Catalog No.
YHD85801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Val359
Predicted molecular weight
44.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P29992
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
G-protein subunit alpha-11, Guanine nucleotide-binding protein G(y) subunit alpha, GNA11, G alpha-11, GA11, Guanine nucleotide-binding protein subunit alpha-11
Iris and anterior chamber angle melanoma masquerading as benign melanocytic lesion., PMID:40491523
Presence of tumor DNA in aqueous humor is correlated with high risk uveal melanoma., PMID:40461505
Case report: Clinical and genetic characteristics of heterozygous CaSR variants in three Chinese females with familial hypocalciuric hypercalcemia type 1: a report of three cases., PMID:40417236
Short Report: The Variants in CHEK2 in Metastatic Uveal Melanoma., PMID:40283643
Co-occurrence of EIF1AX, SF3B1, or BAP1 variants in uveal melanomas: A case series and review., PMID:40271082
Segmental Congenital Vascular Anomaly With Atrophy, Ulceration and Scarring With Complications in Pregnancy., PMID:40019051
A novel FTO-targeting nanodrug induces disulfidptosis and ameliorates the suppressive tumor immune environment to treat uveal melanoma., PMID:40015005
Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer., PMID:39995872
Gαq/11 aggravates acute lung injury in mice by promoting endoplasmic reticulum stress-mediated NETosis., PMID:39972252
[Research progress of GNAQ/GNA11-related capillary malformation spectrum]., PMID:39938999
Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma., PMID:39838458
An activating calcium-sensing receptor variant with biased signaling reveals a critical residue for Gα11 coupling., PMID:39658204
Phenotypic Spectrum of GNA11 R183C Mosaicism., PMID:39654261
Treatment sequence with tebentafusp and immune checkpoint inhibitors in patients with metastatic uveal melanoma and metastatic GNA11/GNAQ mutant melanocytic tumors., PMID:39647344
Gq/G11 oncogenic mutations promote PD-L1 expression and suppress tumor immunity., PMID:39550833
CYSLTR1 antagonism displays potent anti-tumor effects in uveal melanoma., PMID:39389443
Persistent Thrombotic Hemangioma With Organizing/Anastomosing Features: A Case Report of a Guanine Nucleotide-Binding Protein Alpha Subunit (GNA)-Mutated Cutaneous Vascular Lesion., PMID:39360118
[Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches]., PMID:39355878
Pathogenic Germline Variants in Uveal Melanoma Driver and BAP1-Associated Genes in Finnish Patients with Uveal Melanoma., PMID:39344744
Malignant blue melanoma., PMID:39260463
Genomic landscape of cutaneous, acral, mucosal, and uveal melanoma in Japan: analysis of clinical comprehensive genomic profiling data., PMID:39249554
[Familial Hypocalciuric Hypercalcemia Type 1 Likely Secondary to a New Inactivating Mutation of CASR]., PMID:39243411
NRASQ61R-driven atypical melanocytic tumor with blue nevus-like morphology: A case report., PMID:39177027
Familial hypocalciuric hypercalcemia in an infant: diagnosis and management quandaries., PMID:39163488
Protein and mRNA Expression in Uveal Melanoma Cell Lines Are Related to GNA and BAP1 Mutation Status., PMID:39042403
RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss., PMID:39009565
Delineation of the phenotypes and genotypes of PIK3CA-related overgrowth spectrum in East asians., PMID:38980418
Loss-of-function Thr347Ala Variant in the G Protein Subunit-Α11 Causes Familial Hypocalciuric Hypercalcemia 2., PMID:38920275
Somatic GNA11/GNAQ variants in a cohort of Chinese children with phakomatosis pigmentovascularis., PMID:38910853
Clinical and genetic characteristics of BAP1-mutated non-uveal and uveal melanoma., PMID:38903495
Molecularly matched targeted therapy: a promising approach for refractory metastatic melanoma., PMID:38761384
Utility of next-generation sequencing in the diagnosis of metastatic melanoma: A case report., PMID:38757469
[Circumscribed choroidal hemangioma and non-pigmented choroidal melanoma: clinical, instrumental and molecular genetic features]., PMID:38742493
A Phase II Study of ERK Inhibition by Ulixertinib (BVD-523) in Metastatic Uveal Melanoma., PMID:38683104
Identification and validation of a costimulatory molecule-related signature to predict the prognosis for uveal melanoma patients., PMID:38644411
Gα11 deficiency increases fibroblast growth factor 23 levels in a mouse model of familial hypocalciuric hypercalcemia., PMID:38530370
Double somatic mutations in CTNNB1 and GNA11 in an aldosterone-producing adenoma., PMID:38505749
Identification and characterization of a novel CASR mutation causing familial hypocalciuric hypercalcemia., PMID:38487341
EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway., PMID:38486999
Molecular Frontiers in Melanoma: Pathogenesis, Diagnosis, and Therapeutic Advances., PMID:38474231
Somatic Loss-of-Function PIK3R1 and Activating Non-hotspot PIK3CA Mutations Associated with Capillary Malformation with Dilated Veins (CMDV)., PMID:38431221
PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma., PMID:38418838
Emerging therapeutic strategies for metastatic uveal melanoma: Targeting driver mutations., PMID:38411373
Mass Spectrometry-Based Profiling of Histone Post-Translational Modifications in Uveal Melanoma Tissues, Human Melanocytes, and Uveal Melanoma Cell Lines - A Pilot Study., PMID:38349785
Epilepsy with faint capillary malformation or reticulated telangiectasia associated with mosaic AKT3 pathogenic variants., PMID:38321651
Clinical and Genomic Predictors of Adverse Events in Newly Diagnosed Glioblastoma., PMID:38252427
Cooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodia., PMID:38233537
INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas., PMID:38233483
Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma., PMID:38198520
For research use only. Not for human or drug use.
