Catalog No.
YHE23501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Pro164
Predicted molecular weight
20.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P38936
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CDKN1, MDA-6, Cyclin-dependent kinase inhibitor 1, CIP1, WAF1, CDKN1A, p21, PIC1, Melanoma differentiation-associated protein 6, MDA6, SDI1, CDK-interacting protein 1, CAP20
Tumor-derived CXCL5 promotes 5-fluorouracil resistance in colorectal cancer cells via p21 downregulation., PMID:40514583
DNA damage response inhibition is an early event in cadmium-induced breast carcinogenesis., PMID:40505819
Transglutaminase 2-mediated glutamine deamidation enhances p21 stability during senescence., PMID:40498452
Infrared-A (IR-A) modulates the p53 pathway and diurnal clock in human skin and subcutaneous adipose tissue in vivo., PMID:40482318
A hormone-dependent tRNA half promotes cell cycle progression via destabilization of p21 mRNA., PMID:40471969
Reshaping the landscape of locoregional treatments for breast cancer liver metastases: A novel, intratumoral, p21-targeted percutaneous therapy increases survival in BALB/c mice inoculated with 4T1 triple negative breast cancer cells in the liver., PMID:40471957
Alcohol, Anti-HIV Drugs, and/or Hippuric Acid Deteriorate Cellular Stresses in Senescent Hepatocytes and Aging Murine Liver., PMID:40463894
Effects of kidney-tonifying Chinese herbs on thymus regen-eration after rapamycin-induced degeneration in mice., PMID:40461290
[Mechanism of matrine against senescence in human umbilical vein endothelial cells based on network pharmacology and experimental verification]., PMID:40461235
MitoQ for vitiligo by mitigating PARP1 translocation aberrations: Network pharmacology and experimental validation., PMID:40451398
BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress., PMID:40436896
Key Ferroptosis Genes and their Predictive and Diagnostic Value in Fanconi Anemia., PMID:40432442
Efficacy, safety and exploratory analysis of neoadjuvant tislelizumab (a PD-1 inhibitor) plus nab-paclitaxel followed by epirubicin/cyclophosphamide for triple-negative breast cancer: a phase 2 TREND trial., PMID:40414961
CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH., PMID:40414463
Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells., PMID:40409732
Repurposing HIV protease inhibitors as senotherapeutic agents in cervical cancer: Dual targeting of CDK1/6-cell cycle arrest and p53/p21/p16 signaling axis., PMID:40403681
Kisspeptin-10 Protects Against TNF-α-Induced Chondrocyte Senescence via the SIRT1/p53/p21 Signaling., PMID:40400312
Tertiary Lymphoid Structures as Independent Predictors of Favorable Prognosis in Muscle-Invasive Bladder Cancer., PMID:40396416
Extreme multivalency and a composite short linear motif facilitate PCNA-binding, localisation and abundance of p21 (CDKN1A)., PMID:40392971
The Genetic Association between CDKN1A and Heart Failure: Genome-Wide Exploration of m 6A-SNPs and Mendelian Randomization., PMID:40383946
Stereoisomeric mitomycins interstrand crosslinks differently impact gene expression in MCF-7 and K562 cancer cells., PMID:40383468
Glucosylated cholesterol accumulates in atherosclerotic lesions and impacts macrophage immune response., PMID:40381699
Atf3 + senescent chondrocytes mediate meniscus degeneration in aging., PMID:40375324
Inorganic Arsenic Induces Elevated p53 Levels with Altered Functionality Impacting the Expression of Toll-like Receptor 3 and Other Target Genes in Immortalized Prostate Epithelial Cells., PMID:40362489
p21-Dependent Senescence Induction by BMP4 Renders Glioblastoma Cells Vulnerable to Senolytics., PMID:40362216
Characterization of Two Stable Biodosimeters for Absorbed Ionizing Radiation Dose Estimation in Multiple Combined Injury Models., PMID:40360172
Ethanol extract from Ziziphus nummularia stem inhibits MCF-7 breast cancer cell proliferation through TP53 regulating kinase (TP53RK)-mediated p53 activation: In silico and genes expression investigations., PMID:40352177
[Guiqi Yiyuan Ointment combined with cisplatin inhibits tumor growth in Lewis lung carcinoma-bearing mice by regulating PERK/eIF2α/ATF4/CHOP signaling pathway]., PMID:40350946
[Mechanism of Qitu Erzhi Decoction against chemotherapy-induced myelosuppression based on network pharmacology and experimental validation]., PMID:40350848
Proanthocyanidins delaying the premature ovarian insufficiency through regulatory sirt1-p53-p21 signaling pathway in female germline stem cells., PMID:40349064
RNA demethylase ALKBH5 regulates cell cycle progression in DNA damage response., PMID:40341728
Neonatal exposure to an environmentally relevant phthalate mixture alters ovarian function in mice., PMID:40328337
Downregulation of EZH2 Promotes Renal Epithelial Cellular Senescence and Kidney Aging., PMID:40326780
ZNF224 enhances the oncogenic function of p21 via p53 and AKT pathways in melanoma., PMID:40321146
Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways., PMID:40319296
Therapy-induced senescence of glioblastoma cells is determined by the p21CIP1-CDK1/2 axis and does not require activation of DREAM., PMID:40319068
Combination therapy of adagrasib and abemaciclib in non-small cell lung cancer brain metastasis models genomically characterized by KRAS-G12C and homozygous loss of CDKN2A., PMID:40317086
Phase separation of MRG15 delays cellular senescence., PMID:40312521
Design, synthesis, and biological evaluation of novel CDK4/6 and BRD4 dual inhibitors for treatment of KRAS-mutant NSCLC., PMID:40311163
Cdkn1a silencing restores myoblast differentiation by inducing selective apoptosis in senescent cells., PMID:40307745
Cell cycle duration determines oncogenic transformation capacity., PMID:40307557
Lower levels of senescence in human lung mesenchymal stromal cells compared with lung fibroblasts: implications for tissue regeneration in COPD., PMID:40304287
FOXG1 Improves Cognitive Function in Alzheimer's Disease by Promoting Endogenous Neurogenesis., PMID:40297942
[High expression of CDKN3 promotes migration and invasion of gastric cancer cells by regulating the p53/NF-κB signaling pathway and inhibiting cell apoptosis]., PMID:40294936
KRIBB11 Exerts Anticancer Effects on A172 Glioblastoma Cells via the Cdh1/SKP2/p27 and HSF1/p53/p21 Pathways., PMID:40280718
CDK5 targets p21CIP1 to regulate thyroid cancer cell proliferation and malignancy in patients., PMID:40280108
Accelerated senescence of bone marrow erythrocyte precursors in myelodysplastic syndrome., PMID:40277030
27-hydroxycholesterol impairs placental development via p53/p21/Cdk6 pathway: Implications for nutrient transport and cellular senescence., PMID:40268063
To establish and validate autophagy related biomarkers for the diagnosis of IgA nephropathy., PMID:40263537
Aptamer selection of radiation-sensitive protein p21 and electrical impedance detection-based applications in radiation dose assessment., PMID:40253803
For research use only. Not for human or drug use.
