Catalog No.
YHE20801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr112-Thr543
Predicted molecular weight
52.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P37088
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ENaCA, SCNN1A, Epithelial Na(+) channel subunit alpha, SCNEA, SCNN1, Alpha-NaCH, Amiloride-sensitive sodium channel subunit alpha, Nonvoltage-gated sodium channel 1 subunit alpha, Alpha-ENaC
Amiloride synergizes with EGFR PROTACs and inhibitors to overcome therapeutic resistance in NSCLC., PMID:40489919
Stable overexpression of the epithelial sodium channel alpha subunit reduces migration and proliferation in breast cancer cells., PMID:40220219
Downregulation of the Unfolded Protein Response Links Metformin Treatment to Good Clinical Outcomes in Colorectal Cancer Patients., PMID:40136342
The evolutionary path of the epithelial sodium channel δ-subunit in Cetartiodactyla points to a role in sodium sensing., PMID:39605611
Response of Blood Pressure to Renal Denervation Is Not Associated With Genetic Variants., PMID:39569514
Taurine is essential for mouse uterine luminal fluid resorption during implantation window via the SCNN1A and AQP8 signaling†., PMID:39428112
Pulmonary manifestations of Pseudohypoaldosteronism type 1b: A systematic review of the literature., PMID:39419738
Liddle Syndrome with a SCNN1A Mutation: A Case Report and Literature Review., PMID:39236685
Differential expression of ion channel coding genes in the endometrium of women experiencing recurrent implantation failures., PMID:39192025
The epithelial Na+ channel (ENaC) in ovarian granulosa cells modulates Ca2+ mobilization and gonadotrophin signaling for estrogen homeostasis and female fertility., PMID:39143495
Novel homozygous mutation in SCNN1A gene in an Iranian boy with PHA1B., PMID:38963175
An unusual case of Pseudohypoaldosteronism coexisting with cystic fibrosis., PMID:38914525
Upregulation of α-ENaC induces pancreatic β-cell dysfunction, ER stress, and SIRT2 degradation., PMID:38769731
Comprehensive mapping of Epithelial Na+ channel α expression in the mouse brain., PMID:38305875
A frameshift mutation in the SCNN1B gene in a family with Liddle syndrome: A case report and systematic review., PMID:38099339
Association between low-sodium salt intervention and long-term blood pressure changes is modified by ENaC genetic variation: a gene-diet interaction analysis in a randomized controlled trial., PMID:37843257
Identification of Proteins Involved in Cell Membrane Permeabilization by Nanosecond Electric Pulses (nsEP)., PMID:37298142
Exploring the shared gene signatures of smoking-related osteoporosis and chronic obstructive pulmonary disease using machine learning algorithms., PMID:37251077
A mild and transient form of autosomal recessive pseudohypoaldosteronism type 1 caused by a novel mutation in the SCNN1A gene., PMID:37134141
Inactivation of epithelial sodium ion channel molecules serves as effective diagnostic biomarkers in clear cell renal cell carcinoma., PMID:37133722
A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells., PMID:37045597
Lipid metabolism-related miRNAs with potential diagnostic roles in prostate cancer., PMID:36915125
Hormonal regulation of non-cystic fibrosis transmembrane conductance regulator ion channels in the endocervix., PMID:36907435
Single-nucleus RNA and ATAC sequencing uncovers the molecular and cellular characteristics in the musk gland of Chinese forest musk deer (Moschus berezovskii)., PMID:36583723
Clinical and genetic characteristics of the patients with hypertension and hypokalemia carrying a novel SCNN1A mutation., PMID:36336351
Rare Variants in Genes Encoding Subunits of the Epithelial Na+ Channel Are Associated With Blood Pressure and Kidney Function., PMID:36193739
A Selective Histone Deacetylase Inhibitor Induces Autophagy and Cell Death via SCNN1A Downregulation in Glioblastoma Cells., PMID:36139696
Sodium channel 1 subunit alpha SCNN1A exerts oncogenic function in pancreatic cancer via accelerating cellular growth and metastasis., PMID:35714697
Decoding a gene expression program that accompanies the phenotype of sporadic and basal cell nevus syndrome-associated odontogenic keratocyst., PMID:35665542
A Family with Liddle Syndrome Caused by a Novel Stop-Gain Mutation in the γ Subunit of Epithelial Sodium Channels., PMID:35661050
Downregulation of epithelial sodium channel (ENaC) activity in cystic fibrosis cells by epigenetic targeting., PMID:35462606
Accessibility of ENaC extracellular domain central core residues., PMID:35339489
Swelling-induced upregulation of miR-141-3p inhibits hepatocyte proliferation., PMID:35287291
A Rare Case of Familiar Hypertension Presenting with Hypertensive Encephalopathy in an Elderly Patient: A Diagnostic Dilemma: A Presentation of Liddle's Syndrome due to Novel Mutation in SCNN1G Gene., PMID:35229818
Chronic Systemic Dexamethasone Regulates the Mineralocorticoid/Glucocorticoid Pathways Balance in Rat Ocular Tissues., PMID:35163201
Identification of the pivotal role of SPP1 in kidney stone disease based on multiple bioinformatics analysis., PMID:35016690
Tempol Alters Urinary Extracellular Vesicle Lipid Content and Release While Reducing Blood Pressure during the Development of Salt-Sensitive Hypertension., PMID:34944449
Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer., PMID:34823420
Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension., PMID:34714114
Salt-Sensitive Hypertension of the Renal Tubular Cell-Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice., PMID:34601973
HOXD9‑induced SCNN1A upregulation promotes pancreatic cancer cell proliferation, migration and predicts prognosis by regulating epithelial‑mesenchymal transformation., PMID:34558641
A novel nonsense mutation in the β-subunit of the epithelial sodium channel causing Liddle syndrome., PMID:34223773
Fluoride effects on cell viability and ENaC expression in kidney epithelial cells., PMID:34151709
Novel SCNN1A gene splicing-site mutation causing autosomal recessive pseudohypoaldosteronism type 1 (PHA1) in two Italian patients belonging to the same small town., PMID:34134742
DNA Methylation Patterns Correlate with the Expression of SCNN1A, SCNN1B, and SCNN1G (Epithelial Sodium Channel, ENaC) Genes., PMID:33916525
Molecular regulation of lung maturation in near-term fetal sheep by maternal daily vitamin C treatment in late gestation., PMID:33859366
A Novel SCNN1A Variation in a Patient with Autosomal-recessive Pseudohypoaldosteronism Type 1., PMID:33829730
Extracellular vesicles regulate purinergic signaling and epithelial sodium channel expression in renal collecting duct cells., PMID:33811695
Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus., PMID:33727367
Clinical characteristics and treatment requirements of children with autosomal recessive pseudohypoaldosteronism., PMID:33690157
For research use only. Not for human or drug use.
