Catalog No.
YHE06801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu208-Ser530
Predicted molecular weight
37.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35052
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Glypican-1, GPC1
Structural Features of Glypicans and their Impact on Wnt Signaling in Cancer., PMID:40416340
Gut Microbiota-Based Immunotherapy: Engineered Escherichia coli Nissle 1917 for Oral Delivery of Glypican-1 in Pancreatic Cancer., PMID:40282924
Changes in the Proteomic Profile After Audiogenic Kindling in the Inferior Colliculus of the GASH/Sal Model of Epilepsy., PMID:40076950
miR-143-3p/TET1 Axis Regulates GPC1 Through DNA Methylation and Impairs the Malignant Biological Behaviour of HCC via the Hippo Signalling Pathway., PMID:39823268
Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer., PMID:39793167
Distinct molecular properties and functions of small EV subpopulations isolated from human umbilical cord MSCs using tangential flow filtration combined with size exclusion chromatography., PMID:39783889
Neuroinflammation and glycosylation-related cerebrospinal fluid proteins for predicting functional decline in amyotrophic lateral sclerosis: a proteomic study., PMID:39624674
The anti-glypican 1 AT101 antibody as targeting agent to effectively deliver chitosan nanobubbles to glioblastoma cells., PMID:39620421
In-depth analysis of lymph node metastasis-related sialylated protein profiling and their clinical and biological significance in colorectal cancer using mass spectrometry and multi-omics technologies., PMID:39558044
A Mem-dELISA platform for dual color and ultrasensitive digital detection of colocalized proteins on extracellular vesicles., PMID:39413723
Extracellular glypican-1 affects tumor progression and prognosis in esophageal cancer., PMID:39300946
IRTIDP: A simple integrated real-time isolation and detection platform for small extracellular vesicles Glypican-1 in pancreatic cancer patients., PMID:39191106
Interplay between glypican-1, amyloid-β and tau phosphorylation in human neural stem cells., PMID:38992568
Pan-cancer analysis and the oncogenic role of Glypican 1 in hepatocellular carcinoma., PMID:38982153
Evaluation of antitumor potential of an anti-glypican-1 monoclonal antibody in preclinical lung cancer models reveals a distinct mechanism of action., PMID:38966167
Codetection of Proteins and RNAs on Extracellular Vesicles for Pancreatic Cancer Early Diagnosis., PMID:38626343
Diagnostic and prognostic value of circulating exosomal glypican-1 in pancreatic cancer: a meta-analysis., PMID:38470244
Glypican-1-targeted antibody-drug conjugate inhibits the growth of glypican-1-positive glioblastoma., PMID:38417223
HIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process., PMID:38365849
Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space., PMID:38252473
Extracellular Vesicular Analysis of Glypican 1 mRNA and Protein for Pancreatic Cancer Diagnosis and Prognosis., PMID:38204202
Glypican-1 may be a plasma biomarker for predicting the rupture of small intracranial aneurysms., PMID:38154549
The glycerophosphocholine acyltransferase Gpc1 contributes to phosphatidylcholine biosynthesis, long-term viability, and embedded hyphal growth in Candida albicans., PMID:38072057
A de novo variant in RERE causes autistic behavior by disrupting related genes and signaling pathway., PMID:38018232
A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma., PMID:38017492
Primary breast tumor induced extracellular matrix remodeling in premetastatic lungs., PMID:37903851
Immuno-PET and Targeted α-Therapy Using Anti-Glypican-1 Antibody Labeled with 89Zr or 211At: A Theranostic Approach for Pancreatic Ductal Adenocarcinoma., PMID:37827841
Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma., PMID:37775746
Immunohistochemical Evaluation of the Expression of Specific Membrane Antigens in Patients with Pancreatic Ductal Adenocarcinoma., PMID:37760554
Precise Identification and Profiling of Surface Proteins of Ultra Rare Tumor Specific Extracellular Vesicle with Dynamic Quantitative Plasmonic Imaging., PMID:37638659
Effects and Mechanisms of Cage versus Floor Rearing System on Goose Growth Performance and Immune Status., PMID:37627473
Proteomic Investigation of Differential Interactomes of Glypican 1 and a Putative Disease-Modifying Variant of Ataxia., PMID:37585105
Targeting Glypican-1 Reverses Resistance to 5-Fluorouracil in Esophageal Adenocarcinoma Cells., PMID:37500147
Variations in Genes Encoding Human Papillomavirus Binding Receptors and Susceptibility to Cervical Precancer., PMID:37410084
Quantification of GPC1(+) Exosomes Based on MALDI-TOF MS In Situ Signal Amplification for Pancreatic Cancer Discrimination and Evaluation., PMID:37368911
Dual Tumor Exosome Biomarker Co-recognitions Based Nanoliquid Biopsy for the Accurate Early Diagnosis of Pancreatic Cancer., PMID:37288703
The acyltransferase Gpc1 is both a target and an effector of the unfolded protein response in Saccharomyces cerevisiae., PMID:37269946
Nano-particulate Toll-like Receptor 9 Agonist Potentiates the Antitumor Activity of Anti-Glypican-1 Antibody., PMID:37247902
The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer., PMID:37031249
Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior., PMID:36944188
Investigation of Glypican-4 and -6 by Infrared Spectral Imaging during the Hair Growth Cycle., PMID:36901723
Development and validation of an RBP gene signature for prognosis prediction in colorectal cancer based on WGCNA., PMID:36895014
Interplay between APP and glypican-1 processing and α-synuclein aggregation in undifferentiated and differentiated human neural progenitor cells., PMID:36790131
Pharmacokinetics and Biodistribution of 89Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma., PMID:36602058
Glypican 1 promotes proliferation and migration in esophagogastric adenocarcinoma via activating AKT/GSK/β-catenin pathway., PMID:36388647
Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities., PMID:36159010
GPC1 Is Associated with Poor Prognosis and Treg Infiltration in Colon Adenocarcinoma., PMID:36158119
The Proteoglycan Glypican-1 as a Possible Candidate for Innovative Targeted Therapeutic Strategies for Pancreatic Ductal Adenocarcinoma., PMID:36142190
Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling., PMID:36057966
Modulation of cardiac voltage-activated K+ currents by glypican 1 heparan sulfate proteoglycan., PMID:36049528
For research use only. Not for human or drug use.
