition., PMID:40011132
Downregulation of Pten Improves Huntington's Disease Phenotype by Reducing Htt Aggregates and Cell Death., PMID:40042729
Intersecting impact of CAG repeat and Huntingtin knockout in stem cell-derived cortical neurons., PMID:40060574
CAG Repeat Instability and Region-Specific Gene Expression Changes in the SCA12 Brain., PMID:40075006
The breaking point where repeat expansion triggers neuronal collapse in Huntington's disease., PMID:40081335
Transcriptomic analysis of intracellular RNA granules and small extracellular vesicles: Unmasking their overlap in a cell model of Huntington's disease., PMID:40090627
Structural-functional analyses of the huntingtin/HAP40 complex in Drosophila and humans., PMID:40091796
Hyalinizing trabecular tumor of the thyroid: Interest of GLIS3 immunohistochemical study to detect PAX8::GLIS3 rearrangement., PMID:40122401
Molecular mechanisms and biomarkers in neurodegenerative disorders: a comprehensive review., PMID:40138119
Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures., PMID:40169779
Exploring Cordycepin as a Neuroprotective Agent in Huntington's Disease: In Vitro and In Vivo Insights., PMID:40202221
Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5., PMID:40204699
Altered huntingtin-chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease., PMID:40205980
Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress., PMID:40234398
Intersecting impact of CAG repeat and huntingtin knockout in stem cell-derived cortical neurons., PMID:40258535
Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification., PMID:40259428
Opposing roles for GSK3β and ERK1-dependent phosphorylation of huntingtin during neuronal dysfunction and cell death in Huntington's disease., PMID:40263294
Kinetin mediated mutant huntingtin phosphorylation restores multiple dysregulated pathways in a cell line model of Huntington's disease., PMID:40267238
Antioxidant and Anti-Inflammatory Defenses in Huntington's Disease: Roles of NRF2 and PGC-1α, and Therapeutic Strategies., PMID:40283130
Regulation of Genome Architecture in Huntington's Disease., PMID:40287840
[Finally, an understanding of Huntington's disease!]., PMID:40293154
PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites., PMID:40304179
Regulation of misfolded protein aggregation and degradation by SUMOylation in budding yeast., PMID:40305096
Immobilizing the Endogenous 5-Hydroxytryptamine Transporter by Ligand-Directed and Proximity-Catalyzed Acyl Imidazole Chemistry for Affinity Chromatographic Analysis., PMID:40317770
Targeted proteomic biomarker profiling using NULISA in a cohort enriched with risk for Alzheimer's disease and related dementias., PMID:40318118
Exploring the association between serotonin transporter promoter region methylation levels and depressive symptoms: a systematic review and multi-level meta-analysis., PMID:40319044
Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington's disease human cerebral cortex., PMID:40319093
Cerulenin Partially Corrects the Disrupted Developmental Transcriptomic Signature in Huntington's Disease Striatal Medium Spiny Neurons., PMID:40336225
Dopamine Receptor D3 Induces Transient, mTORC1-Dependent Autophagy That Becomes Persistent, AMPK-Mediated, and Neuroprotective in Experimental Models of Huntington's Disease., PMID:40358175
Genetic variants of SLC6A4 and risk of coronary artery disease: insights from North Indian population., PMID:40369544
Berberine can be a Potential Therapeutic Agent in Treatment of Huntington's Disease: A Proposed Mechanistic Insight., PMID:40377895
mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance., PMID:40392702
A potential role for NADPH oxidase (NOX1/2) in mutant huntingtin-induced anomalous neurite outgrowth., PMID:40412581
Evidence of an unprecedented cytoplasmic function of DDX11, the Warsaw breakage syndrome DNA helicase, in regulating autophagy., PMID:40413757
Microbiota dysbiosis impact on the immune system dysregulation in Huntington's disease (HD)., PMID:40414643
The influence of genetic factors on the severity of anxiety and depressive symptoms and the choice of coping strategies in reproductive tract cancer-a preliminary study., PMID:40416692
Base editing of trinucleotide repeats that cause Huntington's disease and Friedreich's ataxia reduces somatic repeat expansions in patient cells and in mice., PMID:40419681
Accurate Quantification of Mutant and Wild-Type polyQ Proteins Using Simple Western Capillary Immunoassays., PMID:40450087
Navigating the neuronal recycling bin: Another look at huntingtin in coordinating autophagy., PMID:40475846
Concentration-dependent structural transition of huntingtin protein in Huntington's disease., PMID:40482382
Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome-Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development., PMID:40485115
Genetic modifiers of somatic expansion and clinical phenotypes in Huntington's disease highlight shared and tissue-specific effects., PMID:40490511
Direct Observation of Secondary Nucleation in Huntingtin Amyloid Formation by High-Speed Atomic Force Microscopy., PMID:40505012
Restoring endogenous Dlg4/PSD95 expression by an artificial transcription factor ameliorates cognitive and motor learning deficits in the R6/2 mouse model of Huntington's disease., PMID:40506760
For research use only. Not for human or drug use.
