Catalog No.
YHE12901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro4-Arg267
Predicted molecular weight
31.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35568
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IRS-1, IRS1, Insulin receptor substrate 1
TXNIP participates in the pathogenesis of PCOS by regulating glycolysis in granulosa cells., PMID:40499496
A potential herbal component for the future treatment of fatty liver disease: Geniposide from gardenia., PMID:40487402
IL-37 inhibited inflammation to improve gestational diabetes mellitus through the GSK3/NF-κB pathway., PMID:40474280
IGF-1 contributes to cardiovascular protection in obesity by upregulating Na+/K+-ATPase activity and modulating key signaling pathways in rats on a high-fat diet., PMID:40441487
Estradiol and vitamin D exert a synergistic effect on preventing osteoporosis via the miR-351-5p/IRS1 axis and mTOR/NFκB signaling pathway., PMID:40436926
Dietary Insulinogenic Amino Acid Restriction Improves Glucose Metabolism in a Neonatal Piglet Model., PMID:40431415
Antidiabetic GLP-1 Receptor Agonists Have Neuroprotective Properties in Experimental Animal Models of Alzheimer's Disease., PMID:40430434
Protective Effects of Lotus Seedpod Extract on Hepatic Lipid and Glucose Metabolism via AMPK-Associated Mechanisms in a Mouse Model of Metabolic Syndrome and Oleic Acid-Induced HepG2 Cells., PMID:40427477
Single cell RNA sequencing reveals the role of local renin-angiotensin system in regulating ovarian physiological cycle and promoting PCOS., PMID:40425574
Glucose consumption and uptake in HepG2 cells is improved by aqueous extracts from leaves, but not rhizomes, of Posidonia oceanica (L.) Delile via GLUT-4 upregulation., PMID:40413340
Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight into vascular dysfunction and hepatic steatosis., PMID:40406487
Sex- and depot-specific differences in cellular insulin responsiveness during adipose expansion., PMID:40404120
Camel milk endogenous peptides ameliorated hyperglycemia in high-fat diet-fed C57BL/6 J mice in association with modulation of gut microbiota and the IRS/Akt and JNK/p38 pathways., PMID:40382047
Syringic Acid in Canarium odontophyllum for Diabetes and Obesity - A Review., PMID:40377865
Insulin level regulators may affect cognitive ability caused by motion sickness: an experimental study., PMID:40377761
Valorization of Winemaking By-Products: White and Red Grape Seed Oils Improve Glucose Consumption and Uptake In Vitro., PMID:40363740
The Effect and Mechanism of Regular Exercise on Improving Insulin Impedance: Based on the Perspective of Cellular and Molecular Levels., PMID:40362436
Palmitic acid and lipopolysaccharide induce macrophage TNFα secretion, suppressing browning regulators and mitochondrial respiration in adipocytes., PMID:40348028
SIRT1-Mediated Regulation of STAT3/SOCS3 Inhibits Insulin Resistance in Trophoblast Cells and Improves Gestational Diabetes Mellitus., PMID:40346854
Spatiotemporal Expression of IRS-1 During Brain Development and its Role in Neural Stem Cell Differentiation., PMID:40314831
Elevated cortisol concentration in preterm sheep fetuses impacts heart development., PMID:40296367
p-Synephrine ameliorates non-alcoholic fatty liver disease by regulating liver-adipose axis via AMPK/NF-kappa B pathway., PMID:40294666
Metabolic Signalling Peptides and Their Relation to Clinical and Demographic Characteristics in Acute and Recovered Females with Anorexia Nervosa., PMID:40284205
Defective Intracellular Insulin/IGF-1 Signaling Elucidates the Link Between Metabolic Defect and Autoimmunity in Vitiligo., PMID:40277891
Non-enzymatic modification of aminophospholipids induces angiogenesis, inflammation, and insulin signaling dysregulation in human renal glomerular endothelial cells in vitro., PMID:40268103
Longitudinal Analysis of Placental IRS1 DNA Methylation and Childhood Obesity., PMID:40243885
Kumquat Fruit Administration Counteracts Dysmetabolism-Related Neurodegeneration and the Associated Brain Insulin Resistance in the High-Fat Diet-Fed Mice., PMID:40243721
Metabolic Regulation Mechanisms of the Hypoglycemic and Anti-Obesity Effects of Ficus pumila L. Var. awkeotsang Achene Extracts in 3T3-L1 Cells., PMID:40241690
Preventive effects of turmeric against HFD/STZ-induced type 2 diabetes in mice by activating IRS1/PI3K/Akt signaling in association with gut microbiota metabolism., PMID:40232278
N-acetylcysteine influence on PI3K/Akt/mTOR and sphingolipid pathways in rats with MASLD induced by HFD: a promising new therapeutic purpose., PMID:40220949
Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension., PMID:40196172
Clostridium butyricum ameliorates post-gastrectomy insulin resistance by regulating the mTORC1 signaling pathway through the gut-liver axis., PMID:40188705
Stress-induced hyperglycemia and expression of glucose cell transport genes in skeletal muscle of critically ill patients: a cross-sectional study., PMID:40179269
Hypoglycemic Effects and Mechanisms of Polyphenols From Myrica rubra Pomace in Type 2 Diabetes (db/db) Mice., PMID:40171790
Steam explosion improved the physicochemical properties, hypoglycemic effects of polysaccharides from Clerodendranthus spicatus leaf via regulating IRS1/PI3K/AKT/GSK-3β signaling pathway in IR-HepG2 cells., PMID:40154696
Tangeretin Unravels Metabolic Dysfunction-Associated Fatty Liver Disease in Rats by Enhancing the IRS/Akt Pathway., PMID:40141836
Electroacupuncture alleviates insulin resistance and impacts the hypothalamic IRS-1/PI3K/AKT pathway and miRNA-29a-3p in a rat model of type 2 diabetes., PMID:40116412
Methylglyoxal-induced neuronal dysfunction: Linking diabetes to Alzheimer's disease through cytoskeletal disruption., PMID:40107340
Improvement of Glucose Metabolism by Pennogenin 3-O-β-Chacotrioside via Activation of IRS/PI3K/Akt Signaling and Mitochondrial Respiration in Insulin-Resistant Hepatocytes., PMID:40103416
Total dietary fiber of tartary buckwheat alleviates T2DM through the IRS-1/PI3K/AKT pathway and gut microbiota-bile acids-TGR5/FXR axis in db/db mice., PMID:40101829
Polysaccharide from Momordica charantia L. Alleviates Type 2 Diabetes Mellitus in Mice by Activating the IRS1/PI3K/Akt and AMPK Signaling Pathways and Regulating the Gut Microbiota., PMID:40085053
snRNA-Seq and Spatial Transcriptome Reveal Cell-Cell Crosstalk Mediated Metabolic Regulation in Porcine Skeletal Muscle., PMID:40079370
Unveiling Gestational Diabetes: An Overview of Pathophysiology and Management., PMID:40076938
Timosaponin AⅢ inhibits ectopic lipid deposition and enhances the browning of white adipose tissue., PMID:40074140
PRDM16 deficiency promotes podocyte injury by impairing insulin receptor signaling., PMID:40065145
Metformin ablates high fat diet-induced skeletal muscle hypertrophy and elevation of sarcolemmal GLUT4 when feeding is initiated in young adult male mice., PMID:40052722
DUSP9-mediated inhibition of IRS1/PI3K/AKT pathway contributes to insulin resistance and metabolic dysfunction in gestational diabetes mellitus., PMID:40020430
Effects of high-pressure homogenization on phenolics profile, antioxidant activity, α-glucosidase inhibitory activity, and insulin resistance of peach juice during simulated gastrointestinal digestion., PMID:40007514
Potential Biomarkers and Therapeutic Targets in Hepatitis B Virus-related Acute Liver Failure: Interplay of the Ferroptosis, Autophagy and Immune Responses., PMID:39991755
Alginate nanoparticles loaded with enriched polyphenols of Desmodium gangeticum alleviates diabetes induced oxidative and inflammatory stress in Rin-5F cells via GLUT2/IRS-1/NF-κB pathway., PMID:39984097
For research use only. Not for human or drug use.
