Catalog No.
YHE07801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu152-Ile289
Predicted molecular weight
18.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35226
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RING finger protein 51, BMI1, RNF51, Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, PCGF4
The BMI1-Angiopoietin-2 axis as an independent prognostic factor in colorectal cancer., PMID:40449824
Thymic Bmi-1 hampers γδT17 generation and its derived RORγt-IL-17A signaling to delay cardiac aging., PMID:40366697
Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma., PMID:40239645
In vitro properties of four benign meningioma cells derived from WHO grade 1 meningiomas., PMID:40214859
The transcription repressor Bach2 is required for maintaining the B-1 cell population by regulating self-renewal., PMID:40170867
Effect of pyrroloquinoline quinone on skin aging in Bmi-1 KO mice and underlying mechanisms., PMID:40153371
CircCENPM serves as a CeRNA to aggravate nasopharyngeal carcinoma metastasis and stemness via enhancing BMI1., PMID:40087716
Exogenous BMI1 expression aggravates oral squamous cell carcinomas in tongue epithelia., PMID:40009939
A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation., PMID:39880315
Insights on Bmi-1 therapeutic targeting in head and neck cancers., PMID:39866230
Are rs1042059 and rs11591377 polymorphisms of BMI1 gene related to leukemia?, PMID:39826011
Insights Into the Role of Bmi-1 Deregulation in Promoting Stemness and Therapy Resistance in Glioblastoma: A Narrative Review., PMID:39791545
Berberine Derivative B68 Promotes Tumor Immune Clearance by Dual-Targeting BMI1 for Senescence Induction and CSN5 for PD-L1 Degradation., PMID:39721027
B-cell-Specific Moloney Murine Leukemia Virus Integration Site 1 and Fas Ligand Expression in Colorectal Cancer Progression and Prognosis., PMID:39662015
METTL3-Mediated m6A Modification Regulates the Polycomb Repressive Complex 1 Components BMI1 and RNF2 in Hepatocellular Carcinoma Cells., PMID:39625677
Activation of Wnt/β-catenin signaling to increase B lymphoma Moloney murine leukemia virus insertion region 1 by lithium chloride attenuates the toxicity of cisplatin in the HEI-OC1 auditory cells., PMID:39608515
KGF secreted from HSCs activates PAK4/BMI1, promotes HCC stemness through PI3K/AKT pathway., PMID:39544166
Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1., PMID:39537923
BMI-1 in Breast Cancer - Biological Role and Clinical Implications., PMID:39429016
The Endogenous Expression of BMI1 in Adult Human Eyes., PMID:39404434
SOX4-BMI1 axis promotes non-small cell lung cancer progression and facilitates angiogenesis by suppressing ZNF24., PMID:39349443
Gambogic acid impairs the maintenance and therapeutic resistance of glioma stem cells by targeting B-cell-specific Moloney leukemia virus insert site 1., PMID:39326139
Role of HIF-1α-Activated IL-22/IL-22R1/Bmi1 Signaling Modulates the Self-Renewal of Cardiac Stem Cells in Acute Myocardial Ischemia., PMID:39264501
A new digital droplet PCR method for looking at epigenetics in diffuse large B-cell lymphomas: The role of BMI1, EZH2, and USP22 genes., PMID:39255961
Bmi-1 Epigenetically Orchestrates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells to Delay Bone Aging., PMID:39225325
Exposure to endocrine disruptor DEHP promotes the progression and radiotherapy resistance of pancreatic cancer cells by increasing BMI1 expression and properties of cancer stem cells., PMID:39216224
Development of a Bmi1+ Cardiac Mouse Progenitor Immortalized Model to Unravel the Relationship with Its Protective Vascular Endothelial Niche., PMID:39201501
Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting Metastasis in Colorectal Cancer., PMID:39191496
BMI1 Inhibition Improves Lesion Burden in Cerebral Cavernous Malformations., PMID:39186529
Investigating the Association between LncRNA NR2F2-AS1, miR-320b, and BMI1 in Gastric Cancer: Insights into Expression Profiles as Potential Biomarkers for Disease Management., PMID:38952161
Bmi-1 promotes the proliferation, migration and invasion, and inhibits cell apoptosis of human retinoblastoma cells via RKIP., PMID:38914697
Crosstalk between circBMI1 and miR-338-5p/ID4 inhibits acute myeloid leukemia progression., PMID:38864460
CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway., PMID:38744845
Bmi1 facilitates the progression of cholangiocarcinoma by inhibiting Foxn2 expression dependent on a histone H2A ubiquitination manner., PMID:38705565
Modulating PCGF4/BMI1 Stability Is an Efficient Metastasis-Regulatory Strategy Used by Distinct Subtypes of Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma., PMID:38670529
Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFβ1-Induced Epithelial-Mesenchymal Transition., PMID:38617548
The transcription factor BMI1 increases hypoxic signaling in oral cavity epithelia., PMID:38599260
Graphene Quantum Dots Eradicate Resistant and Metastatic Cancer Cells by Enhanced Interfacial Inhibition., PMID:38597827
lncRNA CCAT2 Protects Against Cardiomyocyte Injury After Myocardial Ischemia/Reperfusion by Regulating BMI1 Expression., PMID:38556336
Polycomb repressive complex 1 modulates granulosa cell proliferation in early folliculogenesis to support female reproduction., PMID:38389850
Cancer-associated fibroblast-derived extracellular vesicles promote lymph node metastases in oral cavity squamous cell carcinoma by encapsulating ITGB1 and BMI1., PMID:38254031
Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells., PMID:38147957
PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells., PMID:38141761
BMI1 Silencing Liposomes Suppress Postradiotherapy Cancer Stemness against Radioresistant Hepatocellular Carcinoma., PMID:37988576
Cathepsin-facilitated invasion of BMI1-high hepatocellular carcinoma cells drives bile duct tumor thrombi formation., PMID:37923799
BMI1 Transduction of Human Airway Epithelial Cells for Expansion of Proliferation and Differentiation., PMID:37856028
BMI1-induced CD127+KLRG1+ memory T cells enhance the efficacy of liver cancer immunotherapy., PMID:37562671
Sonic Hedgehog and WNT Signaling Regulate a Positive Feedback Loop Between Intestinal Epithelial and Stromal Cells to Promote Epithelial Regeneration., PMID:37481204
BMI-1 activates hepatic stellate cells to promote the epithelial-mesenchymal transition of colorectal cancer cells., PMID:37398890
[Helicobacter pylori promotes gastric cancer metastasis via up-regulating the expression of Bmi-1]., PMID:37340921
For research use only. Not for human or drug use.
