Catalog No.
YHE14301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly193-Cys444
Predicted molecular weight
27.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35637
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Oncogene TLS, Oncogene FUS, TLS, POMp75, RNA-binding protein FUS, 75 kDa DNA-pairing protein, Translocated in liposarcoma protein, FUS
circLRCH3-FUS interaction stabilizes IFI35 mRNA, inhibiting autophagy and aggravating podocyte pyroptosis in lupus nephritis., PMID:40505228
Protein Pathologies in Oligodendroglia in Neurodegenerative Diseases., PMID:40500505
[Cytokeratin (pan)-positive EWSR1/FUS::CREB fusion malignant tumor in abdominopelvic cavity: a clinicopathological and molecular analysis of four cases]., PMID:40494767
RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights., PMID:40468389
Response of Serum-Isolated Extracellular Vesicles to Focused Ultrasound-Mediated Blood-Brain Barrier Opening., PMID:40450507
circ_0002456/FUS interaction inhibits NF-κB signaling to attenuate DNA damage and inflammatory responses in hDPSCs., PMID:40457486
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy., PMID:40448612
Genetic Basis of Motor Neuron Diseases: Insights, Clinical Management, and Future Directions., PMID:40430041
Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses., PMID:40422183
Establishment and characterization of NCC-MLPS4-C1: a novel patient-derived cell line of myxoid liposarcoma., PMID:40418421
YAP1 promoter-associated noncoding RNA affects Ewing sarcoma cell tumorigenicity by regulating YAP1 expression., PMID:40414844
Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series., PMID:40414239
Defective autophagy in a fibroin secretion-deficient silkworm mutant., PMID:40413758
Protein Structure-based FUS Mutational Subtypes Are Associated With Protein Mislocalization in Amyotrophic Lateral Sclerosis Patients., PMID:40413303
Long Non-coding RNA NORAD Suppresses Erastin-induced Ferroptosis in Breast Cancer by Upregulating SLC7A11 via Targeting the FUS/NR3C1 Axis-experimental Studies., PMID:40405780
Drug repurposing candidates for amyotrophic lateral sclerosis using common and rare genetic variants., PMID:40395632
Nuclear SREBP2 condensates regulate the transcriptional activation of lipogenic genes and cholesterol homeostasis., PMID:40394324
DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases., PMID:40394046
Huashi Jiedu Decoction Enhances 5-Fluorouracil Efficacy in Gastric Cancer via miRNA-21-3p/p53 Pathway., PMID:40391175
Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS., PMID:40389397
ca-circSCN8A Promotes HPASMCs Ferroptosis via LLPS Initiated R-Loop., PMID:40384439
KHSRP promotes the malignant behavior and cisplatin resistance of bladder cancer cells through the CLASP2/MAPRE1 axis., PMID:40382315
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates., PMID:40381401
Small-molecule dissolution of stress granules by redox modulation benefits ALS models., PMID:40369342
Targets and Gene Therapy of ALS (Part 1)., PMID:40362304
Spatiotemporal deciphering of dynamic the FUS interactome during liquid-liquid phase separation in living cells., PMID:40346035
Expression and Effects of FUS/Sfrp5/Wnt5 in Atherosclerosis Development., PMID:40340876
Investigating the role of conformational heterogeneity in FUS-RRM fibrillation., PMID:40334877
Synaptic defects in adult drosophila motor neurons in a model of amyotrophic lateral sclerosis., PMID:40327885
Respiratory function, survival, and NIV prevalence over time in ALS - a PRECISION ALS study., PMID:40326916
Clinical trajectories of genetic variants in ALS: a European observational study within PRECISION-ALS., PMID:40326912
Nanoscale domains govern local diffusion and aging within FUS condensates., PMID:40321778
Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers., PMID:40291716
Nanoscale domains govern local diffusion and aging within FUS condensates., PMID:40291709
TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis., PMID:40287755
Purification of Low-Complexity Domain Proteins FUS, EWSR1, and Their Fusions., PMID:40285687
Pathophysiology, Clinical Heterogeneity, and Therapeutic Advances in Amyotrophic Lateral Sclerosis: A Comprehensive Review of Molecular Mechanisms, Diagnostic Challenges, and Multidisciplinary Management Strategies., PMID:40283201
Molecular insights into the effect of 1,6-hexanediol on FUS phase separation., PMID:40281357
A non-tethering role for the Drosophila Pol θ linker domain in promoting damage resolution., PMID:40275613
Aberrant phase separation drives membranous organelle remodeling and tumorigenesis., PMID:40273917
Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling., PMID:40266667
Investigating the neuroprotective effects of strawberry extract against diesel soot-induced motor dysfunction in Drosophila: an in-vivo and in-silico study., PMID:40255255
Deciphering the Contribution of Circular RNAs to Age-Related Decline in Sertoli Cell Survivor., PMID:40248988
Effect of electroacupuncture at Zusanli reduced Olanzapine-induced lipid disturbances in mice via potential liver-brain interaction., PMID:40235271
DNMT1 is required for efficient DSB repair and maintenance of replication fork stability, and its loss reverses resistance to PARP inhibitors in cancer cells., PMID:40234721
The role of JPX in regulating FUS/SLC7A11 signaling pathway mediated ferroptosis in keloid fibroblasts and its potential in scar repair., PMID:40233433
Utility of Protein Kinase C Beta II Immunohistochemistry in Differential Diagnosis of Ewing Sarcoma., PMID:40230184
Selective cellular and regional vulnerability in frontotemporal lobar degeneration: a scoping review., PMID:40207209
Correcting tau isoform ratios with a long-acting antisense oligonucleotide alleviates 4R-tauopathy phenotypes., PMID:40206658
Ultrasound-responsive nanoparticles for imaging and therapy of brain tumors., PMID:40206140
For research use only. Not for human or drug use.
