Catalog No.
YHE17201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr227-Val358
Predicted molecular weight
17.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P36382
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cx40, Gap junction alpha-5 protein, Connexin-40, GJA5
Mitochondrial damage mediates STING activation driving obesity-mediated atrial fibrillation., PMID:40186485
Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers., PMID:39819837
VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17., PMID:39354506
Distribution characteristics of Purkinje fibres in the canine left ventricle., PMID:39320327
Cx40 Levels Regulate Hypoxia-Induced Changes in the Migration, Proliferation, and Formation of Gap Junction Plaques in an Extravillous Trophoblast Cell Model., PMID:38995001
Human Genetics of Ventricular Septal Defect., PMID:38884729
Ibrutinib Contributes to Atrial Arrhythmia through the Autophagic Degradation of Connexins by Inhibiting the PI3K-AKT-mTOR Signaling Pathway., PMID:38812314
Decreased connexin 40 expression of the sinoatrial node mediates ischemic stroke-induced arrhythmia in mice., PMID:38599368
[Analysis of clinical characteristics and molecular genetics in eighteen patients with 1q21.1 microdeletion syndrome]., PMID:38565516
Identification and validation of a gap junction protein related signature for predicting the prognosis of renal clear cell carcinoma., PMID:38454924
Capillary oxygen regulates demand-supply coupling by triggering connexin40-mediated conduction: Rethinking the metabolic hypothesis., PMID:38349880
Construction of a 5-gene prognostic signature based on oxidative stress related genes for predicting prognosis in osteosarcoma., PMID:38039294
DNMT1-mediated NR3C1 DNA methylation enables transcription activation of connexin40 and augments angiogenesis during colorectal cancer progression., PMID:37813207
A radiomics signature associated with underlying gene expression pattern for the prediction of prognosis and treatment response in hepatocellular carcinoma., PMID:37708675
[Overexpression of connexin 40 (Cx40) inhibits the proliferation of H9c2 cardiomyocytes in rats by cell cycle arrest]., PMID:37515338
Association between polymorphisms in connexin 40 gene (Cx40) and risk of atrial fibrillation: a meta-analysis based on 3,452 subjects., PMID:37382580
Connexin 40-Mediated Regulation of Systemic Circulation and Arterial Blood Pressure., PMID:37331352
Galectin-1 Regulates RNA Expression and Alternative Splicing of Angiogenic Genes in HUVECs., PMID:37114537
Evidence for selective sweeps in the MHC gene repertoire of various cattle breeds., PMID:37039747
A novel GJA5 variant associated with increased risk of essential hypertension., PMID:36915790
The Role of TRPM4 Gene Mutations in Causing Familial Progressive Cardiac Conduction Disease: A Further Contribution., PMID:35205305
Cx43 carboxyl terminal domain determines AQP4 and Cx30 endfoot organization and blood brain barrier permeability., PMID:34934080
Single-cell RNA sequencing of mouse left ventricle reveals cellular diversity and intercommunication., PMID:34859688
Cis-acting mutation affecting GJA5 transcription is underlying the Melanotic within-feather pigmentation pattern in chickens., PMID:34607956
Novel Serum Biomarkers of Neurovascular Unit Associated with Cortical Amyloid Deposition., PMID:34602488
Xanthine oxidase inhibitor febuxostat reduces atrial fibrillation susceptibility by inhibition of oxidized CaMKII in Dahl salt-sensitive rats., PMID:34386810
Calcium Signal Profiles in Vascular Endothelium from Cdh5-GCaMP8 and Cx40-GCaMP2 Mice., PMID:33706307
The novel ginsenoside AD2 prevents angiotensin II-induced connexin 40 and connexin 43 dysregulation by activating AMP kinase signaling in perfused beating rat atria., PMID:33676887
A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes., PMID:33664309
Alteration of Cx37, Cx40, Cx43, Cx45, Panx1, and Renin Expression Patterns in Postnatal Kidneys of Dab1-/- (yotari) Mice., PMID:33525532
BIRC5, GAJ5, and lncRNA NPHP3-AS1 Are Correlated with the Development of Atrial Fibrillation-Valvular Heart Disease., PMID:33518654
Chronic Hypoxia Decreases Endothelial Connexin 40, Attenuates Endothelium-Dependent Hyperpolarization-Mediated Relaxation in Small Distal Pulmonary Arteries, and Leads to Pulmonary Hypertension., PMID:33307937
Structural, Pro-Inflammatory and Calcium Handling Remodeling Underlies Spontaneous Onset of Paroxysmal Atrial Fibrillation in JDP2-Overexpressing Mice., PMID:33265909
Cardiac Pressure Overload Decreases ETV1 Expression in the Left Atrium, Contributing to Atrial Electrical and Structural Remodeling., PMID:33225722
Connexin Signaling in the Juxtaglomerular Apparatus (JGA) of Developing, Postnatal Healthy and Nephrotic Human Kidneys., PMID:33172216
NOTCH1 is critical for fibroblast-mediated induction of cardiomyocyte specialization into ventricular conduction system-like cells in vitro., PMID:32999360
Electrical stimulation applied during differentiation drives the hiPSC-CMs towards a mature cardiac conduction-like cells., PMID:32962862
Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction., PMID:32898233
Conjugated activation of myocardial-specific transcription of Gja5 by a pair of Nkx2-5-Shox2 co-responsive elements., PMID:32687896
Prolonged duration of repolarization and decreased conduction velocity in the atrial myocardium after hypothermic ischemia-reperfusion may be related to expressions of inward rectifier potassium channel 2.1 protein and connexin 40., PMID:32650696
ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction., PMID:32347164
Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death., PMID:32346730
Vascular smooth muscle cell phenotypic transition regulates gap junctions of cardiomyocyte., PMID:32270355
Systemic therapy in an RNA toxicity mouse model with an antisense oligonucleotide therapy targeting a non-CUG sequence within the DMPK 3'UTR RNA., PMID:32242217
Upregulation of Connexin 40 Mediated by Nitric Oxide Attenuates Cerebral Vasospasm After Subarachnoid Hemorrhage via the Nitric Oxide-Cyclic Guanosine Monophosphate-Protein Kinase G Pathway., PMID:31953101
Intercellular Conduction Optimizes Arterial Network Function and Conserves Blood Flow Homeostasis During Cerebrovascular Challenges., PMID:31826653
Nkx2.5 insufficiency leads to atrial electrical remodeling through Wnt signaling in HL-1 cells., PMID:31798700
Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction., PMID:31778152
Detection of a familial 1q21.1 microdeletion and concomitant CHD1L mutation in a fetus with oligohydramnios and bilateral renal dysplasia on prenatal ultrasound., PMID:31759543
For research use only. Not for human or drug use.
