Catalog No.
YHE31501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln131-Ser330
Predicted molecular weight
24.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P41235
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nuclear receptor subfamily 2 group A member 1, HNF-4-alpha, HNF4A, Hepatocyte nuclear factor 4-alpha, NR2A1, TCF14, Transcription factor 14, Transcription factor HNF-4, TCF-14, HNF4
Bioinformatics analysis of hub genes and oxidative stress-related pathways in odontogenic keratocysts., PMID:40505773
Uncovering candidate Nanog-Helper genes in early mouse embryo differentiation using differential entropy and network inference., PMID:40481039
Decoding the mystery between hyperuricemia and atrial fibrillation: new causal links through mediating proteomics., PMID:40469443
HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes., PMID:40459008
HNF4α-Mediated LINC02560 Promotes Papillary Thyroid Carcinoma Progression by Targeting the miR-505-5p/PDE4C Axis., PMID:40427523
Differing MODY subtypes in a single family: A case report on monogenic diabetes, a CARE-compliant article., PMID:40419889
HNF4A Regulated APEH Deficiency Promotes UPR Activation in Diabetic Kidney Disease., PMID:40396970
Hepatocyte Nuclear Factor 4 Alpha: A Key Regulator of Liver Disease Pathology and Haemostatic Disorders., PMID:40387433
Impact of cardiosphere-derived cells on the maladapted right ventricular muscle in a rat sugen/hypoxia model of pulmonary hypertension with right ventricular dysfunction., PMID:40354360
A First-in-Class Hepatocyte Nuclear Factor 4 Agonist., PMID:40336482
Transcriptional Regulators in the Cerebellum in Chronic Schizophrenia: Novel Possible Targets for Pharmacological Interventions., PMID:40332239
Oncogenic HNF4α inhibits ferroptotic cell death through activating SLC7A11 by recruiting p300/CBP in breast cancer., PMID:40320185
Melatonin partially restores hepatic nocturnin oscillations in experimental models of MASLD., PMID:40313203
Focusing on Rare Variants Related to Maturity-Onset Diabetes of the Young in Children., PMID:40303944
Non-surgical Treatment May be Appropriate for Most Chinese Children With Monogenic Congenital Hyperinsulinism Based on a Retrospective Study of 121 Patients., PMID:40302972
Neonatal hypoglycaemia in the offsprings of parents with maturity-onset diabetes of the young (MODY)., PMID:40287849
Dual Role of HNF4α in Colorectal Adenocarcinoma During Carcinogenesis and Metastasis., PMID:40277924
Clinicopathological characteristics of transcription factor-defined subtypes in bladder small cell carcinoma., PMID:40275187
GLP-1 RA and dual GIP/GLP-1 RA treatment in MODY: a descriptive case series., PMID:40274278
HNF4A functions as a hepatocellular carcinoma oncogene or tumor suppressor depending upon the AMPK pathway activity status., PMID:40254090
Systemic genome-epigenome analysis captures a lineage-specific super-enhancer for MYB in gastrointestinal adenocarcinoma., PMID:40234694
Single-cell transcriptomics reveals liver developmental trajectory during lineage reprogramming of human induced hepatocyte-like cells., PMID:40188417
MYCBP2-mediated HNF4α ubiquitination reprogrammed lipid metabolism in MASH-associated hepatocellular carcinoma., PMID:40181155
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn's disease-like ileitis., PMID:40117343
Wogonoside ameliorates oxidative damage in tubular epithelial cells of diabetic nephropathy by modulating the HNF4A-NRF2 axis., PMID:40086061
Hepatic progenitor cells reprogrammed from mouse fibroblasts repopulate hepatocytes in Wilson's disease mice., PMID:40069754
Comparative Evaluation and Profiling of Chemical Tools for the Nuclear Hormone Receptor Family 2., PMID:40046426
Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity., PMID:40037142
Novel Function of NUP153 in HNF4α Transcriptional Upregulation Contributes to Promoting HBV Replication., PMID:40014546
Distinct roles of Constitutive Photomorphogenesis Protein 1 homolog (COP1) in human hepatocyte models., PMID:39990870
HNF4A mitigates sepsis-associated lung injury by upregulating NCOR2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype., PMID:39979267
An Asian monogenic diabetes registry: prevalence, long-term renal trajectory and development of a diagnostic algorithm for selection of candidates for genetic testing., PMID:39963770
Liver-specific glucocorticoid action in alcoholic liver disease: Study of glucocorticoid receptor knockout and knockin mice., PMID:39959874
Injured Proximal Tubular Epithelial Cells Lose Hepatocyte Nuclear Factor 4α Expression Crucial for Brush Border Formation and Transport., PMID:39954965
Hypoxia reduces SLC27A5 to promote hepatocellular carcinoma proliferation by repressing HNF4A., PMID:39938688
Current views on etiology, diagnosis, epidemiology and gene therapy of maturity onset diabetes in the young., PMID:39902162
Early tolerance and late persistence as alternative drug responses in cancer., PMID:39900637
Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis., PMID:39899681
Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes., PMID:39878507
Genetic Structure of Hereditary Forms of Diabetes Mellitus in Russia., PMID:39859454
Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis., PMID:39843425
Therapeutic insight into the role of nuclear protein HNF4α in liver carcinogenesis., PMID:39843133
Hepatocyte nuclear factor 4α as a sensitive marker for uterine endocervical adenocarcinomas and their precursors., PMID:39798855
Exploring the molecular mechanisms of tirzepatide in alleviating metabolic dysfunction-associated fatty liver in mice through integration of metabolomics, lipidomics, and proteomics., PMID:39794823
Hepatocyte nuclear factor 4-α is necessary for high fat diet-induced pancreatic β-cell mass expansion and metabolic compensations., PMID:39741884
Hepatocyte-Derived FGF1 Alleviates Isoniazid and Rifampicin-Induced Liver Injury by Regulating HNF4α-Mediated Bile Acids Synthesis., PMID:39731358
Antiviral activity of HuaganJiedu decoction (HGJDD) against hepatitis B virus (HBV) through FOXO4/ERK/HNF4α signal pathway., PMID:39701219
Plastic additives affect estrogenic pathways and lipid metabolism in precision - cut - liver slices in Atlantic cod (Gadus morhua)., PMID:39689470
Human liver organoids are susceptible to Plasmodium vivax infection., PMID:39639330
Decreased lncRNA HNF4A-AS1 facilitates resistance to sorafenib-induced ferroptosis of hepatocellular carcinoma by reprogramming lipid metabolism., PMID:39629121
For research use only. Not for human or drug use.
