Catalog No.
YHE10501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu263-Gly523
Predicted molecular weight
42.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35398
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NR1F1, Nuclear receptor ROR-alpha, RZRA, Nuclear receptor subfamily 1 group F member 1, RAR-related orphan receptor A, Retinoid-related orphan receptor-alpha, RORA, Nuclear receptor RZR-alpha
Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseases., PMID:40441863
Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis., PMID:40434419
Lnc MSTRG 4701.7 targets miR-1786/RORa to competitively regulate proliferation and apoptosis in chicken follicular granulosa cells., PMID:40370832
Ji-Ming-San enhances intestinal circadian rhythms and mitigates colitis in mice: The role of epithelial RORα., PMID:40252431
Maresin-1 alleviates lipid peroxidation-induced ferroptosis after radiation-induced brain injury in mice through the RORα/NRF2 pathway., PMID:40239796
MEX3A promotes cell proliferation by regulating the RORA/β-catenin pathway in hepatocellular carcinoma., PMID:40235874
Environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin induces non-obstructive azoospermia: New insights from network toxicology, integrated machine learning, and biomolecular modeling., PMID:40215689
RORα fine-tunes the circadian control of hepatic triglyceride synthesis and gluconeogenesis., PMID:40140523
RORα inhibits proliferation and chemoresistance through AKR1A1-induced glucose and lipid reprogramming in gastric cancer., PMID:40096932
The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow., PMID:40079843
The Retinoic-Acid-Related Orphan Receptor Alpha May Be Highly Involved in the Regulation of Seasonal Hair Molting., PMID:40004044
RORA Regulates Autophagy in Hair Follicle Stem Cells by Upregulating the Expression Level of the Sqstm1 Gene., PMID:40001602
Melatonin-Mediated Circadian Rhythm Signaling Exhibits Bidirectional Regulatory Effects on the State of Hair Follicle Stem Cells., PMID:40001528
Interaction between clock genes, melatonin and cardiovascular outcomes from ICU patients., PMID:39961935
Modulatory effects of cinnamomi cortex and its components epicatechin and linalool on skin circadian rhythms., PMID:39915616
Identifying CSNK1E as a therapeutic target in thyroid cancer among the core circadian clock genes., PMID:39904793
Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins., PMID:39901247
DNMT1-driven methylation of RORA facilitates esophageal squamous cell carcinoma progression under hypoxia through SLC2A3., PMID:39741267
Specialized pro-resolving mediator Maresin 1 attenuates pain in a mouse model of osteoarthritis., PMID:39617202
Molecular Signatures of Resilience to Alzheimer's Disease in Neocortical Layer 4 Neurons., PMID:39574639
Exploring the material basis and molecular targets of Changma Xifeng tablet in treating Tourette syndrome: an integrative approach of network pharmacology and miRNA analysis., PMID:39436634
Epidermal RORα Maintains Barrier Integrity and Prevents Allergic Inflammation by Regulating Late Differentiation and Lipid Metabolism., PMID:39409027
Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency., PMID:39390588
The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cells., PMID:39341888
UBE2T promotes stage I lung adenocarcinoma progression through PBX1 ubiquitination and PBX1/RORA regulation., PMID:39289660
Exosomal miR-205-5p contributes to the immune liver injury induced by trichloroethylene: Pivotal role of RORα mediating M1 Kupffer cell polarization., PMID:39278002
Aging abolishes circadian rhythms and disrupts temporal organization of antioxidant-prooxidant status, endogenous clock activity and neurotrophin gene expression in the rat temporal cortex., PMID:39244007
IGF2BP3 regulates macrophage-induced inflammation and liver damage in acute-on-chronic liver failure via the RORα-NF-κB signaling axis., PMID:39232362
Genetic structure analysis of yak breeds and their response to adaptive evolution., PMID:39218165
Retinal Pigment Epithelium and Outer Retinal Atrophy (RORA) in Retinitis Pigmentosa: Functional, Structural, and Genetic Evaluation., PMID:39212608
Melatonin Receptor Expression in Primary Uveal Melanoma., PMID:39201396
A majority of circadian clock genes are expressed in estrogen receptor and progesterone receptor status-dependent manner in breast cancer., PMID:39193850
RORα negatively regulates BCG-induced trained immunity., PMID:39159505
Induction of hepatic fibrosis in mice with schistosomiasis by extracellular microRNA-30 derived from Schistosoma japonicum eggs., PMID:39139565
MiR-143-5p regulates the proangiogenic potential of human dental pulp stem cells by targeting HIF-1α/RORA under hypoxia: A laboratory investigation in pulp regeneration., PMID:39126298
Nobiletin promotes lipolysis of white adipose tissue in a circadian clock-dependent manner., PMID:39094217
GATA2‑miR‑374a axis promotes vascular smooth muscle cells proliferation, migration via targeting circTADA2A/RORA axis., PMID:39071901
Retinoic acid receptor-related orphan receptor alpha and synthetic RORα agonist against invasion and metastasis in tongue squamous cell carcinoma., PMID:39047426
Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p regulates prostate cancer cell proliferation and inflammation through the RORA gene., PMID:39010137
Mining key circadian biomarkers for major depressive disorder by integrating bioinformatics and machine learning., PMID:38874508
More than the clock: distinct regulation of muscle function and metabolism by PER2 and RORα., PMID:38850551
Nobiletin Stimulates Adrenal Hormones and Modulates the Circadian Clock in Mice., PMID:38794729
The Potential Roles of Host Cell miRNAs in Fine-Tuning Bovine Coronavirus (BCoV) Molecular Pathogenesis, Tissue Tropism, and Immune Regulation., PMID:38792727
A proximal enhancer regulates RORA expression during early human Th17 cell differentiation., PMID:38788884
RAR-related orphan receptor alpha and the staggerer mice: a fine molecular story., PMID:38766309
Retinoic acid related orphan receptor α is a genetic modifier that rescues retinal degeneration in a mouse model of Stargardt disease and Dry AMD., PMID:38755404
The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression., PMID:38718296
Single-nucleus transcriptomics and chromatin accessibility analysis of musk gland development in Chinese forest musk deer (Moschus berezovskii)., PMID:38644525
A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation., PMID:38582945
Association Between RORA Polymorphisms and Obesity., PMID:38570441
For research use only. Not for human or drug use.
