Catalog No.
YHD81701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala500-Asn753
Predicted molecular weight
31.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P29120
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PC1, PCSK1, Neuroendocrine convertase 1, Prohormone convertase 1, Proprotein convertase 1, NEC 1, NEC1
(-)-Oleuropein as a Novel Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence Suppressor via Targeting PCSK9-LDLR Axis., PMID:40362754
A transcriptomic and proteomic analysis and comparison of human brain tissue from patients with and without epilepsy., PMID:40350490
Modeling diabetic alpha cell dysfunction using stem cell-derived alpha cells., PMID:40345205
The Interplay of UCP3 and PCSK1 Variants in Severe Obesity., PMID:40281302
Early childhood height, weight, and BMI development in children with monogenic obesity: a European multicentre, retrospective, observational study., PMID:40246357
Modulation of satiety hormones by Bacteroides thetaiotaomicron, Bacteroides fragilis and their derivatives., PMID:40044987
Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide., PMID:40044869
Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning., PMID:39948378
A comprehensive spatio-cellular map of the human hypothalamus., PMID:39910307
Pathogenic Deep Intronic PCSK1 Variant Causes Proprotein Convertase 1/3 Deficiency in a Family., PMID:39891480
Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation., PMID:39607428
Bioinformatical analysis and experimental validation of endoplasmic reticulum stress-related biomarker genes in type 2 diabetes mellitus., PMID:39553470
Setmelanotide in patients aged 2-5 years with rare MC4R pathway-associated obesity (VENTURE): a 1 year, open-label, multicenter, phase 3 trial., PMID:39549719
Cystic fibrosis-related diabetes is associated with reduced islet protein expression of GLP-1 receptor and perturbation of cell-specific transcriptional programs., PMID:39463434
Fam3a-mediated prohormone convertase switch in α-cells regulates pancreatic GLP-1 production in an Nr4a2-Foxa2-dependent manner., PMID:39362520
Pea protein hydrolysate stimulates GLP-1 secretion in NCI-H716 cells via simultaneously activating the sensing receptors CaSR and PepT1., PMID:39302035
PCSK1N as a Tumor Size Marker and an ER Stress Response Protein in Corticotroph Pituitary Adenomas., PMID:39288010
Identification of novel drug targets for osteoarthritis by integrating genetics and proteomes from blood., PMID:39261869
Identification and functional validation of rare coding variants in genes linked to monogenic obesity., PMID:39192769
Genetics of glucose homeostasis in pregnancy and postpartum., PMID:39180581
Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage., PMID:39122737
New labdane diterpenoids from Alpinia galanga: A new type of GLP-1 secretagogues targeting the PKA-CREB and PI3K-Akt signaling axes., PMID:39031533
Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer's disease., PMID:38987357
Data-independent acquisition combined with liquid chromatography mass spectrometry technique to detect prognostic protein markers in type I gastric neuroendocrine neoplasm., PMID:38887896
Prognostic implications of STK11 with different mutation status and its relationship with tumor-infiltrating immune cells in non-small cell lung cancer., PMID:38736875
Heterologous expression of P9 from Akkermansia muciniphila increases the GLP-1 secretion of intestinal L cells., PMID:38727988
Unraveling the significance of PPP1R1A gene in pancreatic β-cell function: A study in INS-1 cells and human pancreatic islets., PMID:38574885
Gut Microbiota-Tryptophan Metabolism-GLP-1 Axis Participates in β-Cell Regeneration Induced by Dapagliflozin., PMID:38471012
Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant., PMID:38469147
Suppressive action of nesfatin-1 and nesfatin-1-like peptide on cortisol synthesis in human adrenal cortex cells., PMID:38368491
Could setmelanotide be the game-changer for acquired hypothalamic obesity?, PMID:38239988
Peak-agnostic high-resolution cis-regulatory circuitry mapping using single cell multiome data., PMID:38084892
Differential sex-association between PCSK1 polymorphisms and obesity risk in Portuguese children., PMID:38009939
Management of Monogenic and Syndromic Obesity., PMID:37919024
The N221D variant in PCSK1 is highly prevalent in childhood obesity and can influence the metabolic profile., PMID:37877373
Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations., PMID:37787501
Association of PCSK1 and PPARG1 Allelic Variants with Obesity and Metabolic Syndrome in Mexican Adults., PMID:37761915
Identification of genes related to glucose metabolism and analysis of the immune characteristics in Alzheimer's disease., PMID:37619853
Calnuc-derived nesfatin-1-like peptide is an activator of tumor cell proliferation and migration., PMID:37539786
Tissue-Specific Modulation of Gluco- and Growth-Regulatory Factor Abundance by Nesfatin-1 and Nesfatin-1-like Peptide in Goldfish., PMID:37174474
Identification and Characteristics of Novel Mutations in Nonsyndromic Monogenic Obesity., PMID:37083215
In vitro comparison of whey protein isolate and hydrolysate for their effect on glucose homeostasis markers., PMID:37066543
Birth weight concerning obesity and diabetes gene expression in healthy infants; a case-control study., PMID:36997916
Functional differentiation of the ovine preadipocytes -insights from gene expression profiling., PMID:36952056
Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants., PMID:36864747
Contribution of heterozygous PCSK1 variants to obesity and implications for precision medicine: a case-control study., PMID:36822744
Next-generation sequencing of 12 obesity genes in a Portuguese cohort of patients with overweight and obesity., PMID:36775011
Setmelanotide: a promising advancement for pediatric patients with rare forms of genetic obesity., PMID:36722447
A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing., PMID:36694809
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis., PMID:36543979
For research use only. Not for human or drug use.
