Catalog No.
YHE27601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln407-Cys756
Predicted molecular weight
42.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P40692
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
COCA2, DNA mismatch repair protein Mlh1, MutL protein homolog 1, MLH1
T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes., PMID:40490584
Clinicopathological Characteristics of Upper Tract Urothelial Cancer With Loss of Immunohistochemical Expression of Mismatch Repair Proteins., PMID:40488817
Fusobacterium nucleatum downregulated MLH1 expression in colorectal cancer by activating autophagy-lysosome pathway., PMID:40458404
Biological characteristics of spontaneous ovarian cancer in Microtusfortis., PMID:40457786
Mismatch Repair Proteins Immunostaining in Lip Squamous Cell Carcinoma: A Role in Lip Carcinogenesis?, PMID:40439366
Screening of biobank SNP-array genotyping data to detect Lynch syndrome predisposing MLH1 copy number variants., PMID:40418428
Microsatellite instability and mismatch repair deficiency in bladder urothelial carcinoma: a Tunisian single-center study., PMID:40415014
[A Case of Successful Combination of Immune Checkpoint Inhibitors and Radiotherapy for MLH1 Gene-Deficient Colon Cancer]., PMID:40360414
Pathogenic germline variants in mismatch repair genes in patients with microsatellite instability-high gastric cancer., PMID:40353075
Gastrointestinal Amphicrine Carcinoma: A Clinicopathologic Study of Five Patients., PMID:40350569
Exploring the promoter regions of cancer predisposition genes in patients with triple-negative breast cancer reveals the presence of rare germline variants., PMID:40338220
A phase 2 trial of pembrolizumab for recurrent Lynch-like versus sporadic endometrial cancers with microsatellite instability (NCT02899793): Updated survival and response analyses., PMID:40334308
EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA., PMID:40319035
Identification of non-synonymous SNPs affecting structure and function of MLH1 and NBN proteins: a computational approach., PMID:40312597
Correlation between Isocitrate Dehydrogenase Mutation and Immunohistochemical Expression of DNA Mismatch Repair Proteins in the Prognosis of Gliomas., PMID:40302099
The role of MLH1, MSH2 and MSH6 in the development of colorectal cancer in Uganda., PMID:40295928
Disentangling the mutational effects on protein stability and interaction of human MLH1., PMID:40294053
Identification of genomic variants associated with colorectal cancer heredity in indigenous populations of the Amazon., PMID:40287430
Microsatellite Status, Tumor Budding, CD3 and CD8 T Cell Densities in Relation to Invasiveness, Lymph Node Involvement in Colorectal Adenocarcinoma., PMID:40263681
The Clinical Outcomes Among Patients Under 60 Years Old with Lynch Syndrome: Variations Based on Different Mutation Patterns., PMID:40244260
Germline variants in patients from the Iranian hereditary colorectal cancer registry., PMID:40223084
Pathological complete response following addition of durvalumab to gemcitabine and cisplatin therapy for intrahepatic cholangiocarcinoma with Lynch syndrome-associated mismatch repair deficiency., PMID:40210796
It's prime time for multiplexed prime editing., PMID:40209678
Causes of DNA mismatch repair deficiency in sebaceous skin lesions demonstrating loss of MLH1 protein expression: constitutional over somatic MLH1 promoter methylation., PMID:40208414
Pulmonary Tumor Thrombotic Microangiopathy Associated With Gastric Cancer: Clinical Characteristics and Outcomes., PMID:40200872
Constitutional Epimutations: From Rare Events Toward Major Cancer Risk Factors?, PMID:40179326
Coexisting germline variants of MLH1 and MSH6 in a patient with Lynch syndrome who had uterine and ovarian cancer., PMID:40160885
Analyzing pathogenic variants in mismatch repair genes: personalized prevention strategies for lynch syndrome in Chinese families., PMID:40160320
High-throughput screening of human genetic variants by pooled prime editing., PMID:40120586
Study on the Application of MLPA Detection for Large Fragment Loss of Mismatch Repair Genes in Chinese HNPCC Families., PMID:40116103
Prevalence of Mismatch Repair Deficiency in Primary Prostate Cancer in a Large Prospective Cohort., PMID:40105779
Genetic dissection of MutL complexes in Arabidopsis meiosis., PMID:40105242
MutLγ enforces meiotic crossovers in Arabidopsis thaliana., PMID:40105241
MMR deficiency is frequent in colorectal carcinomas with diffuse SLFN11 immunostaining: clinicopathologic and molecular study of 31 cases identified among 3,300 tumors., PMID:40105034
[Sessile serrated lesion with dysplasia and invasion]., PMID:40089942
Novel De Novo BRCA2 Variant in an Early-Onset Ovarian Cancer Reveals a Unique Tumor Evolution Pathway., PMID:40076915
Rare pathogenic structural variants show potential to enhance prostate cancer germline testing for African men., PMID:40064858
Are all mismatch repair deficient endometrial cancers created equal? A large, retrospective, tertiary center experience., PMID:40058269
Microsatellite-high intrahepatic cholangiocarcinoma with favorable treatment outcome using pembrolizumab., PMID:40032770
[Advances in constitutional mismatch repair deficiency syndrome associated tumors]., PMID:40032429
A case of multiple advanced colon cancers with spontaneous regression of only one lesion after biopsy: a case report and literature review., PMID:40029573
Identification of Schizophrenia-Risk Regulatory Variant rs1399178 in the Non-coding Region With Its Impact on NRF1 Binding., PMID:40019038
Obesity correlates to the microsatellite instability of endometrial cancer: A retrospective observational study., PMID:40009888
MLH1 Methylation Status and Microsatellite Instability in Patients with Colorectal Cancer., PMID:40004511
Integrated Analysis of Somatic DNA Variants and DNA Methylation of Tumor Suppressor Genes in Colorectal Cancer., PMID:40004106
Development of Syngeneic Murine Glioma Models with Somatic Mismatch Repair Deficiency to Study Therapeutic Responses to Alkylating Agents and Immunotherapy., PMID:39995104
Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1., PMID:39981936
Clinicopathological and Immunohistochemical Risk Predictors for Ameloblastoma Recurrence., PMID:39960551
MLH1 and MSH2 expression in endometrial cancer - microscopic and computer assessment of immunohistochemical method., PMID:39949324
[A Case of Lynch Syndrome with MSH2 Likely Pathogenic Variant Who Developed Rectal Cancer Due to Methylation of MLH1]., PMID:39948959
For research use only. Not for human or drug use.
