Catalog No.
YHD82801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe244-Phe515
Predicted molecular weight
33.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P29350
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HCP, PTPN6, PTP1C, Hematopoietic cell protein-tyrosine phosphatase, SH-PTP1, Protein-tyrosine phosphatase SHP-1, Protein-tyrosine phosphatase 1C, Tyrosine-protein phosphatase non-receptor type 6, PTP-1C
Macrophage histone lactylation in atherosclerosis progression: mechanisms, predictive models, and therapeutic potential of Ruan Jian Qing Mai formula., PMID:40449878
The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets., PMID:40446800
Phosphorylation of ITIM motifs drives the structural transition of indoleamine 2,3-dioxygenase 1 between enzymatic and non-enzymatic states., PMID:40371730
Effects of Asiatic acid on brain cancer by altering astrocytes and the AKT1-PRKCB signaling pathway: A genomic and network pharmacology perspective., PMID:40252893
Shp-1 regulates the activity of low-affinity T cells specific to endogenous self-antigen during melanoma tumor growth and drives resistance to immune checkpoint inhibition., PMID:40246583
Decoding the selective mechanism behind a monobody inhibitor to the phosphatase domain of SHP2: insights from molecular dynamics simulations., PMID:40230273
Novel small non-coding RNAs of Epstein-Barr virus upregulated upon lytic reactivation aid in viral genomic replication and virion production., PMID:40197026
Multi-omic analyses reveal PTPN6's impact on tumor immunity across various cancers., PMID:40164665
SIRPα modulates microglial efferocytosis and neuroinflammation following experimental subarachnoid hemorrhage via the SHP1/STAT6 axis., PMID:40108663
AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity., PMID:40106436
Endothelial SHP-1 regulates diabetes-induced abnormal collateral vessel formation and endothelial cell senescence., PMID:40068773
Analysis of cellular senescence-related genes in calcified aortic valve disease and the potential therapeutic role of β-Carotene., PMID:40063555
E2F2 induces microglial activation and augments depressive-like behavior in mice by repressing PTPN6 transcription., PMID:39991704
Development of coumarin and procaine linked hybrid molecules as a novel class of SHP1 fluorescent activators., PMID:39987836
PerC B-Cells Activation via Thermogenetics-Based CXCL12 Generator for Intraperitoneal Immunity Against Metastatic Disseminated Tumor Cells., PMID:39865939
TREM2 alleviates sepsis-induced acute lung injury by attenuating ferroptosis via the SHP1/STAT3 pathway., PMID:39814108
T Lymphocyte-Specific Deletion of SHP1 and SHP2 Promotes Activation-Induced Cell Death of CD4+ T Cells and Impairs Antitumor Response., PMID:39803505
Mechanism of Ligusticum wallichii-Borneol in the Treatment of Cerebral Ischemic Stroke in Rats Based On Network Pharmacology, Molecular Docking, and Experimental Verification., PMID:39714965
Targeting protein tyrosine phosphatase non-receptor type 6 (PTPN6) as a therapeutic strategy in acute myeloid leukemia., PMID:39707066
Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa., PMID:39682729
Balancing immune response: SHP1 controls neutrophil activation in inflamed lungs., PMID:39680457
TMP: A dual modulator of apoptosis and autophagy via SHP-1 regulation in hepatocellular carcinoma., PMID:39675549
The novel role of LOC344887 in the enhancement of hepatocellular carcinoma progression via modulation of SHP1-regulated STAT3/HMGA2 signaling axis., PMID:39664573
Isobavachin attenuates FcεRI-mediated inflammatory allergic responses by regulating SHP-1-dependent Fyn/Lyn/Syk/Lck signaling., PMID:39643121
Overexpression of Glycosyltransferase 8 Domain Containing 1 Promotes Gastric Cancer Proliferation and Inhibits Apoptosis via Mediating PTPN6/JAK2/STAT3 Signaling Axis., PMID:39628694
Effects of PTPN6 Gene Knockdown in SKM-1 Cells on Apoptosis, Erythroid Differentiation and Inflammations., PMID:39590309
ZNF350 gene polymorphisms promote the response to Peg-IFNα therapy through JAK-STAT signaling pathway in patients with chronic hepatitis B., PMID:39575240
Enhanced Tumor Immunotherapy by Triple Amplification Effects of Nanomedicine on the STING Signaling Pathway in Dendritic Cells., PMID:39440648
Construction and multiple validations of a robust ferroptosis-related prognostic model in bladder cancer: A comprehensive study., PMID:39432593
SHP-1 alleviates acute liver injury caused by Escherichia coli sepsis through negatively regulating the canonical and non-canonical NFκB signaling pathways., PMID:39413645
TREM2 aggravates sepsis by inhibiting fatty acid oxidation via the SHP1/BTK axis., PMID:39405126
Pan-cancer analysis of the prognostic and immunological roles of SHP-1/ptpn6., PMID:39367146
Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury., PMID:39352872
CD33 and SHP-1/PTPN6 Interaction in Alzheimer's Disease., PMID:39336795
DJ-1 regulates astrocyte activation through miR-155/SHP-1 signaling in cerebral ischemia/reperfusion injury., PMID:39323054
Identification and experimental validation of genes associated with programmed cell death in dendritic cells of the thyroid tissue in Hashimoto's thyroiditis., PMID:39260305
Inflammatory disease status and response to TNF blockade are associated with mechanisms of endotoxin tolerance., PMID:39116634
The Role of Cyclin d1 in Radiotherapy Resistance of Advance Stage Nasopharyngeal Carcinoma: A Systematic Review., PMID:39068551
Mechanistic study of inhibitory peptides with SHP-1 in hypertonic environment for infection model., PMID:38996989
A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification., PMID:38992170
Synthesis, Fluorescence, and Bioactivity of Novel Isatin Derivatives., PMID:38875519
Regulation of PPARγ2 Stability and Activity by SHP-1., PMID:38828991
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression., PMID:38752471
Human T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation., PMID:38734673
Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP-1 expression, and the STAT3 pathway., PMID:38708996
A novel diagnostic model based on lncRNA PTPRE expression, neutrophil count and red blood cell distribution width for diagnosis of seronegative rheumatoid arthritis., PMID:38662200
Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders., PMID:38649851
Mechanism study of tyrosine phosphatase shp-1 in inhibiting hepatocellular carcinoma progression by regulating the SHP2/GM-CSF pathway in TAMs., PMID:38644382
Construction and experimental validation of a novel ferroptosis-related gene signature for myelodysplastic syndromes., PMID:38578040
5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells., PMID:38534772
For research use only. Not for human or drug use.
