Catalog No.
YHD93201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu176-Tyr395
Predicted molecular weight
26.86 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P31153
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Methionine adenosyltransferase II, S-adenosylmethionine synthase isoform type-2, MAT 2, AMS2, MAT-II, MATA2, MAT2A, AdoMet synthase 2, Methionine adenosyltransferase 2
Discovery of Potential Scaffolds for Methionine Adenosyltransferase 2A (MAT2A) Inhibitors: Virtual Screening, Synthesis, and Biological Evaluation., PMID:40430308
The complex post-transcriptional regulation of genes coding for methionine adenosyl transferase: New insights for liver cancer., PMID:40348354
Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1-42 in 5 × FAD mice., PMID:40308894
PRPS2 enhances RNA m6A methylation by stimulating SAM synthesis through enzyme-dependent and independent mechanisms., PMID:40295500
Specificity protein 1 (SP1) plays an essential role in early bovine embryo development., PMID:40286422
Methionine cycle inhibition disrupts antioxidant metabolism and reduces glioblastoma cell survival., PMID:40015640
MAT2A Knockdown Enhances Recombinant Protein Expression in Transgenic CHO Cells Through Regulation of Cell Cycle., PMID:40011400
Quercetin Inhibits Ectopic Lesion Formation in Mice by Modulating the MAT2A/PRMT5 Pathway through PPARγ Activation., PMID:39995138
Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma., PMID:39983717
Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets., PMID:39855192
Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models., PMID:39835703
Bacterial indole-3-propionic acid inhibits macrophage IL-1β production through targeting methionine metabolism., PMID:39825207
Advances in Novel Targeted Therapies for Pancreatic Adenocarcinoma., PMID:39762686
MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial., PMID:39762248
Discovery of 2(1H)-Quinoxalinone Derivatives as Potent and Selective MAT2A Inhibitors for the Treatment of MTAP-Deficient Cancers., PMID:39760448
SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication., PMID:39745173
Reciprocal links between methionine metabolism, DNA repair and therapy resistance in glioblastoma., PMID:39651281
Enhancing Radiofrequency Ablation for Hepatocellular Carcinoma: Nano-Epidrug Effects on Immune Modulation and Antigenicity Restoration., PMID:39548919
RBM15-mediated the m6A modification of MAT2A promotes osteosarcoma cell proliferation, metastasis and suppresses ferroptosis., PMID:39527319
MAT2B regulates the protein level of MAT2A to preserve RNA N6-methyladenosine., PMID:39353892
Inhibition of MAT2A Impairs Skeletal Muscle Repair Function., PMID:39334864
The role of forkhead box M1-methionine adenosyltransferase 2 A/2B axis in liver inflammation and fibrosis., PMID:39333125
Modulation of m6A RNA modification by DAP3 in cancer cells., PMID:39316047
SCR-7952, a highly selective MAT2A inhibitor, demonstrates synergistic antitumor activities in combination with the S-adenosylmethionine-competitive or the methylthioadenosine-cooperative protein arginine methyltransferase 5 inhibitors in methylthioadenosine phosphorylase-deleted tumors., PMID:39309689
MAT2A inhibition combats metabolic and transcriptional reprogramming in cancer., PMID:39306235
MAT2A is essential for zygotic genome activation by maintaining of histone methylation in porcine embryos., PMID:39276507
TRIM25 activates Wnt/β-catenin signalling by destabilising MAT2A mRNA to drive thoracic aortic aneurysm development., PMID:39216871
Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer., PMID:39107274
Engineered Methionine Adenosyltransferase Cascades for Metabolic Labeling of Individual DNA Methylomes in Live Cells., PMID:38943667
Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy., PMID:38818879
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition., PMID:38755480
The combination of methionine adenosyltransferase 2A inhibitor and methyltransferase like 3 inhibitor promotes apoptosis of non-small cell lung cancer cells and produces synergistic anti-tumor activity., PMID:38704890
8-Cl-Ado and 8-NH2-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia., PMID:38643304
S-Adenosyl-l-methionine restores brain mitochondrial membrane fluidity and GSH content improving Niemann-Pick type C disease., PMID:38599016
Development of a Series of Pyrrolopyridone MAT2A Inhibitors., PMID:38466661
Quiescence enables unrestricted cell fate in naive embryonic stem cells., PMID:38409226
Discovery of novel MAT2A inhibitors by an allosteric site-compatible fragment growing approach., PMID:38342078
Methylthioadenosine Phosphorylase Genomic Loss in Advanced Gastrointestinal Cancers., PMID:38330461
Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer., PMID:38168934
Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole-Electron Analysis., PMID:38166392
Positive Regulation of S-Adenosylmethionine on Chondrocytic Differentiation via Stimulation of Polyamine Production and the Gene Expression of Chondrogenic Differentiation Factors., PMID:38139122
Knockdown of TPI in human dermal microvascular endothelial cells and its impact on angiogenesis in vitro., PMID:38117832
The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback., PMID:38037054
Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition., PMID:38000655
The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality., PMID:37795443
Characterization of methionine dependence in melanoma cells., PMID:37782107
METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle., PMID:37673880
Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening., PMID:37591318
Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment., PMID:37582769
Functional analysis of 3'-UTR hairpins supports a two-tiered model for posttranscriptional regulation of MAT2A by METTL16., PMID:37567786
For research use only. Not for human or drug use.
