Catalog No.
YHE08401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp30-Leu239
Predicted molecular weight
27.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35240
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Merlin, Neurofibromin-2, Schwannomerlin, NF2, SCH, Moesin-ezrin-radixin-like protein, Schwannomin
Atypical Hippo signaling network: uncovering novel insights into head and neck cancer biology and advancements in precision intervention., PMID:40486910
Transcriptional landscape of pleural mesothelioma patients in relation to NF2 gene mutational status., PMID:40484892
Clinical benefits of immune checkpoint inhibitors for malignant peripheral nerve sheath tumors with NF2 mutation: a case report., PMID:40469286
Merlin immunoreactivity fails to predict neurofibromatosis type 2 mutations in human meningiomas., PMID:40447281
BaZiBuShen inhibition of oocyte ferroptosis in primordial follicles through activation of NF2-YAP pathway for the treatment of chemotherapy-induced premature ovarian insufficiency., PMID:40412775
Morphological control of merlin-Rac antagonism in proliferation-promoting signaling., PMID:40392939
Molecular Mechanisms of Tumor Progression and Novel Therapeutic and Diagnostic Strategies in Mesothelioma., PMID:40362535
Radiation-Induced Meningiomas Have an Aggressive Clinical Course: Genetic Signature Is Limited to NF2 Alterations, and Epigenetic Signature Is H3K27me3 Loss., PMID:40359980
Ocular manifestations in pediatric tumor suppressor gene mutations: a case series and literature review of RB1, NF1, NF2, VHL, and TSC., PMID:40346602
Multiplatform molecular analyses reveal two molecular subgroups of NF2-related schwannomatosis vestibular schwannomas with distinct tumour microenvironment and therapeutic vulnerabilities., PMID:40343504
Conditioned medium from painful non-NF2 schwannomatosis tumors increases pain behaviors in mice., PMID:40328914
Harnessing the FGFR2/NF2/YAP signaling-dependent necroptosis to develop an FGFR2/IL-8 dual blockade therapeutic strategy., PMID:40319089
[Clinicopathological features of primary thoracic synovial sarcoma: a study of 42 cases]., PMID:40302578
Pathogenic Variants and Allele Loss of the NF2 and LZTR1 Gene in Sporadic Vestibular Schwannoma., PMID:40295009
Similar Allele Frequencies of Two Pathogenic NF2 variants in Each of Nine Sporadic Vestibular Schwannomas., PMID:40280714
Genetics and current research models of Mendelian tumor predisposition syndromes with ocular involvement., PMID:40274012
In-frame insertions of SOX10 are highly enriched and characterize a distinct transcriptomic profile in gastrointestinal schwannomas., PMID:40272443
High de novo mutation rate in Iranian NF2-related schwannomatosis patients with a report of a novel NF2 mutation., PMID:40249415
Interactions among Merlin, Arkadia, and SKOR2 mediate NF2-associated human Schwann cell proliferation., PMID:40188079
Structure-based optimization of TEAD inhibitors: Exploring a novel subpocket near Glu347 for the treatment of NF2-mutant cancer., PMID:40168885
Utility and limitations of Merlin immunohistochemistry for mesothelioma diagnosis in tissue sections and cell blocks., PMID:40153913
Estrogen receptor α suppresses hepatocellular carcinoma by restricting M2 macrophage infiltration through the YAP-CCL2 axis., PMID:40148834
Spatial mapping of immune cell environments in NF2-related schwannomatosis vestibular schwannoma., PMID:40140675
Strong nuclear expression of HOXB13 is a reliable surrogate marker for DNA methylome profiling to distinguish myxopapillary ependymoma from spinal ependymoma., PMID:40137996
Alterations in the Hippo Signaling Pathway During Adenogenesis Impairment in Postnatal Mouse Uterus., PMID:40106220
Nf2-FAK signaling axis is critical for cranial bone ossification and regeneration., PMID:40075076
Unusual fundus lesion in mosaic neurofibromatosis type 2., PMID:40069121
Effect of Simvastatin on Irradiated Primary Vestibular Schwannoma Cells., PMID:40059781
Gene therapy and genome-editing for schwannoma in NF2-related schwannomatosis: current understanding and future directions., PMID:40055258
NF2-related schwannomatosis: A view from within the inner ear., PMID:40049083
Acylcarnitine Profiling in Meningiomas with Different NF2 Mutation Statuses., PMID:40004036
Cas9 Mouse Model of Skull Base Meningioma Driven by Combinational Gene Inactivation in Meningeal Cells., PMID:39996452
Anaplastic meningioma in a 6-year-old with somatic YAP1::MAML2 fusion and multiple endocrine neoplasia type 4 (MEN4) syndrome., PMID:39985924
Fundamentals and Applications of Dual-Frequency Magnetic Particle Spectroscopy: Review for Biomedicine and Materials Characterization., PMID:39985275
A genome-wide CRISPR-Cas9 knockout screen using dynamin knockout cells identifies Nf2 and Traf3 as genes involved in dynamin-independent endocytosis., PMID:39978713
Expression of SSTR2a, FAP, HER2 and HER3 as potential radionuclide therapy targets in higher-grade meningioma., PMID:39969538
Update on Cancer and Central Nervous System Tumor Surveillance in Pediatric NF2-, SMARCB1-, and LZTR1-Related Schwannomatosis., PMID:39937237
NF2 is Essential for Human Endoderm Development., PMID:39921490
Current molecular understanding of central nervous system schwannomas., PMID:39910685
Lead exposure promotes NF2-wildtype meningioma cell proliferation through the Merlin-Hippo signaling pathway., PMID:39894505
NF2 loss-of-function and hypoxia drive radiation resistance in grade 2 meningiomas., PMID:39886924
Rhabdomyosarcoma With EWSR1::NF2 Gene Fusion: A Case Report Potentially Expanding Its Genetic Spectrum., PMID:39873201
Crb3 and NF2: A dynamic duo that controls assembly of the apical junctions and barrier function via Rho/ROCK signaling., PMID:39868176
Clinical and molecular characteristics and long-term outcomes of pediatric intracranial meningiomas: a comprehensive analysis from a single neurosurgical center., PMID:39856730
Alternative driver pathways in peripheral nerve sheath tumors - including DICER1 and/or KRAS alterations., PMID:39846292
WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function., PMID:39841844
Correlation of Histologic Features with Gene Alterations in Pleural Mesothelioma., PMID:39788204
[Aggressive mucinous tubular and spindle cell carcinoma of the kidney: a clinicopathological and genetic analysis of four cases]., PMID:39762168
NF2 can mediate the expression of CAMK2A in a tissue specific manner., PMID:39738767
For research use only. Not for human or drug use.
