Catalog No.
YHE19201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln24-Arg152
Predicted molecular weight
16.50 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P36894
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ACVRLK3, Bone morphogenetic protein receptor type-1A, ALK3, BMPR-1A, Serine/threonine-protein kinase receptor R5, SKR5, Activin receptor-like kinase 3, ALK-3, BMP type-1A receptor, BMPR1A, CD292
A Novel Missense Variant of BMPR1A in Juvenile Polyposis Syndrome: Assessment of Structural and Functional Alternations., PMID:40226309
GDF15 promotes trophoblast invasion and pregnancy success via the BMPR1A/BMPR2/p-SMAD1 pathway: Implications for recurrent miscarriage., PMID:40157640
Successful treatment of juvenile polyposis of infancy with sirolimus: a case report., PMID:39180038
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway., PMID:38913236
Juvenile polyposis syndrome in children: The impact of SMAD4 and BMPR1A mutations on clinical phenotype and polyp burden., PMID:38801072
ZEB1-AS1 mediates bone metastasis through targeting miR-320b/BMPR1A axis in lung cancer., PMID:38783645
Deciphering the clinical spectrum of gastric disease in patients with juvenile polyposis syndrome., PMID:38777277
SMAD4 mosaicism in juvenile polyposis: Essential contribution of somatic analysis in diagnosis., PMID:38695688
Silibinin is a suppressor of the metastasis-promoting transcription factor ID3., PMID:38484626
Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma., PMID:38446374
GALNT12 suppresses the bone-specific prostate cancer metastasis by activating BMP pathway via the O-glycosylation of BMPR1A., PMID:38385080
Nonsense suppression induces read-through of a novel BMPR1A variant in a Chinese family with hereditary colorectal cancer., PMID:38192234
Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study., PMID:37485765
Diffuse Hamartomatous Change in the Gallbladder of a Patient With Deletion Involving PTEN and BMPR1A Genes., PMID:37252796
Adenomatous Polyposis Phenotype in BMPR1A and SMAD4 Variant Carriers., PMID:36049049
Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation., PMID:35842443
BMP7-based peptide agonists of BMPR1A protect the left ventricle against pathological remodeling induced by pressure overload., PMID:35616049
Exosomal miR-143-3p derived from follicular fluid promotes granulosa cell apoptosis by targeting BMPR1A in polycystic ovary syndrome., PMID:35288625
The LPS induced pyroptosis exacerbates BMPR2 signaling deficiency to potentiate SLE-PAH., PMID:34818449
Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERα levels., PMID:34743989
A novel BMPR1A mutation affects mRNA splicing in juvenile polyposis syndrome., PMID:34699658
Lethal variants in humans: lessons learned from a large molecular autopsy cohort., PMID:34645488
Bone morphogenetic protein receptor 2 inhibition destabilizes microtubules promoting the activation of lysosomes and cell death of lung cancer cells., PMID:34563224
BMP-4 Extraction from Extracellular Matrix and Analysis of Heparin-Binding Properties., PMID:34550550
Bioactive Lipid O-cyclic phytosphingosine-1-phosphate Promotes Differentiation of Human Embryonic Stem Cells into Cardiomyocytes via ALK3/BMPR Signaling., PMID:34209900
Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival., PMID:34013359
mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion., PMID:33822054
Bone morphogenetic protein signaling regulates skin inflammation via modulating dendritic cell function., PMID:33250156
Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant., PMID:33097490
Familial juvenile polyposis syndrome with a de novo germline missense variant in BMPR1A gene: a case report., PMID:33032550
Aberrant BMP2 Signaling in Patients Diagnosed with Osteoporosis., PMID:32967078
Cancer within the family tree: risks, diagnosis and treatment of juvenile polyposis syndrome., PMID:32816937
BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation., PMID:32764110
Updates in the field of hereditary nonpolyposis colorectal cancer., PMID:32755332
Juvenile polyposis syndrome might be misdiagnosed as familial adenomatous polyposis: a case report and literature review., PMID:32487124
Disease expression in juvenile polyposis syndrome: a retrospective survey on a cohort of 221 European patients and comparison with a literature-derived cohort of 473 SMAD4/BMPR1A pathogenic variant carriers., PMID:32398773
A novel germline BMPR1A variant (c.72_73delGA) in a Japanese family with hereditary mixed polyposis syndrome., PMID:32378721
Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche., PMID:32354994
Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles., PMID:32217638
BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency., PMID:31769494
Patients with 10q22.3q23.1 recurrent deletion syndrome are at risk for juvenile polyposis., PMID:31561016
Homozygous missense variant in BMPR1A resulting in BMPR signaling disruption and syndromic features., PMID:31493347
LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling., PMID:31334575
Variable Features of Juvenile Polyposis Syndrome With Gastric Involvement Among Patients With a Large Genomic Deletion of BMPR1A., PMID:31259752
BMPR1A mutation-positive juvenile polyposis syndrome and atrial septal defect: coincidence or association?, PMID:31229977
Mechanism of CK2.3, a Novel Mimetic Peptide of Bone Morphogenetic Protein Receptor Type IA, Mediated Osteogenesis., PMID:31117181
Looking for the hidden mutation: Bannayan-Riley-Ruvalcaba syndrome caused by constitutional and mosaic 10q23 microdeletions involving PTEN and BMPR1A., PMID:31062505
Assessment of structurally and functionally high-risk nsSNPs impacts on human bone morphogenetic protein receptor type IA (BMPR1A) by computational approach., PMID:30884445
A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A., PMID:30814609
Gastrointestinal juvenile-like (inflammatory/hyperplastic) mucosal polyps in neurofibromatosis type 1 with no concurrent genetic or clinical evidence of other syndromes., PMID:30276464
For research use only. Not for human or drug use.
