Catalog No.
YHE36001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly334-Thr452
Predicted molecular weight
15.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P42575
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protease ICH-1, ICH1, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD2, CASP-2, Caspase-2, CASP2, NEDD-2
Spermine Enhances Cholesterol Effluence of Macrophages Through Caspase 2-Mediated Autophagy., PMID:40415363
The investigation of apoptosis-related genes in periodontitis., PMID:40355964
Reengineering of Circularly Permuted Caspase-2 to Enhance Enzyme Stability and Enable Crystallographic Studies., PMID:40117490
Physicochemical and colon cancer HT-29 cell inhibitory property of homogeneous polysaccharide from Stropharia rugosoannulata., PMID:40081691
Integrative analysis of PANoptosis-related genes in diabetic retinopathy: machine learning identification and experimental validation., PMID:39697326
Ally or traitor: the dual role of p62 in caspase-2 regulation., PMID:39543123
Cellular communication network 1 promotes CASP2 mRNA expression but suppresses its protein translation in esophageal adenocarcinoma., PMID:39524140
The Impact of Acute Ammonia Nitrogen Stress on Serum Biochemical Indicators and Spleen Gene Expression in Juvenile Yellowfin Tuna (Thunnus albacares)., PMID:39518812
Caspase-2 is a condensate-mediated deubiquitinase in protein quality control., PMID:39482354
Caspase-2 kills cells with extra centrosomes., PMID:39475598
Identification of cuproptosis-related genes in Alzheimer's disease based on bioinformatic analysis., PMID:39396083
Apoptotic endonuclease EndoG induces alternative splicing of Caspase-2., PMID:39239896
Diagnostic and Predictive Value of LncRNA MCM3AP-AS1 in Sepsis and Its Regulatory Role in Sepsis-Induced Myocardial Dysfunction., PMID:39085530
Mesenchymal Stem Cell-Loaded Hydrogel Improves Surgical Treatment for Chronic Cerebral Ischemia., PMID:38977638
18‑α‑glycyrrhetinic acid induces apoptosis in gingival fibroblasts exposed to phenytoin., PMID:38868612
Characterization of the Apoptotic and Antimicrobial Activities of Two Initiator Caspases of Sea Cucumber Apostichopus japonicus., PMID:38790170
Chemoproteomics Identifies State-Dependent and Proteoform-Selective Caspase-2 Inhibitors., PMID:38787738
Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation., PMID:38676703
A novel TCGA-validated programmed cell-death-related signature of ovarian cancer., PMID:38654239
The knockdown of stathmin with si-RNA inhibits invasion of mesothelioma., PMID:38244401
Bi-allelic truncating variants in CASP2 underlie a neurodevelopmental disorder with lissencephaly., PMID:37880421
A Cell-Penetrant Peptide Disrupting the Transcription Factor CP2c Complexes Induces Cancer-Specific Synthetic Lethality., PMID:37845006
An electrophilic fragment screening for the development of small molecules targeting caspase-2., PMID:37453329
BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors., PMID:37443114
[Overexpression of miR-431-5p impairs mitochondrial function and induces apoptosis in gastric cancer cells via the Bax/Bcl-2/caspase3 pathway]., PMID:37202188
Impacts of potential anticancer agents based on pillar[5]arene for head and neck squamous cell carcinoma cells., PMID:37126106
The Role of Apoptotic Genes and Protein-Protein Interactions in Triple-negative Breast Cancer., PMID:37093683
Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation., PMID:37086756
Chronic exposure to a mixture of phthalates shifts the white and brown adipose tissue phenotypes in female mice., PMID:37021957
Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics., PMID:36379916
Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias., PMID:36343883
Cap CASP, not SCAP, to fight steatohepatitis., PMID:36198289
Caspase-2 mRNA levels are not elevated in mild cognitive impairment, Alzheimer's disease, Huntington's disease, or Lewy Body dementia., PMID:36129947
System level modeling and analysis of TNF-α mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets., PMID:36060699
Regulatory Role of miRNAs and lncRNAs in Gout., PMID:35813414
A Quantitative Proteomic Approach Explores the Possible Mechanisms by Which the Small Molecule Stemazole Promotes the Survival of Human Neural Stem Cells., PMID:35741576
Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis., PMID:35642311
Thymoquinone Alterations of the Apoptotic Gene Expressions and Cell Cycle Arrest in Genetically Distinct Triple-Negative Breast Cancer Cells., PMID:35631261
Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy., PMID:35522720
Nuclear respiratory factor 1 transcriptomic signatures as prognostic indicators of recurring aggressive mesenchymal glioblastoma and resistance to therapy in White American females., PMID:35441887
miR-150-3p enhances neuroprotective effects of neural stem cell exosomes after hypoxic-ischemic brain injury by targeting CASP2., PMID:35436510
MiR-17-5p protects neonatal mice from hypoxic-ischemic brain damage by targeting Casp2., PMID:35085690
lncRNA GMDS‑AS1 upregulates IL‑6, TNF‑α and IL‑1β, and induces apoptosis in human monocytic THP‑1 cells via miR‑96‑5p/caspase 2 signaling., PMID:34981821
Knockdown of Golgi Stress-Responsive Caspase-2 Ameliorates HLD17-Associated AIMP2 Mutant-Mediated Inhibition of Oligodendroglial Cell Morphological Differentiation., PMID:34523057
PROFICS: A bacterial selection system for directed evolution of proteases., PMID:34418435
miR-2 contributes to WSSV infection by targeting Caspase 2 in mud crab (Scylla paramamosain)., PMID:34358576
Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition., PMID:34052187
Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis., PMID:33999360
Caspase-2 as a master regulator of genomic stability., PMID:33752921
Cluster of differentiation 147 (CD147) expression is linked with thiram induced chondrocyte's apoptosis via Bcl-2/Bax/Caspase-3 signalling in tibial growth plate under chlorogenic acid repercussion., PMID:33647747
For research use only. Not for human or drug use.
