Catalog No.
YHD95801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys280-Thr532
Predicted molecular weight
30.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P31513
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dimethylaniline oxidase 3, FMO form 2, Dimethylaniline monooxygenase [N-oxide-forming] 3, FMO3, FMO II, FMO 3, Trimethylamine monooxygenase, Hepatic flavin-containing monooxygenase 3
Dietary choline deficiency potentiates Helicobacter pylori-driven gut-liver dysfunction via microbial metabolic rewiring., PMID:40505229
Trimethylamine N-Oxide (TMAO) Acts as Inhibitor of Endothelial Nitric Oxide Synthase (eNOS) and Hampers NO Production and Acetylcholine-Mediated Vasorelaxation in Rat Aortas., PMID:40427399
Negative Impact of Caloric Restriction on Atherosclerosis in Young ApoE/LDLr -/- Mice., PMID:40384342
FMO3 exacerbates hepatic endoplasmic reticulum stress in drug-induced liver injury by inhibiting CREB3/P4HB axis and activating TMAO-mediated PERK pathway., PMID:40345485
FMO2+ cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma., PMID:40316306
IL-6 Affects Liver Metabolic Abnormalities Caused by Silicon Exposure by Regulating the PKC/YY1 Signaling Pathway., PMID:40282416
Buyang Huanwu Decoction stabilizes atherosclerotic vulnerable plaques by regulating intestinal flora, TLR4-NF-κB-NLRP3 inflammatory pathway and mitophagy., PMID:40252436
Unpleasant Smell: A Case Report of Trimethylaminuria (Fish Odour Syndrome) in a Child., PMID:40125190
CELF1 Promotes Post-myocardial Infarction Cardiac Remodeling Via Suppression of FMO2., PMID:40021568
Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver., PMID:39997363
fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans., PMID:39951337
Sulfur Dioxide Alleviates Aortic Dissection Through Inhibiting Vascular Smooth Muscle Cell Phenotype Switch, Migration, and Proliferation via miR-184-3p/Cyp26b1 Axis., PMID:39834177
TMAO is involved in sleep deprivation-induced cognitive dysfunction through regulating astrocytic cholesterol metabolism via SREBP2., PMID:39669439
Transcriptional analysis of C. elegans fmos at different life stages and their roles in ageing., PMID:39636438
Fecal microbiota transplantation validates the importance of gut microbiota in an ApoE-/- mouse model of chronic apical periodontitis-induced atherosclerosis., PMID:39614243
Flavin-Dependent Monooxgenase Confers Resistance to Chlorantraniliprole and Spinetoram in the Rice Stem Borer Chilo suppressalis Walker (Lepidoptera: Crambidae)., PMID:39561259
Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models through its disulfide bond catalytic activity., PMID:39480513
Production of bio-indigo from engineered Pseudomonas putida KT2440 harboring tryptophanase and flavin-containing monooxygenase., PMID:39447513
Bie Jia Jian pill ameliorates BDL-induced cholestatic hepatic fibrosis in rats by regulating intestinal microbial composition and TMAO-mediated PI3K/AKT signaling pathway., PMID:39369915
CYP P450 and non-CYP P450 Drug Metabolizing Enzyme Families Exhibit Differential Sensitivities towards Proinflammatory Cytokine Modulation., PMID:39349298
Structural and Functional Characterization of a Novel Class A Flavin Monooxygenase from Bacillus niacini., PMID:39265075
Semi-rational design based on the interaction between SmFMO and FAD isoalloxazine ring to enhance the enzyme activity., PMID:39197199
Deficiency of flavin-containing monooxygenase 3 protects kidney function after ischemia-reperfusion in mice., PMID:39191965
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE-/- mice via MBOAT2-mediated endoplasmic reticulum stress., PMID:39179098
Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats., PMID:39143579
Asymmetric Sulfoxidations Catalyzed by Bacterial Flavin-Containing Monooxygenases., PMID:39124879
Effects of alcohol consumption and tobacco smoking on the composition of the ensemble of drug metabolizing enzymes and transporters in human liver., PMID:38798409
Fmo induction as a tool to screen for pro-longevity drugs., PMID:38787463
Identification of YUC genes associated with leaf wrinkling trait in Tacai variety of Chinese cabbage., PMID:38784401
Mechanism of Nitrone Formation by a Flavin-Dependent Monooxygenase., PMID:38779817
Quinuclidine N-Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs., PMID:38769015
Flavin-containing monooxygenase (FMO): Beyond xenobiotics., PMID:38713170
Hif-1α expression targets the TMA/Fmo3/TMAO axis to participate in gallbladder cholesterol stone formation in individuals living in plateau regions., PMID:38657913
Impact of CYP2C19, CYP2C9, CYP3A4, and FMO3 Genetic Polymorphisms and Sex on the Pharmacokinetics of Voriconazole after Single and Multiple Doses in Healthy Chinese Subjects., PMID:38654529
Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic., PMID:38622667
Flavin-containing monooxygenases FMOGS-OXs integrate flowering transition and salt tolerance in Arabidopsis thaliana., PMID:38606719
Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes., PMID:38520539
A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models., PMID:38490520
Development of the ARDS-derived gene panel for lung adenocarcinoma prognosis stratification and experiment validation of CCL20 expression., PMID:38356310
Deciphering the diurnal rhythm regulating mechanism of flavin-containing monooxygenase 3 in mouse liver., PMID:38320728
Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources., PMID:38280279
Mice, rats, and guinea pigs differ in FMOs expression and tissue concentration of TMAO, a gut bacteria-derived biomarker of cardiovascular and metabolic diseases., PMID:38266015
Molecular and functional characterization of flavin-containing monooxygenases (FMO1-6) in tree shrews., PMID:38215804
Tryptophan-Based Hyperproduction of Bioindigo by Combinatorial Overexpression of Two Different Tryptophan Transporters., PMID:38213292
A computational insight on the aromatic amino acids conjugation with [Cp*Rh(H2O)3]2+ by using the meta-dynamics/FMO3 approach., PMID:38082186
The therapeutic effect of wine-processed Corni Fructus on chronic renal failure in rats through the interference with the LPS/IL-1-mediated inhibition of RXR function., PMID:38036016
Discovery and identification of the prognostic significance and potential mechanism of FMO2 in breast cancer., PMID:37963835
FMO2 ameliorates nonalcoholic fatty liver disease by suppressing ER-to-Golgi transport of SREBP1., PMID:37874228
Circ_MACF1 targets miR-421 to upregulate FMO2 to suppress paclitaxel resistance and malignant cellular behaviors in lung adenocarcinoma., PMID:37814902
Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation., PMID:37800598
For research use only. Not for human or drug use.
