Catalog No.
YHE00701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr35-Asn276
Predicted molecular weight
29.79 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P32456
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Guanine nucleotide-binding protein 2, HuGBP-2, GBP-2, GTP-binding protein 2, GBP2, Interferon-induced guanylate-binding protein 2, Guanylate-binding protein 2
Extracellular vesicle-packaged GBP2 from macrophages aggravates sepsis-induced acute lung injury by promoting ferroptosis in pulmonary vascular endothelial cells., PMID:40156957
Novel insights into the molecular mechanisms of sepsis-associated acute kidney injury: an integrative study of GBP2, PSMB8, PSMB9 genes and immune microenvironment characteristics., PMID:40155864
Exosomes derived let-7f-5p is a potential biomarker of SLE with anti-inflammatory function., PMID:40144341
Helicobacter pylori CagA and Cag type IV secretion system activity have key roles in triggering gastric transcriptional and proteomic alterations., PMID:40047510
Crystal structures reveal nucleotide-induced conformational changes in G motifs and distal regions in human guanylate-binding protein 2., PMID:39987405
Ferroptosis-related genes participate in the microglia-induced neuroinflammation of spinal cord injury via NF-κB signaling: evidence from integrated single-cell and spatial transcriptomic analysis., PMID:39799354
Unveiling Key Biomarkers and Mechanisms in Septic Cardiomyopathy: A Comprehensive Transcriptome Analysis., PMID:39735900
Extracellular vesicles of ADSCs inhibit ischemic stroke-induced pyroptosis through Gbp3 regulation: A role for the NLRP3/GSDMD signaling pathway., PMID:39721455
Gbp2 driving macrophages dynamics in murine heart transplant., PMID:39709712
Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson's model., PMID:39681872
Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis., PMID:39666559
A multidimensional recommendation framework for identifying biological targets to aid the diagnosis and treatment of liver metastasis in patients with colorectal cancer., PMID:39449040
Erlotinib regulates short-term memory, tau/Aβ pathology, and astrogliosis in mouse models of AD., PMID:39434878
Defenders of the Transcriptome: Guard Protein-Mediated mRNA Quality Control in Saccharomyces cerevisiae., PMID:39408571
GBP2 Regulates Lipid Metabolism by Inhibiting the HIF-1 Pathway to Alleviate the Progression of Allergic Rhinitis., PMID:39397223
The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site., PMID:39337476
CD4+ Effective Memory T Cell Markers GBP2 and LAG3 Are Risk Factors for PTB and COVID-19 Infection: A Study Integrating Single-Cell Expression Quantitative Trait Locus and Mendelian Randomization Analyses., PMID:39337460
Identification and analysis correlation between hub genes and immune cell infiltration related to LPS-induced cognitive impairment., PMID:39286150
Weighted gene co-expression network analysis identified GBP2 connected to PPARα activity and liver cancer., PMID:39251636
Crosstalk between GBP2 and M2 macrophage promotes the ccRCC progression., PMID:39222374
Genistein-3'-sodium sulfonate promotes brain functional rehabilitation in ischemic stroke rats by regulating astrocytes polarization through NF-κB signaling pathway., PMID:39059603
CENPA facilitates glioma stem cell stemness and suppress ferroptosis to accelerate glioblastoma multiforme progression by promoting GBP2 transcription., PMID:38964117
Type-I interferon shapes peritoneal immunity in cirrhosis and drives caspase-5-mediated progranulin release upon infection., PMID:38936554
Identification of Immune-Related Gene Signature in Schizophrenia., PMID:38863043
Biomarkers Screening and Mechanisms Analysis of the Restraint Stress-Induced Myocardial Injury in Hyperlipidemia ApoE-/- Mice., PMID:38847033
Dan-Lou tablets reduce inflammatory response by inhibiting the activation of NLRP3 inflammasome for coronary heart disease., PMID:38833946
Transcriptomics-based exploration of shared M1-type macrophage-related biomarker in acute kidney injury after kidney transplantation and acute rejection after kidney transplantation., PMID:38815767
Exploring the Role of Guanylate-Binding Protein-2 in Activated Microglia-Mediated Neuroinflammation and Neuronal Damage., PMID:38791092
Transcriptomic Analysis of PDCoV-Infected HIEC-6 Cells and Enrichment Pathways PI3K-Akt and P38 MAPK., PMID:38675921
GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis., PMID:38636926
iNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse., PMID:38538595
Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway., PMID:38461631
Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection., PMID:38404575
Evolution of guanylate binding protein genes shows a remarkable variability within bats (Chiroptera)., PMID:38357541
Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functions., PMID:38348040
GBP2 enhances paclitaxel sensitivity in triple‑negative breast cancer by promoting autophagy in combination with ATG2 and inhibiting the PI3K/AKT/mTOR pathway., PMID:38334171
Ceftriaxone averts neuroinflammation and relieves depressive-like behaviors via GLT-1/TrkB signaling., PMID:38310688
Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10., PMID:38295885
Reanalysis and validation of the transcriptional pleural fluid signature in pleural tuberculosis., PMID:38288122
Transcriptome Analysis of LLC-PK Cells Single or Coinfected with Porcine Epidemic Diarrhea Virus and Porcine Deltacoronavirus., PMID:38257774
Tryptophanyl-Transfer RNA Synthetase Is Involved in a Negative Feedback Loop Mitigating Interferon-γ-Induced Gene Expression., PMID:38247871
Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions., PMID:38228253
A five-protein prognostic signature with GBP2 functioning in immune cell infiltration of clear cell renal cell carcinoma., PMID:38213893
Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction., PMID:38169731
Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury., PMID:38111039
A GH81-type β-glucan-binding protein enhances colonization by mutualistic fungi in barley., PMID:37977140
The Viral Protein Poly(A) Polymerase Catalytic Subunit Interacts with Guanylate-Binding Proteins 2 to Antagonize the Antiviral Ability of Targeting Ectromelia Virus., PMID:37958732
Integrative modeling of guanylate binding protein dimers., PMID:37916607
Construction of a novel prognostic model in skin cutaneous melanoma based on chemokines-related gene signature., PMID:37875556
Identification of mitochondria-related action targets of quercetin in melanoma cells., PMID:37869567
For research use only. Not for human or drug use.
