Catalog No.
YHD99801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg188-Phe449
Predicted molecular weight
32.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P32298
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
G protein-coupled receptor kinase 4, GPRK4, GPRK2L, ITI1, G protein-coupled receptor kinase GRK4, GRK4
Inhibition of GRK4 reduces arrhythmia susceptibility and alleviates connexin43 dysregulation after myocardial infarction., PMID:40484036
Structural insights into the catalytic cycle of G protein-coupled receptor kinase 5 and a possible regulatory site for potassium ion., PMID:40449596
The Beta-Blocker Pharmacogenetic Puzzle: More Pieces of Evidence for Pharmacodynamic Candidate Variants., PMID:40285373
The Role of G-Protein-Coupled Receptor Kinase 4 in Modulating Mitophagy and Oxidative Stress in Cerebral Ischemia-Reperfusion Injury., PMID:40055267
Role of the Palmitoyl Group and of the Amphipathic α Helix in the Membrane Binding of the C-Terminus of G-Protein Receptor Kinase 4α/β., PMID:39977231
Renal glomerular and tubular injury in the offspring of the preeclampsia-like syndrome., PMID:39762506
Genetic variants of accessory proteins and G proteins in human genetic disease., PMID:39743506
Deciphering the genetic interplay between depression and dysmenorrhea: a Mendelian randomization study., PMID:39592111
A cross-tissue transcriptome-wide association study reveals GRK4 as a novel susceptibility gene for COPD., PMID:39558015
G protein-coupled receptor kinases in hypertension: physiology, pathogenesis, and therapeutic targets., PMID:38961282
Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy., PMID:38951961
Dissecting the shared genetic architecture between Alzheimer's disease and frailty: a cross-trait meta-analyses of genome-wide association studies., PMID:38706793
Quantitative proteomics assay reveals G protein-coupled receptor kinase 4-induced HepG2 cell growth inhibition., PMID:38638965
Chronic exercise improves renal AT1 and ETB receptor functions via modulating GRK4 expression in obese Zucker rats., PMID:38471134
Exosomal miR-122-3p represses the growth and metastasis of MCF-7/ADR cells by targeting GRK4-mediated activation of the Wnt/β-catenin pathway., PMID:38365112
Caveolin-1, a Determinant of the Fate of MCF-7 Breast Cancer Cells., PMID:38298330
Effect of GRK4 on renal gastrin receptor regulation in hypertension., PMID:37641972
Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression., PMID:37622333
Implications of In Vitro Multi-Serine Phosphorylation of Alpha-Synuclein in Aggregation and Cytotoxicity., PMID:37562012
Dopamine Receptor D1R and D3R and GRK4 Interaction in Hypertension., PMID:37009199
Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs., PMID:36878964
Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development., PMID:36810260
Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury., PMID:36669643
LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis., PMID:36552750
Genome-wide identification of SNPs associated with body weight in yak., PMID:36522700
G Protein-Coupled Receptor Kinase 4 Is a Novel Prognostic Factor in Hepatocellular Carcinoma., PMID:35769816
G-protein-coupled receptor kinase 4 causes renal angiotensin II type 2 receptor dysfunction by increasing its phosphorylation., PMID:35695067
Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption., PMID:35661789
Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics., PMID:35487286
GRK4, A Potential Link between Hypertension and Breast Cancer., PMID:37994311
Paternal long-term PM2.5 exposure causes hypertension via increased renal AT1R expression and function in male offspring., PMID:34779863
Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang., PMID:34297769
A narrative review on the interaction between genes and the treatment of hypertension and breast cancer., PMID:34164528
The Hypertension Related Gene G-Protein Coupled Receptor Kinase 4 Contributes to Breast Cancer Proliferation., PMID:34103922
Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma., PMID:33971243
Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients., PMID:33899625
Genetic risk score constructed from common genetic variants is associated with cardiovascular disease risk in type 2 diabetes mellitus., PMID:33350037
The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction., PMID:33280021
Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population., PMID:33127268
GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension., PMID:32940654
Role of GRK4 in the regulation of the renal ETB receptor in hypertension., PMID:32687659
Genetically, Dietary Sodium Intake Is Causally Associated with Salt-Sensitive Hypertension Risk in a Community-Based Cohort Study: a Mendelian Randomization Approach., PMID:32591971
Normal Ethanol Sensitivity and Rapid Tolerance Require the G Protein Receptor Kinase 2 in Ellipsoid Body Neurons in Drosophila., PMID:32573992
ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins., PMID:32391018
Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension., PMID:32349533
Sorting nexin 1 loss results in increased oxidative stress and hypertension., PMID:32293069
Elimination of HER3-expressing breast cancer cells using aptamer-siRNA chimeras., PMID:31555351
Proteomics analysis of G protein-coupled receptor kinase 4-inhibited cellular growth of HEK293 cells., PMID:31349021
[Impact of oxidative stress on renal dopamine D(1) receptor dysfunction in offspring of diabetic rat dams]., PMID:31142084
Specific miRNA-G Protein-Coupled Receptor Networks Regulate Sox9a/Sox9b Activities to Promote Gonadal Rejuvenation in Zebrafish., PMID:31116894
For research use only. Not for human or drug use.
